Incidental Mutation 'R3906:Or11g27'
ID 309199
Institutional Source Beutler Lab
Gene Symbol Or11g27
Ensembl Gene ENSMUSG00000094285
Gene Name olfactory receptor family 11 subfamily G member 27
Synonyms GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, Olfr264, Olfr743, Olfr743-ps1, Olfr265, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2N6FY-3870-3385, MOR106-14
MMRRC Submission 040813-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R3906 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50770871-50771806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 50771211 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 114 (T114I)
Ref Sequence ENSEMBL: ENSMUSP00000150946 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071294] [ENSMUST00000215793]
AlphaFold L7N1Y2
Predicted Effect probably benign
Transcript: ENSMUST00000071294
AA Change: T114I

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000071263
Gene: ENSMUSG00000094285
AA Change: T114I

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.6e-56 PFAM
Pfam:7tm_1 45 294 1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215793
AA Change: T114I

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.3994 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 97% (36/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A G 4: 53,067,151 (GRCm39) V1352A possibly damaging Het
Abcb7 G T X: 103,327,765 (GRCm39) Q715K probably benign Het
Adamts3 C A 5: 90,009,214 (GRCm39) G150C probably damaging Het
Ank2 A G 3: 126,810,547 (GRCm39) L513P probably damaging Het
Cacng1 C A 11: 107,607,118 (GRCm39) V34L probably benign Het
Cd1d1 A G 3: 86,906,063 (GRCm39) W71R probably damaging Het
Cdhr3 A G 12: 33,103,427 (GRCm39) F397L probably damaging Het
Ces2a A G 8: 105,465,940 (GRCm39) I325V probably benign Het
Ctsq C T 13: 61,186,585 (GRCm39) V140M probably damaging Het
Cyp4f18 A G 8: 72,754,926 (GRCm39) probably benign Het
Ddi2 T C 4: 141,411,592 (GRCm39) D440G probably benign Het
Dsg3 G A 18: 20,671,556 (GRCm39) G754R probably damaging Het
Endod1 T A 9: 14,292,151 (GRCm39) Y39F probably benign Het
F11 A G 8: 45,701,675 (GRCm39) S353P probably damaging Het
Fn1 C T 1: 71,647,072 (GRCm39) G1482R probably damaging Het
Fpr2 A G 17: 18,113,811 (GRCm39) K269R probably benign Het
Frk T G 10: 34,460,052 (GRCm39) L216V probably benign Het
Gan G A 8: 117,920,873 (GRCm39) V370M probably damaging Het
Grik1 A G 16: 87,803,337 (GRCm39) I285T probably benign Het
Hspa1a C T 17: 35,190,703 (GRCm39) V67M probably damaging Het
Kbtbd8 T A 6: 95,103,565 (GRCm39) Y405N probably damaging Het
Kcnj4 G T 15: 79,369,946 (GRCm39) H11Q probably benign Het
Kif26a T A 12: 112,143,324 (GRCm39) S1193T probably benign Het
Kmt2e A G 5: 23,706,624 (GRCm39) N1396D probably benign Het
Lasp1 G A 11: 97,690,653 (GRCm39) V12M probably damaging Het
Lrrk1 G T 7: 65,944,651 (GRCm39) T653K possibly damaging Het
Meiob A G 17: 25,046,922 (GRCm39) Y182C probably benign Het
Myh6 T C 14: 55,194,412 (GRCm39) D739G probably benign Het
Ninl T C 2: 150,822,039 (GRCm39) D21G probably damaging Het
Or9i16 C T 19: 13,865,070 (GRCm39) C168Y probably damaging Het
Pacsin2 A C 15: 83,263,256 (GRCm39) V125G probably damaging Het
Pfas G A 11: 68,879,112 (GRCm39) probably benign Het
Pla2g4f C T 2: 120,130,980 (GRCm39) R825Q probably benign Het
Prkd1 A T 12: 50,435,209 (GRCm39) V506E possibly damaging Het
Psmd2 A G 16: 20,474,392 (GRCm39) D316G probably benign Het
Ryr2 T A 13: 11,753,095 (GRCm39) D1742V possibly damaging Het
Szt2 G A 4: 118,235,466 (GRCm39) probably benign Het
Ugt8a T C 3: 125,708,631 (GRCm39) T160A possibly damaging Het
Xrcc6 A G 15: 81,913,772 (GRCm39) T378A probably benign Het
