Incidental Mutation 'R3898:Vmn2r12'
ID 309047
Institutional Source Beutler Lab
Gene Symbol Vmn2r12
Ensembl Gene ENSMUSG00000090688
Gene Name vomeronasal 2, receptor 12
Synonyms Gm6769
MMRRC Submission 040906-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R3898 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 109233715-109245730 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 109238370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 457 (A457T)
Ref Sequence ENSEMBL: ENSMUSP00000093612 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095922]
AlphaFold L7N217
Predicted Effect probably benign
Transcript: ENSMUST00000095922
AA Change: A457T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000093612
Gene: ENSMUSG00000090688
AA Change: A457T

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 76 466 8.8e-30 PFAM
Pfam:NCD3G 505 559 1.7e-18 PFAM
Pfam:7tm_3 591 827 3.9e-54 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg1 A C 16: 5,054,253 (GRCm39) I154L possibly damaging Het
Ankra2 C T 13: 98,410,317 (GRCm39) L136F probably benign Het
Anpep A G 7: 79,488,973 (GRCm39) S372P probably benign Het
Cabyr T C 18: 12,884,580 (GRCm39) S356P probably benign Het
Cad G T 5: 31,231,366 (GRCm39) C1633F probably benign Het
Cadps2 G A 6: 23,528,125 (GRCm39) R425W probably damaging Het
Ccdc180 A G 4: 45,912,799 (GRCm39) K593E possibly damaging Het
Cdh8 T A 8: 99,898,005 (GRCm39) E436V probably damaging Het
Cfap95 A G 19: 23,570,466 (GRCm39) V101A probably benign Het
Cln6 T G 9: 62,757,934 (GRCm39) F231C probably damaging Het
Cul2 A G 18: 3,434,033 (GRCm39) K677E probably benign Het
Cyp2c69 T C 19: 39,864,834 (GRCm39) I215V probably benign Het
Dhx36 T C 3: 62,399,790 (GRCm39) D393G probably damaging Het
Dnah7b T C 1: 46,282,417 (GRCm39) V2850A probably damaging Het
Dnah8 G A 17: 31,073,872 (GRCm39) R4514H probably damaging Het
Drg2 T A 11: 60,347,460 (GRCm39) S50T probably benign Het
Ecscr A G 18: 35,846,705 (GRCm39) S230P possibly damaging Het
Eif2ak4 T C 2: 118,261,404 (GRCm39) V527A probably damaging Het
Elfn1 G A 5: 139,957,719 (GRCm39) R241H probably damaging Het
Fchsd2 A G 7: 100,841,006 (GRCm39) K172E possibly damaging Het
Fli1 C T 9: 32,388,018 (GRCm39) G24R possibly damaging Het
Frmd3 A G 4: 73,992,346 (GRCm39) D71G probably damaging Het
Ggnbp1 A G 17: 27,244,312 (GRCm39) probably benign Het
Gpat2 T C 2: 127,277,018 (GRCm39) F713S probably damaging Het
H2-Q2 C T 17: 35,561,743 (GRCm39) P78S probably damaging Het
Kcnq2 C T 2: 180,751,479 (GRCm39) A306T probably damaging Het
Lmntd1 G A 6: 145,359,152 (GRCm39) P333S probably benign Het
Lrp1 G A 10: 127,427,969 (GRCm39) R535* probably null Het
Mmrn2 G T 14: 34,121,517 (GRCm39) probably null Het
Nlrp1a G A 11: 71,013,700 (GRCm39) P517S probably benign Het
Or2y13 A T 11: 49,415,386 (GRCm39) I279F probably damaging Het
Pou4f1 T C 14: 104,703,165 (GRCm39) *422W probably null Het
Ptpn14 C T 1: 189,582,728 (GRCm39) P525L probably benign Het
Pyroxd2 C A 19: 42,728,831 (GRCm39) G190C probably damaging Het
Rd3 T C 1: 191,717,217 (GRCm39) V114A probably damaging Het
Sptbn5 T C 2: 119,887,691 (GRCm39) noncoding transcript Het
Tbc1d5 A T 17: 51,270,772 (GRCm39) F153Y probably damaging Het
