Incidental Mutation 'R3915:Or51a25'
ID 309595
Institutional Source Beutler Lab
Gene Symbol Or51a25
Ensembl Gene ENSMUSG00000066272
Gene Name olfactory receptor family 51 subfamily A member 25
Synonyms MOR11-1, Olfr559, GA_x6K02T2PBJ9-5441154-5440198
MMRRC Submission 040913-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R3915 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102372739-102373695 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 102373409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 96 (R96H)
Ref Sequence ENSEMBL: ENSMUSP00000151100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657]
AlphaFold Q8VH14
Predicted Effect possibly damaging
Transcript: ENSMUST00000084816
AA Change: R96H

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272
AA Change: R96H

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215657
AA Change: R96H

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik G A 5: 3,627,248 (GRCm39) V75I possibly damaging Het
AA986860 A G 1: 130,670,344 (GRCm39) K189E probably benign Het
Abcf1 C T 17: 36,270,402 (GRCm39) R596H possibly damaging Het
Abtb3 C A 10: 85,468,134 (GRCm39) H810N probably damaging Het
Axl T C 7: 25,460,169 (GRCm39) probably benign Het
Birc6 A G 17: 74,886,603 (GRCm39) K644E probably benign Het
Btnl7-ps T A 17: 34,760,489 (GRCm39) noncoding transcript Het
Car8 A T 4: 8,184,576 (GRCm39) probably benign Het
Ccdc62 C T 5: 124,092,778 (GRCm39) R588C probably damaging Het
Clasp2 T G 9: 113,737,805 (GRCm39) S374A probably damaging Het
Ctnnb1 A G 9: 120,784,717 (GRCm39) H503R probably benign Het
Cwf19l2 A G 9: 3,456,776 (GRCm39) H703R probably damaging Het
Efcab7 A T 4: 99,735,375 (GRCm39) Q133L probably damaging Het
Ehmt2 T C 17: 35,122,443 (GRCm39) S280P probably damaging Het
Eif4a3l1 A T 6: 136,306,420 (GRCm39) T294S probably benign Het
Eomes A G 9: 118,310,341 (GRCm39) M351V probably benign Het
Ets2 G A 16: 95,520,037 (GRCm39) R421H probably damaging Het
Fam222b C G 11: 78,045,756 (GRCm39) P439R probably benign Het
Gbp11 T A 5: 105,478,978 (GRCm39) K153N probably damaging Het
Golim4 T C 3: 75,810,634 (GRCm39) T174A probably damaging Het
Grid1 A G 14: 35,242,684 (GRCm39) Y679C probably damaging Het
Gvin-ps5 A G 7: 105,929,445 (GRCm39) S151P probably benign Het
Ikzf3 T C 11: 98,381,412 (GRCm39) D56G probably damaging Het
Kcnj16 A G 11: 110,916,382 (GRCm39) D348G probably benign Het
Kidins220 T C 12: 25,103,957 (GRCm39) L1319P possibly damaging Het
Lrp1b T A 2: 41,339,248 (GRCm39) D751V probably damaging Het
Macc1 T C 12: 119,410,551 (GRCm39) C440R probably benign Het
Mbd2 T C 18: 70,755,680 (GRCm39) V382A probably benign Het
Or13a17 T A 7: 140,270,888 (GRCm39) D23E probably benign Het
Or6c68 G A 10: 129,158,178 (GRCm39) A229T probably benign Het
Pgs1 T G 11: 117,910,472 (GRCm39) S528A probably benign Het
Pitpnm3 T C 11: 72,003,110 (GRCm39) T67A probably damaging Het
Pnliprp2 T G 19: 58,748,794 (GRCm39) V33G probably damaging Het
Ptn T C 6: 36,720,282 (GRCm39) N90S probably damaging Het
Ptprt A T 2: 161,397,475 (GRCm39) probably benign Het
Ranbp17 G A 11: 33,429,189 (GRCm39) A352V probably benign Het
Rasgrp1 G A 2: 117,119,122 (GRCm39) S505F probably damaging Het
Sesn1 G A 10: 41,770,886 (GRCm39) R139H probably benign Het
Slc17a7 T A 7: 44,818,144 (GRCm39) L23Q probably damaging Het
Slc30a10 G T 1: 185,187,333 (GRCm39) E25* probably null Het
Smco1 A G 16: 32,092,583 (GRCm39) I85V probably benign Het
Vmn1r76 A T 7: 11,664,496 (GRCm39) S239R probably benign Het
Zc3h7a A T 16: 10,974,074 (GRCm39) V237D possibly damaging Het
Other mutations in Or51a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Or51a25 APN 7 102,372,858 (GRCm39) missense probably benign 0.01
R0505:Or51a25 UTSW 7 102,373,236 (GRCm39) missense probably damaging 0.97
R1131:Or51a25 UTSW 7 102,372,887 (GRCm39) missense probably damaging 0.99
R1449:Or51a25 UTSW 7 102,373,397 (GRCm39) missense probably damaging 1.00
R3788:Or51a25 UTSW 7 102,372,694 (GRCm39) splice site probably null
R3980:Or51a25 UTSW 7 102,372,959 (GRCm39) missense probably damaging 0.98
R4647:Or51a25 UTSW 7 102,373,299 (GRCm39) missense probably damaging 1.00
R5242:Or51a25 UTSW 7 102,373,483 (GRCm39) missense probably benign 0.41
R5404:Or51a25 UTSW 7 102,372,807 (GRCm39) missense possibly damaging 0.95
R5464:Or51a25 UTSW 7 102,373,124 (GRCm39) missense possibly damaging 0.85
R5807:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R5965:Or51a25 UTSW 7 102,373,467 (GRCm39) missense probably benign 0.00
R6008:Or51a25 UTSW 7 102,373,574 (GRCm39) missense probably damaging 1.00
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6493:Or51a25 UTSW 7 102,373,287 (GRCm39) missense possibly damaging 0.85
R6756:Or51a25 UTSW 7 102,373,295 (GRCm39) missense probably benign 0.03
R7201:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R7460:Or51a25 UTSW 7 102,373,028 (GRCm39) missense probably benign 0.09
R7695:Or51a25 UTSW 7 102,372,866 (GRCm39) missense probably benign 0.37
R8145:Or51a25 UTSW 7 102,372,937 (GRCm39) missense probably damaging 0.98
R8371:Or51a25 UTSW 7 102,372,790 (GRCm39) missense probably damaging 1.00
R8499:Or51a25 UTSW 7 102,372,932 (GRCm39) missense probably damaging 1.00
R9185:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R9230:Or51a25 UTSW 7 102,372,795 (GRCm39) missense possibly damaging 0.95
X0025:Or51a25 UTSW 7 102,373,022 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCACCCCAATCCTGATGATG -3'
(R):5'- TCTCATGATTGGCATCCCAGG -3'

Sequencing Primer
(F):5'- CCCAATCCTGATGATGACATTG -3'
(R):5'- TCATGATTGGCATCCCAGGACTAG -3'
Posted On 2015-04-17