Incidental Mutation 'R3881:Mier2'
ID 308773
Institutional Source Beutler Lab
Gene Symbol Mier2
Ensembl Gene ENSMUSG00000042570
Gene Name MIER family member 2
Synonyms 2700087H15Rik
MMRRC Submission 040795-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.350) question?
Stock # R3881 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 79376079-79391033 bp(-) (GRCm39)
Type of Mutation splice site (808 bp from exon)
DNA Base Change (assembly) C to T at 79384584 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062855] [ENSMUST00000062855] [ENSMUST00000164895] [ENSMUST00000165028] [ENSMUST00000165028] [ENSMUST00000165778] [ENSMUST00000165866] [ENSMUST00000167183] [ENSMUST00000170018] [ENSMUST00000167689]
AlphaFold Q3U3N0
Predicted Effect probably null
Transcript: ENSMUST00000062855
SMART Domains Protein: ENSMUSP00000059864
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
ELM2 194 246 1.46e-9 SMART
SANT 295 344 6.01e-8 SMART
low complexity region 441 458 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000062855
SMART Domains Protein: ENSMUSP00000059864
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
ELM2 194 246 1.46e-9 SMART
SANT 295 344 6.01e-8 SMART
low complexity region 441 458 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000164895
Predicted Effect probably null
Transcript: ENSMUST00000165028
SMART Domains Protein: ENSMUSP00000127387
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
ELM2 196 248 1.46e-9 SMART
SANT 297 346 6.01e-8 SMART
low complexity region 443 460 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000165028
SMART Domains Protein: ENSMUSP00000127387
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
ELM2 196 248 1.46e-9 SMART
SANT 297 346 6.01e-8 SMART
low complexity region 443 460 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000165778
Predicted Effect probably null
Transcript: ENSMUST00000165866
SMART Domains Protein: ENSMUSP00000127332
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 42 64 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167183
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167760
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170950
Predicted Effect probably null
Transcript: ENSMUST00000170018
Predicted Effect probably null
Transcript: ENSMUST00000167689
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010003K11Rik T G 19: 4,548,417 (GRCm39) K44T possibly damaging Het
4933402N03Rik T C 7: 130,740,823 (GRCm39) E131G probably benign Het
Angptl4 G A 17: 33,996,008 (GRCm39) P323S possibly damaging Het
Cep41 A G 6: 30,658,397 (GRCm39) S201P probably damaging Het
Cep95 A G 11: 106,697,118 (GRCm39) I257V probably damaging Het
Clca4a T C 3: 144,663,079 (GRCm39) N590S probably benign Het
Cyfip2 A G 11: 46,099,162 (GRCm39) L716P probably damaging Het
Cyp2d34 T A 15: 82,502,818 (GRCm39) Q136L probably benign Het
Def6 T C 17: 28,439,189 (GRCm39) C267R probably damaging Het
Dgat2 G A 7: 98,818,950 (GRCm39) Q69* probably null Het
Dlgap1 T A 17: 71,093,810 (GRCm39) S710R probably damaging Het
Dnah10 T C 5: 124,850,095 (GRCm39) I1539T probably benign Het
Dnah2 T A 11: 69,342,173 (GRCm39) I2932F possibly damaging Het
Enpp2 A G 15: 54,783,088 (GRCm39) S76P probably damaging Het
