Incidental Mutation 'R3932:Odc1'
ID 308519
Institutional Source Beutler Lab
Gene Symbol Odc1
Ensembl Gene ENSMUSG00000011179
Gene Name ornithine decarboxylase, structural 1
Synonyms ODC
MMRRC Submission 040919-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3932 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 17594906-17601503 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 17598801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 227 (F227Y)
Ref Sequence ENSEMBL: ENSMUSP00000128661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171737] [ENSMUST00000222617]
AlphaFold P00860
PDB Structure CRYSTAL STRUCTURE ORNITHINE DECARBOXYLASE FROM MOUSE, TRUNCATED 37 RESIDUES FROM THE C-TERMINUS, TO 1.6 ANGSTROM RESOLUTION [X-RAY DIFFRACTION]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082493
Predicted Effect probably benign
Transcript: ENSMUST00000171737
AA Change: F227Y

PolyPhen 2 Score 0.375 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000128661
Gene: ENSMUSG00000011179
AA Change: F227Y

DomainStartEndE-ValueType
Pfam:Orn_Arg_deC_N 44 282 2.2e-93 PFAM
Pfam:Orn_DAP_Arg_deC 286 407 1.7e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220849
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220947
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221354
Predicted Effect probably benign
Transcript: ENSMUST00000221613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221701
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222250
Predicted Effect probably benign
Transcript: ENSMUST00000222617
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222758
Meta Mutation Damage Score 0.0744 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.1%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
PHENOTYPE: Homozygous null embryos die prior to gastrulation. [provided by MGI curators]
Allele List at MGI

All alleles(9) : Targeted, other(3) Gene trapped(6)  

Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap3b2 C T 7: 81,123,598 (GRCm39) probably benign Het
Arl1 C T 10: 88,569,398 (GRCm39) probably benign Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp10a T C 7: 58,476,852 (GRCm39) M1189T possibly damaging Het
Bcl2l14 A G 6: 134,400,771 (GRCm39) D64G probably damaging Het
Cdc34b G A 11: 94,633,441 (GRCm39) V214M probably benign Het
Cfap54 T C 10: 92,665,619 (GRCm39) T2985A probably benign Het
Clcc1 T C 3: 108,580,682 (GRCm39) M332T probably damaging Het
Coch T C 12: 51,650,121 (GRCm39) I370T probably damaging Het
Ctdnep1 A G 11: 69,880,400 (GRCm39) probably benign Het
Edar C T 10: 58,446,164 (GRCm39) C221Y probably damaging Het
Fam135b T A 15: 71,322,280 (GRCm39) Q1295L probably benign Het
Fam184a C T 10: 53,575,397 (GRCm39) A71T probably damaging Het
Fbxw10 A G 11: 62,759,983 (GRCm39) probably benign Het
Frmd4a T C 2: 4,542,071 (GRCm39) W247R probably damaging Het
Gcn1 A G 5: 115,725,893 (GRCm39) H553R probably benign Het
Grin3a C T 4: 49,672,472 (GRCm39) probably null Het
H2-Q6 C T 17: 35,644,542 (GRCm39) probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hspg2 T C 4: 137,242,879 (GRCm39) V670A probably damaging Het
Med10 A G 13: 69,958,101 (GRCm39) N18D probably damaging Het
Mgat4b T A 11: 50,124,165 (GRCm39) H368Q possibly damaging Het
Morn5 C A 2: 35,943,035 (GRCm39) T45N probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Msl3 C T X: 167,454,813 (GRCm39) A87T probably damaging Het
Myrf T C 19: 10,195,515 (GRCm39) T432A probably damaging Het
Nalf2 G A X: 98,865,470 (GRCm39) V266M possibly damaging Het
Nav3 T A 10: 109,529,896 (GRCm39) E2148D probably damaging Het
Nfe2l3 A G 6: 51,433,595 (GRCm39) T236A possibly damaging Het
Opa1 A T 16: 29,429,698 (GRCm39) E401D probably damaging Het
Or5b21 T C 19: 12,839,994 (GRCm39) M285T possibly damaging Het
Pdcd1 T C 1: 93,968,989 (GRCm39) I110V probably benign Het
Pde5a G A 3: 122,554,545 (GRCm39) E212K probably damaging Het
Plin4 A G 17: 56,413,704 (GRCm39) I307T probably benign Het
Rag1 T C 2: 101,473,384 (GRCm39) Y586C probably damaging Het
Rgs7bp T C 13: 105,189,506 (GRCm39) M98V probably benign Het
Rgs9 A G 11: 109,166,639 (GRCm39) probably benign Het
Rin3 A G 12: 102,356,342 (GRCm39) D961G probably damaging Het
Rubcn A G 16: 32,649,629 (GRCm39) probably null Het
Slc13a2 T A 11: 78,289,226 (GRCm39) Y495F probably damaging Het
Tfec T A 6: 16,845,458 (GRCm39) D67V probably damaging Het
Tmem94 T C 11: 115,680,080 (GRCm39) M30T probably benign Het
Tsbp1 A G 17: 34,662,417 (GRCm39) T86A possibly damaging Het
Tubgcp6 A G 15: 88,988,617 (GRCm39) probably benign Het
Vmn2r10 C A 5: 109,150,088 (GRCm39) A319S possibly damaging Het
Vmn2r85 T C 10: 130,254,336 (GRCm39) M783V probably damaging Het
Zfp422 T C 6: 116,603,420 (GRCm39) K193R probably benign Het
Zfp94 T G 7: 24,003,112 (GRCm39) D110A probably benign Het
Other mutations in Odc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Odc1 APN 12 17,597,674 (GRCm39) missense probably damaging 1.00
IGL02234:Odc1 APN 12 17,598,621 (GRCm39) missense possibly damaging 0.95
IGL03007:Odc1 APN 12 17,598,811 (GRCm39) missense probably benign 0.01
F5426:Odc1 UTSW 12 17,599,424 (GRCm39) critical splice acceptor site probably null
H8562:Odc1 UTSW 12 17,598,038 (GRCm39) missense probably benign 0.11
R1648:Odc1 UTSW 12 17,598,538 (GRCm39) splice site probably benign
R1898:Odc1 UTSW 12 17,598,842 (GRCm39) missense probably damaging 1.00
R2224:Odc1 UTSW 12 17,597,336 (GRCm39) missense probably benign 0.05
R2274:Odc1 UTSW 12 17,598,425 (GRCm39) missense probably benign 0.01
R4883:Odc1 UTSW 12 17,597,386 (GRCm39) missense possibly damaging 0.82
R4956:Odc1 UTSW 12 17,597,958 (GRCm39) missense probably damaging 1.00
R5036:Odc1 UTSW 12 17,598,020 (GRCm39) missense probably damaging 1.00
R6112:Odc1 UTSW 12 17,599,473 (GRCm39) missense probably benign 0.23
R6261:Odc1 UTSW 12 17,600,655 (GRCm39) missense probably benign 0.00
R7092:Odc1 UTSW 12 17,598,314 (GRCm39) missense possibly damaging 0.90
R7101:Odc1 UTSW 12 17,597,319 (GRCm39) missense probably benign
R7243:Odc1 UTSW 12 17,600,058 (GRCm39) nonsense probably null
R7638:Odc1 UTSW 12 17,600,003 (GRCm39) missense probably damaging 0.99
R8496:Odc1 UTSW 12 17,598,396 (GRCm39) missense probably damaging 1.00
R8924:Odc1 UTSW 12 17,598,329 (GRCm39) missense possibly damaging 0.93
R9218:Odc1 UTSW 12 17,598,312 (GRCm39) nonsense probably null
R9647:Odc1 UTSW 12 17,598,614 (GRCm39) missense possibly damaging 0.93
Z1177:Odc1 UTSW 12 17,600,723 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGACATGGCAGTGAGTACAC -3'
(R):5'- GGCTACCGTACACCAGTCAATG -3'

Sequencing Primer
(F):5'- TACACGGGACTTGTTCAAGG -3'
(R):5'- CCAGTCAATGGGATTGCAGC -3'
Posted On 2015-04-17