Incidental Mutation 'R3939:Or13g1'
ID 308602
Institutional Source Beutler Lab
Gene Symbol Or13g1
Ensembl Gene ENSMUSG00000054054
Gene Name olfactory receptor family 13 subfamily G member 1
Synonyms MOR251-4P, GA_x6K02T2NHDJ-9801340-9802266, Olfr309
MMRRC Submission 040826-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R3939 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 85955393-85956319 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85955437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 295 (M295V)
Ref Sequence ENSEMBL: ENSMUSP00000134377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055690] [ENSMUST00000174158]
AlphaFold Q7TS01
Predicted Effect probably benign
Transcript: ENSMUST00000055690
AA Change: M295V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000061929
Gene: ENSMUSG00000054054
AA Change: M295V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 303 4.5e-11 PFAM
Pfam:7tm_1 39 288 1.5e-26 PFAM
Pfam:7tm_4 137 281 7.9e-44 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174158
AA Change: M295V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000134377
Gene: ENSMUSG00000054054
AA Change: M295V

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.6e-55 PFAM
Pfam:7TM_GPCR_Srsx 33 303 4.5e-11 PFAM
Pfam:7tm_1 39 288 2.4e-18 PFAM
Meta Mutation Damage Score 0.1387 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 97% (37/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik C T X: 69,438,135 (GRCm39) A53T probably benign Het
Atp13a2 T C 4: 140,733,733 (GRCm39) S1041P probably damaging Het
Brinp3 C A 1: 146,627,599 (GRCm39) D277E probably damaging Het
Cacnb4 C A 2: 52,359,501 (GRCm39) R169L probably damaging Het
Col13a1 T C 10: 61,698,861 (GRCm39) I491V unknown Het
Corin T C 5: 72,497,222 (GRCm39) D531G possibly damaging Het
Cx3cr1 C T 9: 119,880,710 (GRCm39) V231I probably benign Het
Dennd4c T G 4: 86,692,517 (GRCm39) V9G probably damaging Het
Dysf G A 6: 84,163,491 (GRCm39) probably null Het
Faf1 T G 4: 109,719,076 (GRCm39) L394R probably damaging Het
Fgfr4 G A 13: 55,304,307 (GRCm39) D116N probably null Het
Flt3 A G 5: 147,293,053 (GRCm39) Y518H possibly damaging Het
Frem3 T C 8: 81,341,649 (GRCm39) I1314T possibly damaging Het
Gk2 T A 5: 97,603,211 (GRCm39) L542F possibly damaging Het
Gm4922 T A 10: 18,660,362 (GRCm39) E120V probably damaging Het
Hip1 A T 5: 135,457,618 (GRCm39) I285N probably benign Het
Kcnd2 C A 6: 21,217,095 (GRCm39) D266E probably damaging Het
Kdr C T 5: 76,133,089 (GRCm39) W63* probably null Het
Kit A G 5: 75,769,978 (GRCm39) D130G probably benign Het
Megf8 G A 7: 25,058,627 (GRCm39) V2208I probably benign Het
Neto2 G A 8: 86,400,747 (GRCm39) T16I probably damaging Het
Nktr T A 9: 121,578,135 (GRCm39) probably benign Het
Nrxn1 A G 17: 90,515,849 (GRCm39) I1207T probably damaging Het
Obox7 G A 7: 14,397,972 (GRCm39) G4D probably benign Het
Ogdh G A 11: 6,300,655 (GRCm39) W827* probably null Het
Or4c118 T A 2: 88,974,474 (GRCm39) K298* probably null Het
Or4k15c A G 14: 50,321,173 (GRCm39) *322Q probably null Het
Pcdhga9 G A 18: 37,871,995 (GRCm39) R608H probably benign Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Sbpl T A 17: 24,172,617 (GRCm39) I101L probably benign Het
Serpina9 T A 12: 103,975,151 (GRCm39) M1L probably benign Het
Stxbp6 A G 12: 44,949,641 (GRCm39) probably null Het
Synpo2 A G 3: 122,908,239 (GRCm39) V359A probably damaging Het
Ttyh1 T A 7: 4,132,317 (GRCm39) L155H probably damaging Het
Vil1 A G 1: 74,471,574 (GRCm39) D785G probably benign Het
Zfp345 G A 2: 150,314,473 (GRCm39) H355Y probably damaging Het
Other mutations in Or13g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Or13g1 APN 7 85,956,259 (GRCm39) missense probably damaging 1.00
R0370:Or13g1 UTSW 7 85,956,057 (GRCm39) missense probably benign 0.42
R1869:Or13g1 UTSW 7 85,955,875 (GRCm39) missense possibly damaging 0.96
R2047:Or13g1 UTSW 7 85,956,012 (GRCm39) missense probably damaging 1.00
R4562:Or13g1 UTSW 7 85,956,360 (GRCm39) start gained probably benign
R4640:Or13g1 UTSW 7 85,956,274 (GRCm39) missense probably benign 0.01
R4811:Or13g1 UTSW 7 85,956,166 (GRCm39) missense probably benign 0.41
R4867:Or13g1 UTSW 7 85,955,491 (GRCm39) missense probably benign 0.00
R4954:Or13g1 UTSW 7 85,955,809 (GRCm39) missense probably benign 0.01
R5784:Or13g1 UTSW 7 85,955,743 (GRCm39) missense probably damaging 1.00
R6043:Or13g1 UTSW 7 85,955,547 (GRCm39) missense probably damaging 0.97
R6498:Or13g1 UTSW 7 85,956,226 (GRCm39) missense probably benign
R6849:Or13g1 UTSW 7 85,956,248 (GRCm39) missense possibly damaging 0.54
R7238:Or13g1 UTSW 7 85,955,799 (GRCm39) missense probably damaging 1.00
R7811:Or13g1 UTSW 7 85,955,554 (GRCm39) missense probably damaging 1.00
R7917:Or13g1 UTSW 7 85,955,686 (GRCm39) missense probably damaging 1.00
R8010:Or13g1 UTSW 7 85,956,260 (GRCm39) missense probably benign 0.24
R8271:Or13g1 UTSW 7 85,955,962 (GRCm39) missense probably benign 0.13
R9017:Or13g1 UTSW 7 85,955,957 (GRCm39) nonsense probably null
R9150:Or13g1 UTSW 7 85,955,942 (GRCm39) missense probably damaging 0.96
T0975:Or13g1 UTSW 7 85,955,492 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAAGGAAGCCTATTAGTTGATGCC -3'
(R):5'- AGAAGGCCTTCTCTACGTGC -3'

Sequencing Primer
(F):5'- GATGCCTTAAAGTATTTGAAGTTGCC -3'
(R):5'- GCTCATCGCACCTCATGG -3'
Posted On 2015-04-17