Esr2 T C 12: 76,214,394 (GRCm39) D19G probably damaging Het
Fam13b A T 18: 34,595,112 (GRCm39) probably null Het
Fbxw14 A T 9: 109,100,262 (GRCm39) V464D possibly damaging Het
Fcgbpl1 T A 7: 27,839,463 (GRCm39) C425* probably null Het
Gm21961 A G 15: 64,886,716 (GRCm39) probably null Het
Gpd2 C T 2: 57,228,987 (GRCm39) R264* probably null Het
Hps5 A G 7: 46,421,420 (GRCm39) V648A possibly damaging Het
Ints4 A G 7: 97,165,464 (GRCm39) T517A possibly damaging Het
Itpr3 A G 17: 27,332,814 (GRCm39) N1860S probably benign Het
Itsn2 G A 12: 4,684,546 (GRCm39) probably benign Het
Jup A G 11: 100,269,207 (GRCm39) V402A probably benign Het
Letm2 C A 8: 26,083,884 (GRCm39) E116* probably null Het
Ly6c1 T C 15: 74,917,436 (GRCm39) T71A probably benign Het
Mcm3ap G A 10: 76,342,280 (GRCm39) S1591N probably benign Het
Mocs2 T A 13: 114,955,882 (GRCm39) L10* probably null Het
Myo6 A G 9: 80,171,538 (GRCm39) D513G probably damaging Het
Myoz2 T C 3: 122,807,369 (GRCm39) Y147C probably damaging Het
Nin C T 12: 70,089,315 (GRCm39) V1367M probably benign Het
Nr2f6 C T 8: 71,828,675 (GRCm39) A200T probably damaging Het
Obscn C T 11: 58,947,775 (GRCm39) C4418Y probably damaging Het
Or10ak9 A G 4: 118,726,550 (GRCm39) M191V probably benign Het
Or10q12 T C 19: 13,746,144 (GRCm39) V146A probably benign Het
Or5g26 T A 2: 85,494,769 (GRCm39) H3L probably benign Het
Paxip1 C T 5: 27,953,837 (GRCm39) R953Q probably damaging Het
Pcdha1 A T 18: 37,064,454 (GRCm39) I373F possibly damaging Het
Pcdha7 G A 18: 37,108,432 (GRCm39) E486K probably benign Het
Recql5 G A 11: 115,784,780 (GRCm39) P849L probably benign Het
Recql5 G T 11: 115,784,781 (GRCm39) P849T probably benign Het
Rnf180 A T 13: 105,386,915 (GRCm39) M131K possibly damaging Het
Rplp1 A G 9: 61,821,704 (GRCm39) S3P probably benign Het
Rpp38 T A 2: 3,330,283 (GRCm39) R206S probably benign Het
Sdha G T 13: 74,487,311 (GRCm39) P159Q probably damaging Het
Shank2 T C 7: 143,959,121 (GRCm39) V199A probably benign Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Timm50 C A 7: 28,010,432 (GRCm39) A41S probably benign Het
Tmbim1 A G 1: 74,329,157 (GRCm39) probably benign Het
Tmprss11a C T 5: 86,593,664 (GRCm39) V29M possibly damaging Het
Ttc28 A T 5: 111,331,106 (GRCm39) H411L probably damaging Het
Ube4b A T 4: 149,449,861 (GRCm39) probably null Het
Zdhhc22 T A 12: 87,030,400 (GRCm39) M183L probably benign Het
Zfp106 A G 2: 120,362,630 (GRCm39) S830P probably benign Het
Other mutations in Mier2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01412:Mier2 APN 10 79,377,014 (GRCm39) makesense probably null
IGL01761:Mier2 APN 10 79,384,186 (GRCm39) critical splice donor site probably null
IGL01845:Mier2 APN 10 79,385,418 (GRCm39) missense possibly damaging 0.69
IGL02336:Mier2 APN 10 79,384,184 (GRCm39) unclassified probably benign
IGL02882:Mier2 APN 10 79,383,555 (GRCm39) missense probably damaging 1.00
IGL02902:Mier2 APN 10 79,385,456 (GRCm39) missense probably damaging 1.00
R0325:Mier2 UTSW 10 79,378,430 (GRCm39) critical splice donor site probably null
R0972:Mier2 UTSW 10 79,380,455 (GRCm39) unclassified probably benign
R1326:Mier2 UTSW 10 79,380,543 (GRCm39) missense probably damaging 1.00