Thop1 G A 10: 80,916,278 (GRCm39) G429S probably damaging Het
Trim30d T A 7: 104,132,736 (GRCm39) I184L probably benign Het
Ubr5 T C 15: 37,997,983 (GRCm39) S1727G probably benign Het
Vezf1 T C 11: 87,966,999 (GRCm39) F77L probably benign Het
Xirp1 A T 9: 119,848,406 (GRCm39) M159K probably benign Het
Zkscan17 C T 11: 59,394,263 (GRCm39) A113T probably damaging Het
Zyg11a T A 4: 108,067,391 (GRCm39) N40Y probably damaging Het
Other mutations in Vmn2r12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Vmn2r12 APN 5 109,245,541 (GRCm39) missense possibly damaging 0.47
IGL01096:Vmn2r12 APN 5 109,234,125 (GRCm39) missense probably damaging 1.00
IGL01538:Vmn2r12 APN 5 109,239,716 (GRCm39) missense probably damaging 1.00
IGL01548:Vmn2r12 APN 5 109,240,893 (GRCm39) nonsense probably null
IGL01762:Vmn2r12 APN 5 109,234,430 (GRCm39) missense probably damaging 0.99
IGL01860:Vmn2r12 APN 5 109,240,025 (GRCm39) missense probably benign 0.10
IGL02269:Vmn2r12 APN 5 109,234,343 (GRCm39) missense probably damaging 1.00
IGL02530:Vmn2r12 APN 5 109,233,858 (GRCm39) missense probably damaging 1.00
IGL02887:Vmn2r12 APN 5 109,238,351 (GRCm39) missense probably benign 0.03
IGL03265:Vmn2r12 APN 5 109,239,936 (GRCm39) missense probably benign 0.05
R0396:Vmn2r12 UTSW 5 109,240,765 (GRCm39) missense probably benign 0.00
R0497:Vmn2r12 UTSW 5 109,239,755 (GRCm39) nonsense probably null
R0529:Vmn2r12 UTSW 5 109,240,714 (GRCm39) missense probably benign
R0715:Vmn2r12 UTSW 5 109,238,373 (GRCm39) missense probably benign 0.10
R0742:Vmn2r12 UTSW 5 109,234,281 (GRCm39) missense possibly damaging 0.55
R0894:Vmn2r12 UTSW 5 109,235,716 (GRCm39) critical splice donor site probably null
R1173:Vmn2r12 UTSW 5 109,240,720 (GRCm39) missense probably benign 0.00
R1174:Vmn2r12 UTSW 5 109,240,720 (GRCm39) missense probably benign 0.00
R1259:Vmn2r12 UTSW 5 109,239,763 (GRCm39) missense probably damaging 0.97
R1349:Vmn2r12 UTSW 5 109,234,452 (GRCm39) missense probably benign 0.00
R1388:Vmn2r12 UTSW 5 109,240,840 (GRCm39) missense possibly damaging 0.56
R1549:Vmn2r12 UTSW 5 109,240,696 (GRCm39) missense probably benign 0.06
R1766:Vmn2r12 UTSW 5 109,239,910 (GRCm39) missense probably damaging 1.00
R1781:Vmn2r12 UTSW 5 109,239,594 (GRCm39) missense probably benign 0.00
R1885:Vmn2r12 UTSW 5 109,239,942 (GRCm39) missense probably damaging 1.00
R2159:Vmn2r12 UTSW 5 109,239,340 (GRCm39) missense probably benign 0.02
R2420:Vmn2r12 UTSW 5 109,234,398 (GRCm39) missense probably benign 0.39
R2421:Vmn2r12 UTSW 5 109,234,398 (GRCm39) missense probably benign 0.39
R2422:Vmn2r12 UTSW 5 109,234,398 (GRCm39) missense probably benign 0.39
R2937:Vmn2r12 UTSW 5 109,239,397 (GRCm39) missense probably damaging 1.00
R2938:Vmn2r12 UTSW 5 109,239,397 (GRCm39) missense probably damaging 1.00
R4061:Vmn2r12 UTSW 5 109,240,058 (GRCm39) missense possibly damaging 0.95
R4063:Vmn2r12 UTSW 5 109,240,058 (GRCm39) missense possibly damaging 0.95
R4090:Vmn2r12 UTSW 5 109,239,412 (GRCm39) missense probably benign 0.06
R4297:Vmn2r12 UTSW 5 109,239,830 (GRCm39) missense probably benign 0.12
R4298:Vmn2r12 UTSW 5 109,239,830 (GRCm39) missense probably benign 0.12
R4299:Vmn2r12 UTSW 5 109,239,830 (GRCm39) missense probably benign 0.12
