Incidental Mutation 'R0379:Brd9'
ID 30892
Institutional Source Beutler Lab
Gene Symbol Brd9
Ensembl Gene ENSMUSG00000057649
Gene Name bromodomain containing 9
Synonyms
MMRRC Submission 038585-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0379 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 74085930-74109014 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 74090802 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152627 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022053] [ENSMUST00000099384] [ENSMUST00000222399] [ENSMUST00000223238] [ENSMUST00000222749]
AlphaFold Q3UQU0
Predicted Effect probably benign
Transcript: ENSMUST00000022053
SMART Domains Protein: ENSMUSP00000022053
Gene: ENSMUSG00000021569

DomainStartEndE-ValueType
AAA 171 323 1.13e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099384
SMART Domains Protein: ENSMUSP00000096982
Gene: ENSMUSG00000057649

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
coiled coil region 53 104 N/A INTRINSIC
low complexity region 116 127 N/A INTRINSIC
BROMO 134 242 1.52e-30 SMART
low complexity region 249 264 N/A INTRINSIC
Pfam:DUF3512 274 505 1.6e-82 PFAM
low complexity region 544 557 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220488
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220968
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222191
Predicted Effect probably benign
Transcript: ENSMUST00000222399
Predicted Effect unknown
Transcript: ENSMUST00000223525
AA Change: F171S
Predicted Effect probably benign
Transcript: ENSMUST00000223238
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223455
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223063
Predicted Effect probably benign
Transcript: ENSMUST00000222749
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223446
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.9%
Validation Efficiency 98% (79/81)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930512M02Rik A G 11: 11,539,365 (GRCm39) probably benign Het
Apba1 A C 19: 23,912,194 (GRCm39) N558T probably damaging Het
Arfgef2 T A 2: 166,702,320 (GRCm39) probably null Het
Arsb T C 13: 94,077,135 (GRCm39) S501P probably benign Het
Atp10b A G 11: 43,145,141 (GRCm39) T1295A probably benign Het
Atp8b5 G T 4: 43,361,898 (GRCm39) R648L probably damaging Het
Bcl2a1b T C 9: 89,081,789 (GRCm39) I126T possibly damaging Het
Cd93 T C 2: 148,283,430 (GRCm39) probably benign Het
Chd5 A G 4: 152,467,778 (GRCm39) K1692R probably benign Het
Clcn4 T C 7: 7,299,791 (GRCm39) T13A probably damaging Het
Clec14a A G 12: 58,315,580 (GRCm39) F14S possibly damaging Het
Clec4g A G 8: 3,768,440 (GRCm39) V97A probably benign Het
Col24a1 G A 3: 145,229,897 (GRCm39) R1483K possibly damaging Het
Crem A T 18: 3,299,226 (GRCm39) V82D probably damaging Het
Ctnna2 T A 6: 77,618,423 (GRCm39) T180S probably benign Het
Cybrd1 T C 2: 70,960,099 (GRCm39) I99T probably benign Het
Cyp4a32 G A 4: 115,478,671 (GRCm39) V468M probably damaging Het
Dlk1 A G 12: 109,420,985 (GRCm39) probably benign Het
Dnaaf9 C T 2: 130,627,466 (GRCm39) probably benign Het
Dnah7b A T 1: 46,179,336 (GRCm39) Y1003F probably benign Het
Egfem1 A C 3: 29,722,399 (GRCm39) E376A possibly damaging Het
Etl4 T A 2: 20,812,165 (GRCm39) I1416K probably damaging Het
Fbxl4 A G 4: 22,386,106 (GRCm39) T238A probably benign Het
Fer1l6 A G 15: 58,420,187 (GRCm39) I33M probably benign Het
Fndc3a A G 14: 72,794,049 (GRCm39) S830P probably damaging Het
Fras1 C T 5: 96,903,368 (GRCm39) R3082* probably null Het
Galnt13 T C 2: 54,950,504 (GRCm39) V395A possibly damaging Het
Gpd2 C T 2: 57,235,275 (GRCm39) T335I probably damaging Het
Gucy2d C A 7: 98,108,209 (GRCm39) probably null Het
Hydin A G 8: 111,235,759 (GRCm39) probably benign Het
Ints5 G T 19: 8,874,497 (GRCm39) V819L possibly damaging Het
Klhdc10 C G 6: 30,450,669 (GRCm39) Q292E possibly damaging Het
Lmbrd2 G A 15: 9,149,566 (GRCm39) A67T probably benign Het
Lrp1 T G 10: 127,430,838 (GRCm39) T404P probably damaging Het
Marchf7 T C 2: 60,064,470 (GRCm39) S249P probably benign Het
Mcm10 T A 2: 5,013,434 (GRCm39) K66M probably benign Het
Mtmr7 C A 8: 41,004,642 (GRCm39) D645Y probably damaging Het