R1333:Mier2 UTSW 10 79,380,991 (GRCm39) missense probably benign 0.03
R1721:Mier2 UTSW 10 79,384,664 (GRCm39) missense probably damaging 1.00
R1867:Mier2 UTSW 10 79,384,664 (GRCm39) missense probably damaging 1.00
R1868:Mier2 UTSW 10 79,384,664 (GRCm39) missense probably damaging 1.00
R2015:Mier2 UTSW 10 79,377,036 (GRCm39) splice site probably null
R2273:Mier2 UTSW 10 79,380,368 (GRCm39) missense probably damaging 1.00
R2274:Mier2 UTSW 10 79,380,368 (GRCm39) missense probably damaging 1.00
R3729:Mier2 UTSW 10 79,380,876 (GRCm39) unclassified probably benign
R3874:Mier2 UTSW 10 79,377,631 (GRCm39) missense possibly damaging 0.49
R4755:Mier2 UTSW 10 79,385,031 (GRCm39) missense probably damaging 1.00
R4758:Mier2 UTSW 10 79,386,182 (GRCm39) missense probably damaging 1.00
R5070:Mier2 UTSW 10 79,385,411 (GRCm39) missense probably benign 0.03
R6282:Mier2 UTSW 10 79,380,576 (GRCm39) missense probably damaging 1.00
R6785:Mier2 UTSW 10 79,380,547 (GRCm39) missense probably damaging 1.00
R6861:Mier2 UTSW 10 79,376,990 (GRCm39) start gained probably benign
R6869:Mier2 UTSW 10 79,378,503 (GRCm39) missense probably damaging 0.99
R6897:Mier2 UTSW 10 79,380,573 (GRCm39) missense probably damaging 0.99
R6902:Mier2 UTSW 10 79,376,673 (GRCm39) utr 3 prime probably benign
R6946:Mier2 UTSW 10 79,376,673 (GRCm39) utr 3 prime probably benign
R6968:Mier2 UTSW 10 79,376,476 (GRCm39) utr 3 prime probably benign
R6971:Mier2 UTSW 10 79,378,263 (GRCm39) missense possibly damaging 0.53
R7072:Mier2 UTSW 10 79,376,133 (GRCm39) missense unknown
R7350:Mier2 UTSW 10 79,376,132 (GRCm39) missense unknown
R7443:Mier2 UTSW 10 79,376,289 (GRCm39) missense unknown
R7506:Mier2 UTSW 10 79,386,176 (GRCm39) missense probably benign 0.14
R7545:Mier2 UTSW 10 79,377,028 (GRCm39) missense possibly damaging 0.79
R7625:Mier2 UTSW 10 79,378,543 (GRCm39) missense probably damaging 1.00
R7669:Mier2 UTSW 10 79,385,510 (GRCm39) missense probably damaging 1.00
R7895:Mier2 UTSW 10 79,377,719 (GRCm39) start gained probably benign
R8494:Mier2 UTSW 10 79,377,546 (GRCm39) missense probably damaging 1.00
R8520:Mier2 UTSW 10 79,378,263 (GRCm39) missense possibly damaging 0.53
R8834:Mier2 UTSW 10 79,386,293 (GRCm39) missense unknown
R8978:Mier2 UTSW 10 79,376,790 (GRCm39) missense unknown
R9005:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9007:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9008:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9018:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9051:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9052:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9108:Mier2 UTSW 10 79,377,756 (GRCm39) missense probably benign 0.01
R9111:Mier2 UTSW 10 79,381,285 (GRCm39) unclassified probably benign
R9121:Mier2 UTSW 10 79,377,594 (GRCm39) missense
R9281:Mier2 UTSW 10 79,378,294 (GRCm39) missense probably benign 0.06
R9514:Mier2 UTSW 10 79,377,496 (GRCm39) missense probably benign 0.00
Z1176:Mier2 UTSW 10 79,376,335 (GRCm39) missense unknown
Z1177:Mier2 UTSW 10 79,376,295 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGGATGGCAACTCATCTTGC -3'
(R):5'- CGTTTACTGTCCTGTTCAAAGG -3'

Sequencing Primer
(F):5'- TGGAGAGCACCTGACAGTCTG -3'
(R):5'- CTTGCTTTCTGGGGAAGA -3'
Posted On 2015-04-17