Incidental Mutation 'R3879:Or10ad1b'
ID 308695
Institutional Source Beutler Lab
Gene Symbol Or10ad1b
Ensembl Gene ENSMUSG00000059460
Gene Name olfactory receptor family 10 subfamily AD member 1B
Synonyms Olfr286, GA_x6K02T2NBG7-5528233-5529186, EG629524, MOR286-2
MMRRC Submission 040793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R3879 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 98124556-98132331 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 98125085 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 147 (C147Y)
Ref Sequence ENSEMBL: ENSMUSP00000154542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073612] [ENSMUST00000205305]
AlphaFold A0A2I3BRI6
Predicted Effect probably damaging
Transcript: ENSMUST00000073612
AA Change: C149Y

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000073296
Gene: ENSMUSG00000059460
AA Change: C149Y

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 2.6e-52 PFAM
Pfam:7tm_1 47 296 2.4e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000073612
AA Change: C149Y

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000205305
AA Change: C147Y

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206621
Meta Mutation Damage Score 0.4666 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 95% (38/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933434E20Rik T C 3: 89,970,561 (GRCm39) probably benign Het
Aass G A 6: 23,122,520 (GRCm39) H68Y probably damaging Het
Abcc8 T A 7: 45,754,051 (GRCm39) K1588N possibly damaging Het
Calcoco1 T C 15: 102,615,823 (GRCm39) D601G probably damaging Het
Ccdc175 C A 12: 72,182,792 (GRCm39) R409I probably damaging Het
Ccnl1 A G 3: 65,856,179 (GRCm39) V242A possibly damaging Het
Clasp2 T C 9: 113,719,029 (GRCm39) F705L probably damaging Het
Cyp46a1 A G 12: 108,324,389 (GRCm39) T389A probably benign Het
Eps8 A G 6: 137,504,360 (GRCm39) probably benign Het
Gm9894 T C 13: 67,912,916 (GRCm39) noncoding transcript Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Nup153 A T 13: 46,837,436 (GRCm39) V1262E probably damaging Het
Nup210l A G 3: 90,092,780 (GRCm39) T1245A probably damaging Het
Or5b121 A G 19: 13,507,613 (GRCm39) Y236C probably damaging Het
Pcif1 G A 2: 164,727,878 (GRCm39) G189D probably benign Het
Pdzd2 A G 15: 12,375,594 (GRCm39) S1514P probably damaging Het
Pigu A T 2: 155,141,063 (GRCm39) F276I probably damaging Het
Pramex1 T C X: 134,514,194 (GRCm39) H365R probably benign Het
Psmd9 C T 5: 123,372,653 (GRCm39) probably benign Het
Rasgrp2 A T 19: 6,463,920 (GRCm39) Q539H probably benign Het
Rgs22 T G 15: 36,107,051 (GRCm39) I112L possibly damaging Het
Slc26a9 A T 1: 131,696,969 (GRCm39) T786S probably benign Het
Sned1 A G 1: 93,192,752 (GRCm39) probably benign Het
St7l G A 3: 104,833,763 (GRCm39) V475I probably damaging Het
Tnfrsf11a C T 1: 105,737,085 (GRCm39) T64I probably damaging Het
Top3a A G 11: 60,634,765 (GRCm39) V713A possibly damaging Het
Trim16 G A 11: 62,731,433 (GRCm39) G348S probably damaging Het
Tshz3 C T 7: 36,470,962 (GRCm39) Q984* probably null Het
Ttn A G 2: 76,566,406 (GRCm39) probably null Het
Ubfd1 T A 7: 121,667,999 (GRCm39) probably benign Het
Zfp37 A T 4: 62,109,572 (GRCm39) Y497* probably null Het
Zfp462 G A 4: 55,060,095 (GRCm39) C1207Y probably damaging Het
Zfp607b A G 7: 27,403,476 (GRCm39) E644G possibly damaging Het
Other mutations in Or10ad1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02436:Or10ad1b APN 15 98,125,171 (GRCm39) nonsense probably null
IGL02850:Or10ad1b APN 15 98,125,232 (GRCm39) missense probably benign 0.01
R1833:Or10ad1b UTSW 15 98,124,846 (GRCm39) missense probably damaging 1.00
R4854:Or10ad1b UTSW 15 98,125,425 (GRCm39) missense possibly damaging 0.93
R4866:Or10ad1b UTSW 15 98,125,371 (GRCm39) missense probably damaging 1.00
R5076:Or10ad1b UTSW 15 98,124,642 (GRCm39) missense probably damaging 1.00
R5886:Or10ad1b UTSW 15 98,124,672 (GRCm39) missense possibly damaging 0.83
R7090:Or10ad1b UTSW 15 98,125,083 (GRCm39) missense probably benign 0.00
R9378:Or10ad1b UTSW 15 98,124,920 (GRCm39) missense possibly damaging 0.94
R9405:Or10ad1b UTSW 15 98,124,912 (GRCm39) missense possibly damaging 0.88
R9715:Or10ad1b UTSW 15 98,124,902 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACAATGAGCACCATGGGACTG -3'
(R):5'- TTGGTCCATCTGGTGACCAAG -3'

Sequencing Primer
(F):5'- GCACCATGGGACTGAGCAAC -3'
(R):5'- AAGAACCACACTGTCTCCTTTG -3'
Posted On 2015-04-17