Muc6 T A 7: 141,216,868 (GRCm39) I2602F possibly damaging Het
Myh13 G A 11: 67,260,121 (GRCm39) probably benign Het
Myo18a G A 11: 77,741,632 (GRCm39) V1776I possibly damaging Het
Ncapg2 T C 12: 116,406,695 (GRCm39) L957S probably damaging Het
Ncoa3 T C 2: 165,896,422 (GRCm39) S442P probably damaging Het
Or5t5 G A 2: 86,616,079 (GRCm39) E2K probably benign Het
Or6x1 G A 9: 40,098,729 (GRCm39) G106D probably damaging Het
Or7g32 T A 9: 19,388,776 (GRCm39) T257S possibly damaging Het
Pdcd6 G T 13: 74,457,831 (GRCm39) N113K possibly damaging Het
Pfkfb4 C T 9: 108,856,810 (GRCm39) probably benign Het
Pfkm A G 15: 98,024,195 (GRCm39) H401R probably benign Het
Phldb2 C A 16: 45,601,814 (GRCm39) D754Y probably damaging Het
Plekhb2 T A 1: 34,902,195 (GRCm39) M49K probably damaging Het
Polrmt A G 10: 79,573,445 (GRCm39) S1057P possibly damaging Het
Prps1l1 A G 12: 35,035,077 (GRCm39) N64S probably benign Het
Prss3l T G 6: 41,422,190 (GRCm39) probably benign Het
Psg16 T C 7: 16,864,583 (GRCm39) S393P probably benign Het
Rundc1 C T 11: 101,315,973 (GRCm39) T15I probably benign Het
Scaf11 A G 15: 96,329,697 (GRCm39) L143S probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Serpinf1 T G 11: 75,304,771 (GRCm39) I197L probably benign Het
Siglec1 C T 2: 130,916,445 (GRCm39) probably benign Het
Slc28a1 G A 7: 80,787,925 (GRCm39) V271I probably benign Het
Sntg1 T C 1: 8,853,048 (GRCm39) D34G probably damaging Het
Sptbn4 A T 7: 27,059,161 (GRCm39) probably benign Het
Suclg1 T C 6: 73,233,211 (GRCm39) I51T possibly damaging Het
Syne1 C T 10: 5,491,989 (GRCm39) R9Q probably damaging Het
Trim47 T A 11: 115,997,344 (GRCm39) H470L probably damaging Het
Ttc41 T A 10: 86,548,841 (GRCm39) Y12N possibly damaging Het
Tubgcp2 T C 7: 139,612,105 (GRCm39) E69G probably damaging Het
Tubgcp3 G A 8: 12,691,116 (GRCm39) T474M probably damaging Het
Ubr5 A T 15: 38,019,201 (GRCm39) N777K probably benign Het
Ush2a T C 1: 188,184,016 (GRCm39) L1440P probably damaging Het
Usp28 A C 9: 48,935,367 (GRCm39) D458A possibly damaging Het
Vcan A T 13: 89,851,665 (GRCm39) D1098E probably damaging Het
Vmn1r73 C T 7: 11,490,773 (GRCm39) T197I probably benign Het
Vmn2r15 T C 5: 109,434,344 (GRCm39) S787G probably damaging Het
Vmn2r90 T A 17: 17,948,401 (GRCm39) I549N probably damaging Het
Vps33b T A 7: 79,933,162 (GRCm39) probably null Het
Zfp516 A T 18: 83,005,795 (GRCm39) K900* probably null Het
Zfp974 T A 7: 27,610,357 (GRCm39) N456I probably damaging Het
Other mutations in Brd9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Brd9 APN 13 74,086,666 (GRCm39) missense probably damaging 0.98
IGL01461:Brd9 APN 13 74,099,717 (GRCm39) nonsense probably null
IGL01928:Brd9 APN 13 74,103,630 (GRCm39) missense probably benign 0.02
R0420:Brd9 UTSW 13 74,103,592 (GRCm39) missense probably benign
R0788:Brd9 UTSW 13 74,092,986 (GRCm39) splice site probably benign
R1539:Brd9 UTSW 13 74,092,862 (GRCm39) missense probably damaging 0.99
R4095:Brd9 UTSW 13 74,092,918 (GRCm39) missense probably benign 0.19
R4582:Brd9 UTSW 13 74,095,852 (GRCm39) missense probably benign 0.00
R4648:Brd9 UTSW 13 74,088,895 (GRCm39) missense probably benign 0.37
R4915:Brd9 UTSW 13 74,086,574 (GRCm39) missense probably damaging 0.99
R6054:Brd9 UTSW 13 74,088,860 (GRCm39) missense probably damaging 1.00
R6175:Brd9 UTSW 13 74,108,433 (GRCm39) missense probably damaging 0.98
R6462:Brd9 UTSW 13 74,088,788 (GRCm39) missense probably damaging 1.00
R6520:Brd9 UTSW 13 74,090,913 (GRCm39) missense probably benign 0.00
R7217:Brd9 UTSW 13 74,087,063 (GRCm39) missense probably damaging 1.00
R7360:Brd9 UTSW 13 74,092,942 (GRCm39) missense probably benign 0.07
R7422:Brd9 UTSW 13 74,102,697 (GRCm39) missense probably benign
R7556:Brd9 UTSW 13 74,092,886 (GRCm39) missense possibly damaging 0.83
R7844:Brd9 UTSW 13 74,086,652 (GRCm39) missense probably damaging 1.00
R9130:Brd9 UTSW 13 74,092,906 (GRCm39) missense probably damaging 0.97
Z1176:Brd9 UTSW 13 74,092,870 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGGGCCAAACCTTGAATGCTG -3'
(R):5'- AGGGGCTGCTGGAACCTAAGAATC -3'

Sequencing Primer
(F):5'- ACCTTGAATGCTGAGCCC -3'
(R):5'- CTGCTGGAACCTAAGAATCCTTAGAG -3'
Posted On 2013-04-24