Incidental Mutation 'R3903:Eif4a2'
ID 309280
Institutional Source Beutler Lab
Gene Symbol Eif4a2
Ensembl Gene ENSMUSG00000022884
Gene Name eukaryotic translation initiation factor 4A2
Synonyms 4833432N07Rik, Ddx2b, Eif4, BM-010
MMRRC Submission 040907-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.580) question?
Stock # R3903 (G1)
Quality Score 217
Status Validated
Chromosome 16
Chromosomal Location 22926194-22932886 bp(+) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) AG to A at 22929390 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000156170 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023598] [ENSMUST00000023599] [ENSMUST00000077605] [ENSMUST00000115341] [ENSMUST00000123413] [ENSMUST00000131871] [ENSMUST00000115338] [ENSMUST00000133847] [ENSMUST00000168891] [ENSMUST00000187168] [ENSMUST00000147117] [ENSMUST00000232287]
AlphaFold P10630
Predicted Effect probably benign
Transcript: ENSMUST00000023598
SMART Domains Protein: ENSMUSP00000023598
Gene: ENSMUSG00000022881

DomainStartEndE-ValueType
AAA 70 202 5.8e-13 SMART
Pfam:Rep_fac_C 267 356 2.2e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000023599
SMART Domains Protein: ENSMUSP00000023599
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
DEXDc 52 250 4.62e-58 SMART
HELICc 287 368 5.21e-34 SMART
Predicted Effect probably null
Transcript: ENSMUST00000077605
SMART Domains Protein: ENSMUSP00000090876
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
DEXDc 52 250 4.62e-58 SMART
HELICc 287 362 1.86e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082448
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082946
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083274
Predicted Effect probably null
Transcript: ENSMUST00000115341
AA Change: 230
SMART Domains Protein: ENSMUSP00000110998
Gene: ENSMUSG00000022884
AA Change: 230

DomainStartEndE-ValueType
DEXDc 53 251 4.62e-58 SMART
HELICc 288 369 5.21e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125969
Predicted Effect probably null
Transcript: ENSMUST00000123413
SMART Domains Protein: ENSMUSP00000115649
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
DEXDc 52 250 4.62e-58 SMART
HELICc 287 362 1.86e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130113
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125553
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135020
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134816
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130483
Predicted Effect probably benign
Transcript: ENSMUST00000131871
SMART Domains Protein: ENSMUSP00000118141
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
PDB:3EIQ|D 4 70 2e-33 PDB
Blast:DEXDc 17 73 3e-25 BLAST
SCOP:d1qdea_ 25 71 2e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115338
SMART Domains Protein: ENSMUSP00000110995
Gene: ENSMUSG00000022881

DomainStartEndE-ValueType
AAA 70 202 5.8e-13 SMART
Pfam:Rep_fac_C 269 344 3.5e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000133847
SMART Domains Protein: ENSMUSP00000115479
Gene: ENSMUSG00000022881

DomainStartEndE-ValueType
Pfam:Rad17 32 97 3.7e-9 PFAM
Pfam:AAA 74 98 2.4e-6 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000168891
SMART Domains Protein: ENSMUSP00000127030
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
DEXDc 1 155 1.92e-14 SMART
HELICc 192 273 5.21e-34 SMART
Predicted Effect probably null
Transcript: ENSMUST00000187168
SMART Domains Protein: ENSMUSP00000140809
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
DEXDc 52 250 4.62e-58 SMART
HELICc 287 362 1.86e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157310
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140017
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156227
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150117
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149328
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148085
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147321
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157899
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141392
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152129
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197708
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144493
Predicted Effect probably benign
Transcript: ENSMUST00000147117
SMART Domains Protein: ENSMUSP00000121745
Gene: ENSMUSG00000022884

