Incidental Mutation 'R3901:Tgfbr3'
| ID |
308977 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tgfbr3
|
| Ensembl Gene |
ENSMUSG00000029287 |
| Gene Name |
transforming growth factor, beta receptor III |
| Synonyms |
betaglycan, TBRIII, 1110036H20Rik |
| MMRRC Submission |
040810-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R3901 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
107254436-107437495 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 107362753 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031224
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031224]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000031224
|
| SMART Domains |
Protein: ENSMUSP00000031224
Gene: ENSMUSG00000029287
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
64 |
193 |
2.48e-5 |
PROSPERO |
|
internal_repeat_1
|
232 |
361 |
2.48e-5 |
PROSPERO |
|
low complexity region
|
419 |
430 |
N/A |
INTRINSIC |
|
ZP
|
454 |
731 |
8.12e-65 |
SMART |
|
transmembrane domain
|
786 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
835 |
849 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146591
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
98% (39/40) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
PHENOTYPE: Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts20 |
T |
A |
15: 94,226,726 (GRCm39) |
D1109V |
possibly damaging |
Het |
| Apc2 |
G |
C |
10: 80,150,922 (GRCm39) |
R1992P |
possibly damaging |
Het |
| Atmin |
A |
G |
8: 117,683,036 (GRCm39) |
N232S |
probably benign |
Het |
| Brat1 |
A |
C |
5: 140,703,751 (GRCm39) |
D668A |
possibly damaging |
Het |
| Casp16 |
A |
T |
17: 23,771,922 (GRCm39) |
V101E |
probably damaging |
Het |
| Cass4 |
C |
T |
2: 172,274,478 (GRCm39) |
P753L |
probably damaging |
Het |
| Cimip3 |
AC |
A |
17: 47,744,348 (GRCm39) |
|
probably benign |
Het |
| Clec7a |
A |
G |
6: 129,445,877 (GRCm39) |
S98P |
possibly damaging |
Het |
| Cpne5 |
G |
A |
17: 29,378,082 (GRCm39) |
R566C |
unknown |
Het |
| Csrnp1 |
C |
T |
9: 119,801,707 (GRCm39) |
E451K |
probably damaging |
Het |
| Dlst |
A |
G |
12: 85,179,465 (GRCm39) |
T435A |
possibly damaging |
Het |
| Dock8 |
A |
G |
19: 25,078,269 (GRCm39) |
T525A |
possibly damaging |
Het |
| Dync2li1 |
A |
G |
17: 84,939,070 (GRCm39) |
T45A |
probably damaging |
Het |
| Efcab3 |
A |
G |
11: 104,974,713 (GRCm39) |
N5307S |
possibly damaging |
Het |
| Epha4 |
A |
G |
1: 77,357,539 (GRCm39) |
Y820H |
probably damaging |
Het |
| F5 |
A |
G |
1: 164,003,798 (GRCm39) |
T198A |
probably benign |
Het |
| Fbn2 |
T |
A |
18: 58,199,083 (GRCm39) |
N1395I |
probably damaging |
Het |
| Fcnb |
T |
A |
2: 27,969,208 (GRCm39) |
Y163F |
probably damaging |
Het |
| Gm5444 |
T |
C |
13: 4,884,278 (GRCm39) |
|
noncoding transcript |
Het |
| Jph3 |
G |
T |
8: 122,480,158 (GRCm39) |
D279Y |
possibly damaging |
Het |
| Kcnj3 |
A |
G |
2: 55,327,360 (GRCm39) |
N50D |
possibly damaging |
Het |
| Kcnma1 |
A |
G |
14: 23,555,323 (GRCm39) |
I416T |
probably damaging |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Kmt2e |
A |
G |
5: 23,706,640 (GRCm39) |
N1401S |
probably benign |
Het |
| Lama5 |
C |
T |
2: 179,824,144 (GRCm39) |
|
probably benign |
Het |
| Lrp1b |
A |
G |
2: 40,712,707 (GRCm39) |
V3095A |
probably damaging |
Het |
| Mmp1a |
A |
G |
9: 7,475,346 (GRCm39) |
*372W |
probably null |
Het |
| Or7d11 |
C |
T |
9: 19,966,169 (GRCm39) |
V197I |
probably benign |
Het |
| Pdgfra |
T |
A |
5: 75,353,169 (GRCm39) |
N986K |
probably benign |
Het |
| Pgap1 |
C |
T |
1: 54,532,507 (GRCm39) |
V671I |
probably benign |
Het |
| Pla2g4e |
T |
C |
2: 119,999,085 (GRCm39) |
S760G |
probably benign |
Het |
| Plk3 |
T |
C |
4: 116,990,633 (GRCm39) |
I94V |
probably benign |
Het |
| Pogk |
C |
T |
1: 166,231,193 (GRCm39) |
V45I |
probably damaging |
Het |
| Pou2f1 |
G |
C |
1: 165,722,538 (GRCm39) |
P349R |
probably damaging |
Het |
| Rims1 |
T |
A |
1: 22,572,578 (GRCm39) |
Q541L |
probably benign |
Het |
| Rptn |
A |
G |
3: 93,305,664 (GRCm39) |
Q999R |
probably benign |
Het |
| Stxbp5 |
A |
G |
10: 9,645,163 (GRCm39) |
L911P |
probably damaging |
Het |
| Trim7 |
A |
T |
11: 48,728,435 (GRCm39) |
T28S |
probably damaging |
Het |
| Zfp595 |
T |
C |
13: 67,465,379 (GRCm39) |
I295V |
probably benign |
Het |
|
| Other mutations in Tgfbr3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00966:Tgfbr3
