Mutagenetix > Incidental Mutation

Incidental Mutation 'R3910:Zfp119a'

309356

Institutional Source

Beutler Lab

Gene Symbol

Zfp119a

Ensembl Gene

ENSMUSG00000057835

Gene Name

zinc finger protein 119a

Synonyms

Mzf13, Zfp119

MMRRC Submission

040815-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R3910 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

56171892-56185930 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 56173520 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 108 (L108F)

Ref Sequence

ENSEMBL: ENSMUSP00000078587 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079642]

AlphaFold

Q9JIC0

Predicted Effect

probably benign
Transcript: ENSMUST00000079642
AA Change: L108F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000078587
Gene: ENSMUSG00000057835
AA Change: L108F

Domain	Start	End	E-Value	Type
KRAB	4	66	6.16e-15	SMART
ZnF_C2H2	155	177	1.57e2	SMART
ZnF_C2H2	261	283	2.14e2	SMART
ZnF_C2H2	289	311	6.78e-3	SMART
ZnF_C2H2	317	339	1.98e-4	SMART
ZnF_C2H2	345	367	4.17e-3	SMART
ZnF_C2H2	373	395	3.39e-3	SMART
ZnF_C2H2	401	423	1.64e-1	SMART
ZnF_C2H2	429	451	5.5e-3	SMART
ZnF_C2H2	457	479	1.51e0	SMART
ZnF_C2H2	485	507	6.32e-3	SMART
ZnF_C2H2	513	535	1.69e-3	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.4%
20x: 95.5%

Validation Efficiency

97% (36/37)

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bod1l	T	C	5: 41,974,441 (GRCm39)	E2291G	probably damaging	Het
Cchcr1	T	C	17: 35,836,233 (GRCm39)	V341A	probably damaging	Het
Cimip3	AC	A	17: 47,744,348 (GRCm39)		probably benign	Het
Dsg1c	T	C	18: 20,399,253 (GRCm39)	V119A	possibly damaging	Het
Fap	A	G	2: 62,386,448 (GRCm39)	S58P	probably damaging	Het
Flnc	A	T	6: 29,459,426 (GRCm39)	T2509S	probably damaging	Het
Fnip2	A	T	3: 79,386,812 (GRCm39)	D971E	possibly damaging	Het
Gab2	A	G	7: 96,948,280 (GRCm39)	Y290C	probably damaging	Het
Gm7104	C	T	12: 88,251,364 (GRCm39)		noncoding transcript	Het
Ints10	T	A	8: 69,266,272 (GRCm39)	S478T	probably damaging	Het
Iqca1l	A	T	5: 24,750,440 (GRCm39)		probably benign	Het
Kirrel1	C	T	3: 86,996,458 (GRCm39)	M380I	probably null	Het
Krt90	G	A	15: 101,471,218 (GRCm39)	R15W	probably damaging	Het
Lgr5	A	G	10: 115,423,368 (GRCm39)	S11P	possibly damaging	Het
Mycn	T	A	12: 12,987,281 (GRCm39)	N372I	probably damaging	Het
Or2ag18	A	T	7: 106,405,072 (GRCm39)	V199D	probably damaging	Het
Or9a2	A	G	6: 41,749,083 (GRCm39)	V50A	probably benign	Het
Paxbp1	T	A	16: 90,839,569 (GRCm39)	E117V	probably damaging	Het
Phc2	T	C	4: 128,637,351 (GRCm39)		probably null	Het
Prr5	T	A	15: 84,587,345 (GRCm39)	V365E	probably benign	Het
Rev3l	A	G	10: 39,696,552 (GRCm39)	I521M	probably damaging	Het
Robo3	A	T	9: 37,330,591 (GRCm39)	Y1002N	probably damaging	Het
Svep1	A	T	4: 58,145,156 (GRCm39)		probably null	Het
Thsd7a	A	G	6: 12,331,548 (GRCm39)	V1342A	probably damaging	Het
Tmtc3	A	C	10: 100,284,888 (GRCm39)	N582K	probably damaging	Het
Tnfrsf11b	G	A	15: 54,119,578 (GRCm39)		probably benign	Het
Trim30a	A	G	7: 104,060,348 (GRCm39)	V476A	probably damaging	Het
Ugt1a8	A	G	1: 88,015,770 (GRCm39)	E61G	possibly damaging	Het
Vmn1r75	A	T	7: 11,614,757 (GRCm39)	N163I	possibly damaging	Het
Vps35l	A	G	7: 118,345,613 (GRCm39)	T49A	possibly damaging	Het

Other mutations in Zfp119a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Zfp119a	APN	17	56,172,792 (GRCm39)	nonsense	probably null
R0421:Zfp119a	UTSW	17	56,172,248 (GRCm39)	nonsense	probably null
R1385:Zfp119a	UTSW	17	56,172,826 (GRCm39)	missense	probably damaging	1.00
R1600:Zfp119a	UTSW	17	56,175,355 (GRCm39)	missense	possibly damaging	0.93
R2310:Zfp119a	UTSW	17	56,172,440 (GRCm39)	missense	probably benign	0.00
R2924:Zfp119a	UTSW	17	56,175,343 (GRCm39)	missense	possibly damaging	0.96
R4594:Zfp119a	UTSW	17	56,173,325 (GRCm39)	missense	probably benign
R5217:Zfp119a	UTSW	17	56,172,425 (GRCm39)	nonsense	probably null
R5321:Zfp119a	UTSW	17	56,172,595 (GRCm39)	missense	probably damaging	1.00
R5392:Zfp119a	UTSW	17	56,173,328 (GRCm39)	missense	probably benign	0.03
R5678:Zfp119a	UTSW	17	56,175,336 (GRCm39)	missense	probably benign	0.03
R7033:Zfp119a	UTSW	17	56,173,009 (GRCm39)	missense	probably benign	0.04
R7355:Zfp119a	UTSW	17	56,173,287 (GRCm39)	nonsense	probably null
R7489:Zfp119a	UTSW	17	56,173,158 (GRCm39)	missense	probably damaging	1.00
R8130:Zfp119a	UTSW	17	56,172,971 (GRCm39)	missense	probably damaging	1.00
R8940:Zfp119a	UTSW	17	56,172,551 (GRCm39)	missense	probably damaging	1.00
R9542:Zfp119a	UTSW	17	56,172,593 (GRCm39)	nonsense	probably null
Z1176:Zfp119a	UTSW	17	56,173,011 (GRCm39)	missense	possibly damaging	0.61

Predicted Primers

PCR Primer
(F):5'- AACAGGAAGAACTCAGAGCTTTA -3'
(R):5'- GGCGGCTGGGAATCCTAAA -3'

Sequencing Primer
(F):5'- AGAGCTTTACCACACTGATTGC -3'
(R):5'- GCTGGGAATCCTAAAGTACTGCCTC -3'

Posted On

2015-04-17