Incidental Mutation 'R0379:Cyp4a32'
ID 30853
Institutional Source Beutler Lab
Gene Symbol Cyp4a32
Ensembl Gene ENSMUSG00000063929
Gene Name cytochrome P450, family 4, subfamily a, polypeptide 32
Synonyms OTTMUSG00000008689
MMRRC Submission 038585-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R0379 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 115458166-115478799 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 115478671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 468 (V468M)
Ref Sequence ENSEMBL: ENSMUSP00000081369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084342] [ENSMUST00000102707]
AlphaFold A2A8T1
Predicted Effect probably damaging
Transcript: ENSMUST00000084342
AA Change: V468M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: V468M

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 1.3e-133 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102707
SMART Domains Protein: ENSMUSP00000099768
Gene: ENSMUSG00000028713

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:p450 46 501 1.3e-130 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135569
Predicted Effect probably benign
Transcript: ENSMUST00000145841
SMART Domains Protein: ENSMUSP00000118323
Gene: ENSMUSG00000028713

DomainStartEndE-ValueType
Pfam:p450 1 375 3.5e-101 PFAM
Meta Mutation Damage Score 0.4434 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.9%
Validation Efficiency 98% (79/81)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930512M02Rik A G 11: 11,539,365 (GRCm39) probably benign Het
Apba1 A C 19: 23,912,194 (GRCm39) N558T probably damaging Het
Arfgef2 T A 2: 166,702,320 (GRCm39) probably null Het
Arsb T C 13: 94,077,135 (GRCm39) S501P probably benign Het
Atp10b A G 11: 43,145,141 (GRCm39) T1295A probably benign Het
Atp8b5 G T 4: 43,361,898 (GRCm39) R648L probably damaging Het
Bcl2a1b T C 9: 89,081,789 (GRCm39) I126T possibly damaging Het
Brd9 T C 13: 74,090,802 (GRCm39) probably benign Het
Cd93 T C 2: 148,283,430 (GRCm39) probably benign Het
Chd5 A G 4: 152,467,778 (GRCm39) K1692R probably benign Het
Clcn4 T C 7: 7,299,791 (GRCm39) T13A probably damaging Het
Clec14a A G 12: 58,315,580 (GRCm39) F14S possibly damaging Het
Clec4g A G 8: 3,768,440 (GRCm39) V97A probably benign Het
Col24a1 G A 3: 145,229,897 (GRCm39) R1483K possibly damaging Het
Crem A T 18: 3,299,226 (GRCm39) V82D probably damaging Het
Ctnna2 T A 6: 77,618,423 (GRCm39) T180S probably benign Het
Cybrd1 T C 2: 70,960,099 (GRCm39) I99T probably benign Het
Dlk1 A G 12: 109,420,985 (GRCm39) probably benign Het
Dnaaf9 C T 2: 130,627,466 (GRCm39) probably benign Het
Dnah7b A T 1: 46,179,336 (GRCm39) Y1003F probably benign Het
Egfem1 A C 3: 29,722,399 (GRCm39) E376A possibly damaging Het
Etl4 T A 2: 20,812,165 (GRCm39) I1416K probably damaging Het
Fbxl4 A G 4: 22,386,106 (GRCm39) T238A probably benign Het
