Incidental Mutation 'R3912:Myrip'
ID 309468
Institutional Source Beutler Lab
Gene Symbol Myrip
Ensembl Gene ENSMUSG00000041794
Gene Name myosin VIIA and Rab interacting protein
Synonyms A230081N12Rik, Slac2-c
MMRRC Submission 040910-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3912 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 120132996-120305167 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 120261682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 432 (S432G)
Ref Sequence ENSEMBL: ENSMUSP00000046891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048121]
AlphaFold Q8K3I4
Predicted Effect probably benign
Transcript: ENSMUST00000048121
AA Change: S432G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000046891
Gene: ENSMUSG00000041794
AA Change: S432G

DomainStartEndE-ValueType
Pfam:FYVE_2 8 125 3.8e-46 PFAM
Pfam:Rab_eff_C 152 856 N/A PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129168
Predicted Effect unknown
Transcript: ENSMUST00000214784
AA Change: S427G
Meta Mutation Damage Score 0.0636 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot1 A G 12: 84,063,806 (GRCm39) S305G probably damaging Het
Acot12 A G 13: 91,918,208 (GRCm39) D167G probably benign Het
Adgra1 T C 7: 139,425,630 (GRCm39) probably null Het
Adh7 T A 3: 137,927,541 (GRCm39) V29E probably damaging Het
Aopep G T 13: 63,304,520 (GRCm39) E402* probably null Het
Atp2c2 A G 8: 120,448,015 (GRCm39) K103E probably damaging Het
Camkk1 A G 11: 72,924,642 (GRCm39) D285G probably benign Het
Ccdc158 G C 5: 92,796,794 (GRCm39) T514S possibly damaging Het
Cdhr5 T A 7: 140,853,770 (GRCm39) D210V probably damaging Het
Cndp1 C T 18: 84,650,124 (GRCm39) D190N probably benign Het
Eepd1 C T 9: 25,394,600 (GRCm39) T288M probably damaging Het
Erbin G T 13: 103,998,795 (GRCm39) T197K probably benign Het
Erbin G A 13: 104,022,846 (GRCm39) probably benign Het
Fnip2 A T 3: 79,386,812 (GRCm39) D971E possibly damaging Het
Gab2 A G 7: 96,948,280 (GRCm39) Y290C probably damaging Het
Gbp3 C T 3: 142,272,099 (GRCm39) probably benign Het
Gm14326 T C 2: 177,587,658 (GRCm39) K446R probably damaging Het
Herc2 T C 7: 55,748,185 (GRCm39) Y518H probably damaging Het
Id2 T A 12: 25,145,871 (GRCm39) K47* probably null Het
Ilf2 A G 3: 90,394,367 (GRCm39) N295S probably benign Het
Ilf3 C T 9: 21,309,422 (GRCm39) A526V possibly damaging Het
Ints10 T A 8: 69,266,272 (GRCm39) S478T probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lrrc7 G A 3: 157,997,589 (GRCm39) L158F probably damaging Het
Mroh9 C T 1: 162,893,638 (GRCm39) C179Y probably damaging Het
Mrps18b C T 17: 36,221,831 (GRCm39) V165I probably benign Het
Nutm2 C T 13: 50,626,976 (GRCm39) A377V possibly damaging Het
Or2ag18 A T 7: 106,405,072 (GRCm39) V199D probably damaging Het
Pate4 C A 9: 35,523,140 (GRCm39) M1I probably null Het
Pax7 C A 4: 139,508,209 (GRCm39) W272L probably benign Het
Ppp1r12b C T 1: 134,815,056 (GRCm39) E320K probably damaging Het
Prg4 T C 1: 150,327,619 (GRCm39) Y278C probably damaging Het
Pvr T C 7: 19,643,217 (GRCm39) N339D probably benign Het
Rev3l A G 10: 39,696,552 (GRCm39) I521M probably damaging Het
Ryr2 A G 13: 11,787,313 (GRCm39) I1020T probably damaging Het
Scn4a T A 11: 106,211,542 (GRCm39) I1492F probably damaging Het
Sec16a C T 2: 26,304,399 (GRCm39) G2304D probably damaging Het
Shisa7 T A 7: 4,833,239 (GRCm39) R341* probably null Het
Slc19a3 T A 1: 83,000,424 (GRCm39) M198L probably benign Het
Slc26a8 T A 17: 28,863,753 (GRCm39) N669Y possibly damaging Het
Slco1a7 A G 6: 141,673,362 (GRCm39) F392S probably damaging Het
Snap91 T C 9: 86,674,610 (GRCm39) T534A possibly damaging Het
Susd4 A T 1: 182,715,031 (GRCm39) Y284F probably damaging Het