R4304:Vmn2r12 UTSW 5 109,233,872 (GRCm39) missense probably damaging 1.00
R4306:Vmn2r12 UTSW 5 109,233,872 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r12 UTSW 5 109,233,872 (GRCm39) missense probably damaging 1.00
R4308:Vmn2r12 UTSW 5 109,233,872 (GRCm39) missense probably damaging 1.00
R4594:Vmn2r12 UTSW 5 109,234,301 (GRCm39) missense probably damaging 1.00
R4783:Vmn2r12 UTSW 5 109,234,379 (GRCm39) missense probably damaging 1.00
R4900:Vmn2r12 UTSW 5 109,240,852 (GRCm39) missense probably damaging 1.00
R4929:Vmn2r12 UTSW 5 109,239,544 (GRCm39) missense probably damaging 1.00
R4974:Vmn2r12 UTSW 5 109,239,372 (GRCm39) missense probably damaging 1.00
R5389:Vmn2r12 UTSW 5 109,238,261 (GRCm39) missense probably benign 0.00
R5431:Vmn2r12 UTSW 5 109,239,684 (GRCm39) missense probably damaging 0.99
R5527:Vmn2r12 UTSW 5 109,234,483 (GRCm39) nonsense probably null
R5639:Vmn2r12 UTSW 5 109,240,666 (GRCm39) missense probably benign 0.06
R5753:Vmn2r12 UTSW 5 109,239,670 (GRCm39) missense probably damaging 1.00
R5797:Vmn2r12 UTSW 5 109,233,736 (GRCm39) nonsense probably null
R6142:Vmn2r12 UTSW 5 109,240,763 (GRCm39) missense probably benign
R6162:Vmn2r12 UTSW 5 109,234,430 (GRCm39) missense probably damaging 0.99
R6176:Vmn2r12 UTSW 5 109,233,866 (GRCm39) missense probably benign 0.43
R6853:Vmn2r12 UTSW 5 109,240,771 (GRCm39) missense probably damaging 1.00
R7238:Vmn2r12 UTSW 5 109,245,655 (GRCm39) missense possibly damaging 0.81
R7341:Vmn2r12 UTSW 5 109,239,811 (GRCm39) missense possibly damaging 0.95
R7341:Vmn2r12 UTSW 5 109,234,113 (GRCm39) missense possibly damaging 0.74
R7383:Vmn2r12 UTSW 5 109,240,684 (GRCm39) missense probably benign 0.19
R7740:Vmn2r12 UTSW 5 109,239,615 (GRCm39) missense probably damaging 1.00
R7749:Vmn2r12 UTSW 5 109,233,920 (GRCm39) missense probably damaging 0.99
R7861:Vmn2r12 UTSW 5 109,235,829 (GRCm39) missense probably benign 0.00
R7908:Vmn2r12 UTSW 5 109,234,307 (GRCm39) missense probably damaging 1.00
R8128:Vmn2r12 UTSW 5 109,239,747 (GRCm39) missense possibly damaging 0.81
R8175:Vmn2r12 UTSW 5 109,238,349 (GRCm39) missense probably damaging 0.97
R8234:Vmn2r12 UTSW 5 109,234,074 (GRCm39) missense probably benign 0.01
R8771:Vmn2r12 UTSW 5 109,239,952 (GRCm39) missense possibly damaging 0.95
R8947:Vmn2r12 UTSW 5 109,234,522 (GRCm39) missense possibly damaging 0.64
R8991:Vmn2r12 UTSW 5 109,234,033 (GRCm39) nonsense probably null
R9116:Vmn2r12 UTSW 5 109,233,885 (GRCm39) missense probably damaging 1.00
R9122:Vmn2r12 UTSW 5 109,240,910 (GRCm39) missense probably benign 0.00
R9153:Vmn2r12 UTSW 5 109,234,203 (GRCm39) missense probably damaging 1.00
R9371:Vmn2r12 UTSW 5 109,234,452 (GRCm39) missense probably benign 0.00
R9375:Vmn2r12 UTSW 5 109,233,986 (GRCm39) missense probably damaging 1.00
R9524:Vmn2r12 UTSW 5 109,239,823 (GRCm39) missense probably damaging 1.00
R9587:Vmn2r12 UTSW 5 109,239,322 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r12 UTSW 5 109,240,646 (GRCm39) missense probably benign
Z1176:Vmn2r12 UTSW 5 109,239,303 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCTGTAAGTATAGTCACAAGGAATC -3'
(R):5'- TTCTAGCACATTCTACCATGGAC -3'

Sequencing Primer
(F):5'- GGTCTTTGCTCCATATAACCAGAAGG -3'
(R):5'- CAGCTGTCTTTCTGAAATTCATTAAG -3'
Posted On 2015-04-17