Fer1l6 A G 15: 58,420,187 (GRCm39) I33M probably benign Het
Fndc3a A G 14: 72,794,049 (GRCm39) S830P probably damaging Het
Fras1 C T 5: 96,903,368 (GRCm39) R3082* probably null Het
Galnt13 T C 2: 54,950,504 (GRCm39) V395A possibly damaging Het
Gpd2 C T 2: 57,235,275 (GRCm39) T335I probably damaging Het
Gucy2d C A 7: 98,108,209 (GRCm39) probably null Het
Hydin A G 8: 111,235,759 (GRCm39) probably benign Het
Ints5 G T 19: 8,874,497 (GRCm39) V819L possibly damaging Het
Klhdc10 C G 6: 30,450,669 (GRCm39) Q292E possibly damaging Het
Lmbrd2 G A 15: 9,149,566 (GRCm39) A67T probably benign Het
Lrp1 T G 10: 127,430,838 (GRCm39) T404P probably damaging Het
Marchf7 T C 2: 60,064,470 (GRCm39) S249P probably benign Het
Mcm10 T A 2: 5,013,434 (GRCm39) K66M probably benign Het
Mtmr7 C A 8: 41,004,642 (GRCm39) D645Y probably damaging Het
Muc6 T A 7: 141,216,868 (GRCm39) I2602F possibly damaging Het
Myh13 G A 11: 67,260,121 (GRCm39) probably benign Het
Myo18a G A 11: 77,741,632 (GRCm39) V1776I possibly damaging Het
Ncapg2 T C 12: 116,406,695 (GRCm39) L957S probably damaging Het
Ncoa3 T C 2: 165,896,422 (GRCm39) S442P probably damaging Het
Or5t5 G A 2: 86,616,079 (GRCm39) E2K probably benign Het
Or6x1 G A 9: 40,098,729 (GRCm39) G106D probably damaging Het
Or7g32 T A 9: 19,388,776 (GRCm39) T257S possibly damaging Het
Pdcd6 G T 13: 74,457,831 (GRCm39) N113K possibly damaging Het
Pfkfb4 C T 9: 108,856,810 (GRCm39) probably benign Het
Pfkm A G 15: 98,024,195 (GRCm39) H401R probably benign Het
Phldb2 C A 16: 45,601,814 (GRCm39) D754Y probably damaging Het
Plekhb2 T A 1: 34,902,195 (GRCm39) M49K probably damaging Het
Polrmt A G 10: 79,573,445 (GRCm39) S1057P possibly damaging Het
Prps1l1 A G 12: 35,035,077 (GRCm39) N64S probably benign Het
Prss3l T G 6: 41,422,190 (GRCm39) probably benign Het
Psg16 T C 7: 16,864,583 (GRCm39) S393P probably benign Het
Rundc1 C T 11: 101,315,973 (GRCm39) T15I probably benign Het
Scaf11 A G 15: 96,329,697 (GRCm39) L143S probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Serpinf1 T G 11: 75,304,771 (GRCm39) I197L probably benign Het
Siglec1 C T 2: 130,916,445 (GRCm39) probably benign Het
Slc28a1 G A 7: 80,787,925 (GRCm39) V271I probably benign Het
Sntg1 T C 1: 8,853,048 (GRCm39) D34G probably damaging Het
Sptbn4 A T 7: 27,059,161 (GRCm39) probably benign Het
Suclg1 T C 6: 73,233,211 (GRCm39) I51T possibly damaging Het
Syne1 C T 10: 5,491,989 (GRCm39) R9Q probably damaging Het
Trim47 T A 11: 115,997,344 (GRCm39) H470L probably damaging Het
Ttc41 T A 10: 86,548,841 (GRCm39) Y12N possibly damaging Het
Tubgcp2 T C 7: 139,612,105 (GRCm39) E69G probably damaging Het
Tubgcp3 G A 8: 12,691,116 (GRCm39) T474M probably damaging Het
Ubr5 A T 15: 38,019,201 (GRCm39) N777K probably benign Het
Ush2a T C 1: 188,184,016 (GRCm39) L1440P probably damaging Het
Usp28 A C 9: 48,935,367 (GRCm39) D458A possibly damaging Het