Other mutations in Or11g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01128:Or11g27 APN 14 50,771,406 (GRCm39) missense probably damaging 1.00
IGL01551:Or11g27 APN 14 50,771,618 (GRCm39) missense probably benign
IGL02024:Or11g27 APN 14 50,771,307 (GRCm39) missense probably benign 0.00
IGL02867:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL02889:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL03195:Or11g27 APN 14 50,770,877 (GRCm39) missense probably benign
IGL03296:Or11g27 APN 14 50,771,402 (GRCm39) missense possibly damaging 0.90
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0102:Or11g27 UTSW 14 50,771,088 (GRCm39) missense probably damaging 1.00
R0556:Or11g27 UTSW 14 50,771,381 (GRCm39) missense probably benign 0.01
R0626:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0661:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
R0759:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0761:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0894:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1109:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1110:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1312:Or11g27 UTSW 14 50,771,652 (GRCm39) missense probably benign
R1446:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1502:Or11g27 UTSW 14 50,771,234 (GRCm39) missense possibly damaging 0.47
R1518:Or11g27 UTSW 14 50,771,622 (GRCm39) missense probably damaging 1.00
R1529:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1624:Or11g27 UTSW 14 50,771,100 (GRCm39) missense probably damaging 1.00
R1646:Or11g27 UTSW 14 50,771,040 (GRCm39) missense probably benign 0.01
R1687:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1795:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R2011:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 1.00
R2120:Or11g27 UTSW 14 50,771,403 (GRCm39) missense probably damaging 1.00
R2697:Or11g27 UTSW 14 50,771,238 (GRCm39) missense probably damaging 1.00
R2857:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R2858:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R4327:Or11g27 UTSW 14 50,770,971 (GRCm39) missense probably benign 0.05
R4355:Or11g27 UTSW 14 50,771,216 (GRCm39) missense possibly damaging 0.94
R4663:Or11g27 UTSW 14 50,771,061 (GRCm39) missense probably damaging 1.00
R5214:Or11g27 UTSW 14 50,771,804 (GRCm39) makesense probably null
R5964:Or11g27 UTSW 14 50,771,655 (GRCm39) missense probably damaging 0.99
R6148:Or11g27 UTSW 14 50,771,778 (GRCm39) missense probably benign 0.00
R6167:Or11g27 UTSW 14 50,771,612 (GRCm39) missense probably damaging 1.00
R6301:Or11g27 UTSW 14 50,771,711 (GRCm39) missense probably benign 0.02
R6616:Or11g27 UTSW 14 50,771,364 (GRCm39) missense probably benign 0.43
R6910:Or11g27 UTSW 14 50,771,330 (GRCm39) missense probably benign 0.31
R7076:Or11g27 UTSW 14 50,771,278 (GRCm39) nonsense probably null
R7483:Or11g27 UTSW 14 50,771,472 (GRCm39) missense probably benign 0.06
R7574:Or11g27 UTSW 14 50,771,770 (GRCm39) missense probably benign 0.01
R7731:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 0.99
R8691:Or11g27 UTSW 14 50,770,910 (GRCm39) missense probably benign 0.01
R9072:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9073:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9321:Or11g27 UTSW 14 50,771,471 (GRCm39) missense probably benign 0.01
R9478:Or11g27 UTSW 14 50,771,051 (GRCm39) missense probably benign 0.01
R9557:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTGTGATCAGAGACTCCACACC -3'
(R):5'- AAAGAGGACCTGGGTCACAC -3'

Sequencing Primer
(F):5'- ACACCCCCATGTACCTCCTG -3'
(R):5'- GTGGTCTATAATTCTGGACCCACAG -3'
Posted On 2015-04-17