DomainStartEndE-ValueType
PDB:3EIQ|D 4 69 4e-33 PDB
Blast:DEXDc 16 72 3e-25 BLAST
SCOP:d1qdea_ 24 70 2e-14 SMART
Predicted Effect probably null
Transcript: ENSMUST00000232287
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amd1 C T 10: 40,166,453 (GRCm39) R210H probably benign Het
Amt C T 9: 108,174,420 (GRCm39) R62C possibly damaging Het
Ap3m1 T C 14: 21,086,732 (GRCm39) Y185C probably null Het
Calcrl T A 2: 84,198,986 (GRCm39) probably benign Het
Ccdc178 C T 18: 22,156,152 (GRCm39) V573I possibly damaging Het
Cdh6 T C 15: 13,042,661 (GRCm39) K499R probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Col6a1 C T 10: 76,547,175 (GRCm39) R730H unknown Het
Cyp4f40 C A 17: 32,878,598 (GRCm39) R47S possibly damaging Het
Fsip2l T C X: 47,930,421 (GRCm39) N649S possibly damaging Het
Gm8180 T A 14: 44,021,092 (GRCm39) R39W probably null Het
Golm1 T C 13: 59,786,154 (GRCm39) Q346R probably damaging Het
Grap T G 11: 61,551,151 (GRCm39) probably null Het
Hormad2 A G 11: 4,377,237 (GRCm39) probably benign Het
Hyal1 T C 9: 107,456,171 (GRCm39) probably null Het
Kif12 A G 4: 63,086,213 (GRCm39) V378A possibly damaging Het
Lrrk2 G A 15: 91,631,904 (GRCm39) S1276N probably damaging Het
Lrrk2 A T 15: 91,631,903 (GRCm39) S1276C probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or4f53 A T 2: 111,088,114 (GRCm39) Y218F probably damaging Het
Or7c70 T G 10: 78,683,132 (GRCm39) I206L probably benign Het
Or8c20 C T 9: 38,260,954 (GRCm39) Q186* probably null Het
Pabpc6 T C 17: 9,888,083 (GRCm39) E156G probably benign Het
Rorb A G 19: 18,939,463 (GRCm39) Y155H probably damaging Het
Samd9l T A 6: 3,376,830 (GRCm39) K144* probably null Het
Scn1a A G 2: 66,148,476 (GRCm39) I3T probably benign Het
Serpinb9 T C 13: 33,194,793 (GRCm39) M183T possibly damaging Het
Wnk1 A G 6: 119,926,012 (GRCm39) S1151P probably damaging Het
Xirp2 C T 2: 67,338,380 (GRCm39) T207I probably benign Het
Zfp39 T C 11: 58,781,001 (GRCm39) Y587C probably benign Het
Other mutations in Eif4a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01680:Eif4a2 APN 16 22,927,941 (GRCm39) missense probably benign 0.05
IGL02426:Eif4a2 APN 16 22,929,399 (GRCm39) missense probably benign 0.00
unflappable UTSW 16 22,929,390 (GRCm39) frame shift probably null
R4880:Eif4a2 UTSW 16 22,927,650 (GRCm39) intron probably benign
R5623:Eif4a2 UTSW 16 22,928,969 (GRCm39) splice site probably benign
R7350:Eif4a2 UTSW 16 22,932,012 (GRCm39) missense possibly damaging 0.95
R7574:Eif4a2 UTSW 16 22,928,877 (GRCm39) missense probably benign 0.45
R8290:Eif4a2 UTSW 16 22,927,372 (GRCm39) missense probably damaging 1.00
R9072:Eif4a2 UTSW 16 22,929,403 (GRCm39) missense probably benign 0.00
R9073:Eif4a2 UTSW 16 22,929,403 (GRCm39) missense probably benign 0.00
RF006:Eif4a2 UTSW 16 22,929,028 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- CCATACTAAGGCAGAGACGC -3'
(R):5'- CCCAGTCTTTGCAATCCAGTG -3'

Sequencing Primer
(F):5'- CAGAGACGCTTGGTTTCAAAC -3'
(R):5'- ACCTCTCGCTCAACATTAA -3'
Posted On 2015-04-17