Vcan A T 13: 89,851,665 (GRCm39) D1098E probably damaging Het
Vmn1r73 C T 7: 11,490,773 (GRCm39) T197I probably benign Het
Vmn2r15 T C 5: 109,434,344 (GRCm39) S787G probably damaging Het
Vmn2r90 T A 17: 17,948,401 (GRCm39) I549N probably damaging Het
Vps33b T A 7: 79,933,162 (GRCm39) probably null Het
Zfp516 A T 18: 83,005,795 (GRCm39) K900* probably null Het
Zfp974 T A 7: 27,610,357 (GRCm39) N456I probably damaging Het
Other mutations in Cyp4a32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02225:Cyp4a32 APN 4 115,467,700 (GRCm39) missense probably benign
IGL02546:Cyp4a32 APN 4 115,468,520 (GRCm39) missense probably damaging 0.98
IGL02578:Cyp4a32 APN 4 115,466,939 (GRCm39) missense possibly damaging 0.79
IGL02663:Cyp4a32 APN 4 115,467,787 (GRCm39) missense probably damaging 1.00
IGL02832:Cyp4a32 APN 4 115,471,818 (GRCm39) missense probably damaging 0.99
IGL03283:Cyp4a32 APN 4 115,468,280 (GRCm39) missense possibly damaging 0.79
IGL03357:Cyp4a32 APN 4 115,468,798 (GRCm39) missense probably benign 0.00
IGL03406:Cyp4a32 APN 4 115,459,500 (GRCm39) missense probably benign 0.00
R1339:Cyp4a32 UTSW 4 115,468,760 (GRCm39) missense probably damaging 0.98
R1435:Cyp4a32 UTSW 4 115,463,863 (GRCm39) missense probably damaging 0.97
R1445:Cyp4a32 UTSW 4 115,460,147 (GRCm39) nonsense probably null
R1520:Cyp4a32 UTSW 4 115,471,849 (GRCm39) missense probably damaging 0.97
R1587:Cyp4a32 UTSW 4 115,467,731 (GRCm39) missense probably benign 0.06
R1719:Cyp4a32 UTSW 4 115,468,505 (GRCm39) missense possibly damaging 0.61
R1932:Cyp4a32 UTSW 4 115,468,474 (GRCm39) missense possibly damaging 0.78
R4184:Cyp4a32 UTSW 4 115,478,720 (GRCm39) missense possibly damaging 0.94
R4580:Cyp4a32 UTSW 4 115,460,126 (GRCm39) splice site silent
R5004:Cyp4a32 UTSW 4 115,458,238 (GRCm39) missense probably damaging 0.98
R6345:Cyp4a32 UTSW 4 115,459,560 (GRCm39) missense possibly damaging 0.81
R7231:Cyp4a32 UTSW 4 115,466,894 (GRCm39) missense probably damaging 1.00
R7241:Cyp4a32 UTSW 4 115,459,499 (GRCm39) missense probably benign
R7419:Cyp4a32 UTSW 4 115,468,234 (GRCm39) missense probably benign
R7716:Cyp4a32 UTSW 4 115,458,283 (GRCm39) missense probably damaging 1.00
R8921:Cyp4a32 UTSW 4 115,468,460 (GRCm39) missense probably damaging 0.99
R9009:Cyp4a32 UTSW 4 115,467,802 (GRCm39) missense probably null 1.00
R9266:Cyp4a32 UTSW 4 115,468,307 (GRCm39) missense probably damaging 1.00
R9330:Cyp4a32 UTSW 4 115,478,635 (GRCm39) missense probably damaging 1.00
R9345:Cyp4a32 UTSW 4 115,467,699 (GRCm39) missense probably benign
R9442:Cyp4a32 UTSW 4 115,468,422 (GRCm39) missense probably benign 0.21
Z1177:Cyp4a32 UTSW 4 115,468,542 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CTCCCTGAATGGCGTAAACTAAGCA -3'
(R):5'- TCATGGGGAATCTAGAGCAAGGTGT -3'

Sequencing Primer
(F):5'- GTCCTTAAAATACTGGCCTAACAG -3'
(R):5'- agagagagagagagagagagagagag -3'
Posted On 2013-04-24