Tas1r1 A T 4: 152,116,381 (GRCm39) Y418N probably damaging Het
Tdrd12 A G 7: 35,187,138 (GRCm39) I584T probably damaging Het
Tmtc3 A C 10: 100,284,888 (GRCm39) N582K probably damaging Het
Tnfrsf11b G A 15: 54,119,578 (GRCm39) probably benign Het
Trim30a A G 7: 104,060,348 (GRCm39) V476A probably damaging Het
Vmn1r39 C T 6: 66,782,125 (GRCm39) M27I probably benign Het
Vmn2r59 T C 7: 41,695,744 (GRCm39) T223A probably benign Het
Vps35l A G 7: 118,345,613 (GRCm39) T49A possibly damaging Het
Vwa5a T C 9: 38,646,039 (GRCm39) I469T probably damaging Het
Wnt3a A C 11: 59,140,828 (GRCm39) D229E possibly damaging Het
Other mutations in Myrip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01924:Myrip APN 9 120,217,330 (GRCm39) missense probably damaging 1.00
IGL02108:Myrip APN 9 120,296,631 (GRCm39) critical splice donor site probably null
IGL02406:Myrip APN 9 120,296,598 (GRCm39) missense probably benign
IGL02876:Myrip APN 9 120,261,740 (GRCm39) missense probably damaging 1.00
IGL03109:Myrip APN 9 120,282,790 (GRCm39) splice site probably null
IGL03258:Myrip APN 9 120,270,418 (GRCm39) missense probably benign 0.45
PIT4581001:Myrip UTSW 9 120,296,583 (GRCm39) missense probably damaging 0.98
R0485:Myrip UTSW 9 120,270,443 (GRCm39) missense probably benign 0.01
R0633:Myrip UTSW 9 120,217,302 (GRCm39) missense probably damaging 1.00
R1489:Myrip UTSW 9 120,261,595 (GRCm39) missense probably damaging 1.00
R1539:Myrip UTSW 9 120,253,689 (GRCm39) missense probably benign 0.00
R1708:Myrip UTSW 9 120,293,840 (GRCm39) missense possibly damaging 0.65
R1817:Myrip UTSW 9 120,217,228 (GRCm39) missense probably damaging 1.00
R1818:Myrip UTSW 9 120,217,228 (GRCm39) missense probably damaging 1.00
R1878:Myrip UTSW 9 120,253,721 (GRCm39) missense probably damaging 0.99
R2484:Myrip UTSW 9 120,253,685 (GRCm39) missense probably benign 0.00
R3237:Myrip UTSW 9 120,270,473 (GRCm39) missense possibly damaging 0.91
R3890:Myrip UTSW 9 120,251,324 (GRCm39) missense probably damaging 1.00
R3919:Myrip UTSW 9 120,261,695 (GRCm39) missense probably damaging 1.00
R4125:Myrip UTSW 9 120,293,764 (GRCm39) nonsense probably null
R4126:Myrip UTSW 9 120,293,764 (GRCm39) nonsense probably null
R4128:Myrip UTSW 9 120,293,764 (GRCm39) nonsense probably null
R4435:Myrip UTSW 9 120,164,680 (GRCm39) start gained probably benign
R4599:Myrip UTSW 9 120,293,850 (GRCm39) missense probably damaging 0.97
R5014:Myrip UTSW 9 120,251,534 (GRCm39) missense probably damaging 1.00
R5665:Myrip UTSW 9 120,290,499 (GRCm39) missense probably damaging 1.00
R5814:Myrip UTSW 9 120,253,734 (GRCm39) missense probably benign 0.06
R5849:Myrip UTSW 9 120,282,759 (GRCm39) missense probably damaging 0.99
R5986:Myrip UTSW 9 120,290,487 (GRCm39) missense probably damaging 1.00
R6706:Myrip UTSW 9 120,217,359 (GRCm39) missense possibly damaging 0.93
R7019:Myrip UTSW 9 120,251,573 (GRCm39) missense probably damaging 1.00
R7291:Myrip UTSW 9 120,246,207 (GRCm39) missense probably damaging 0.97
R8204:Myrip UTSW 9 120,262,045 (GRCm39) critical splice donor site probably null
R8557:Myrip UTSW 9 120,246,252 (GRCm39) missense probably benign 0.32
R8853:Myrip UTSW 9 120,290,487 (GRCm39) missense probably damaging 1.00
R8911:Myrip UTSW 9 120,270,484 (GRCm39) missense possibly damaging 0.94
R9106:Myrip UTSW 9 120,261,544 (GRCm39) missense probably benign 0.37
R9225:Myrip UTSW 9 120,293,850 (GRCm39) missense probably damaging 0.97
Z1177:Myrip UTSW 9 120,270,547 (GRCm39) missense probably damaging 1.00
Z1177:Myrip UTSW 9 120,261,844 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACCGAAGAGTGGGACCTTTC -3'
(R):5'- ACTGTCGGAAGTCTCTCCAC -3'

Sequencing Primer
(F):5'- AAGAGTGGGACCTTTCAGGCC -3'
(R):5'- GGTTGAAATTGACGTCCAGTTCTCC -3'
Posted On 2015-04-17