|
APN |
5 |
107,290,367 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01135:Tgfbr3
|
APN |
5 |
107,362,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01375:Tgfbr3
|
APN |
5 |
107,284,837 (GRCm39) |
missense |
probably benign |
|
|
IGL01457:Tgfbr3
|
APN |
5 |
107,297,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01599:Tgfbr3
|
APN |
5 |
107,266,317 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01646:Tgfbr3
|
APN |
5 |
107,269,279 (GRCm39) |
splice site |
probably benign |
|
|
IGL01945:Tgfbr3
|
APN |
5 |
107,269,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03039:Tgfbr3
|
APN |
5 |
107,325,665 (GRCm39) |
splice site |
probably benign |
|
|
IGL03202:Tgfbr3
|
APN |
5 |
107,257,630 (GRCm39) |
splice site |
probably benign |
|
|
IGL03378:Tgfbr3
|
APN |
5 |
107,257,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Tgfbr3
|
UTSW |
5 |
107,280,682 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0452:Tgfbr3
|
UTSW |
5 |
107,288,289 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0665:Tgfbr3
|
UTSW |
5 |
107,325,716 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0667:Tgfbr3
|
UTSW |
5 |
107,325,716 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0751:Tgfbr3
|
UTSW |
5 |
107,287,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1373:Tgfbr3
|
UTSW |
5 |
107,362,809 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1777:Tgfbr3
|
UTSW |
5 |
107,284,796 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1887:Tgfbr3
|
UTSW |
5 |
107,284,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3019:Tgfbr3
|
UTSW |
5 |
107,285,412 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R3552:Tgfbr3
|
UTSW |
5 |
107,287,705 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3617:Tgfbr3
|
UTSW |
5 |
107,288,485 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4830:Tgfbr3
|
UTSW |
5 |
107,257,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Tgfbr3
|
UTSW |
5 |
107,278,335 (GRCm39) |
missense |
probably benign |
|
|
R5020:Tgfbr3
|
UTSW |
5 |
107,362,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5044:Tgfbr3
|
UTSW |
5 |
107,284,795 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5619:Tgfbr3
|
UTSW |
5 |
107,288,380 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5752:Tgfbr3
|
UTSW |
5 |
107,287,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5768:Tgfbr3
|
UTSW |
5 |
107,297,761 (GRCm39) |
missense |
probably benign |
|
|
R5799:Tgfbr3
|
UTSW |
5 |
107,257,474 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5818:Tgfbr3
|
UTSW |
5 |
107,280,869 (GRCm39) |
missense |
probably benign |
|
|
R5846:Tgfbr3
|
UTSW |
5 |
107,288,521 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5859:Tgfbr3
|
UTSW |
5 |
107,288,381 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Tgfbr3
|
UTSW |
5 |
107,266,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6378:Tgfbr3
|
UTSW |
5 |
107,325,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Tgfbr3
|
UTSW |
5 |
107,284,796 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6823:Tgfbr3
|
UTSW |
5 |
107,297,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6994:Tgfbr3
|
UTSW |
5 |
107,280,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7454:Tgfbr3
|
UTSW |
5 |
107,362,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7773:Tgfbr3
|
UTSW |
5 |
107,288,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7978:Tgfbr3
|
UTSW |
5 |
107,287,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8201:Tgfbr3
|
UTSW |
5 |
107,278,431 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8296:Tgfbr3
|
UTSW |
5 |
107,287,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8758:Tgfbr3
|
UTSW |
5 |
107,297,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9232:Tgfbr3
|
UTSW |
5 |
107,290,361 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9360:Tgfbr3
|
UTSW |
5 |
107,257,550 (GRCm39) |
missense |
unknown |
|
|
R9784:Tgfbr3
|
UTSW |
5 |
107,297,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0022:Tgfbr3
|
UTSW |
5 |
107,284,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTCTTAAGACACAGCAAGGCAG -3'
(R):5'- GTGTTCATAGGTCCAGAGCC -3'
Sequencing Primer
(F):5'- CAGGAGGAAAGAAGGGAAATGTGATC -3'
(R):5'- TAGGTCCAGAGCCCAGCAC -3'
|
| Posted On |
2015-04-17 |
Incidental Mutation