Incidental Mutation 'R3892:Zmym4'
ID |
309969 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zmym4
|
Ensembl Gene |
ENSMUSG00000042446 |
Gene Name |
zinc finger, MYM-type 4 |
Synonyms |
Zfp262, 6330503C17Rik |
MMRRC Submission |
040804-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.586)
|
Stock # |
R3892 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 126798269 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 786
(I786T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000101714
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
AlphaFold |
A2A791 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000106108
AA Change: I786T
PolyPhen 2
Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000101714 Gene: ENSMUSG00000042446 AA Change: I786T
Domain | Start | End | E-Value | Type |
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
TRASH
|
441 |
479 |
1.77e0 |
SMART |
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
TRASH
|
579 |
615 |
2.82e1 |
SMART |
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000135003
AA Change: I445T
|
SMART Domains |
Protein: ENSMUSP00000120813 Gene: ENSMUSG00000042446 AA Change: I445T
Domain | Start | End | E-Value | Type |
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
TRASH
|
190 |
228 |
1.77e0 |
SMART |
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152952
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
Validation Efficiency |
100% (64/64) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 64 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ascc3 |
T |
A |
10: 50,718,289 (GRCm39) |
I1994N |
probably damaging |
Het |
BC061237 |
A |
G |
14: 44,738,730 (GRCm39) |
D43G |
probably benign |
Het |
Bckdhb |
A |
C |
9: 83,870,863 (GRCm39) |
E124D |
probably damaging |
Het |
Card6 |
T |
C |
15: 5,128,778 (GRCm39) |
T873A |
probably benign |
Het |
Cbs |
C |
A |
17: 31,835,048 (GRCm39) |
C476F |
probably benign |
Het |
Cckbr |
A |
C |
7: 105,075,376 (GRCm39) |
T49P |
probably benign |
Het |
Cd248 |
C |
T |
19: 5,119,534 (GRCm39) |
P461S |
probably damaging |
Het |
Cdh16 |
T |
C |
8: 105,342,959 (GRCm39) |
Y19C |
probably damaging |
Het |
Clip2 |
T |
C |
5: 134,551,847 (GRCm39) |
K92E |
probably damaging |
Het |
Cnnm2 |
T |
A |
19: 46,750,232 (GRCm39) |
C7* |
probably null |
Het |
Ctnnb1 |
T |
G |
9: 120,779,580 (GRCm39) |
|
probably benign |
Het |
Def8 |
T |
C |
8: 124,185,083 (GRCm39) |
|
probably benign |
Het |
Deup1 |
A |
G |
9: 15,511,009 (GRCm39) |
Y257H |
probably damaging |
Het |
Diaph1 |
C |
A |
18: 38,033,691 (GRCm39) |
|
probably benign |
Het |
Dmrta1 |
A |
T |
4: 89,579,831 (GRCm39) |
I264F |
possibly damaging |
Het |
Dnah12 |
A |
G |
14: 26,578,573 (GRCm39) |
M491V |
probably benign |
Het |
Eftud2 |
A |
C |
11: 102,737,013 (GRCm39) |
I590S |
probably damaging |
Het |
Ep300 |
T |
C |
15: 81,504,198 (GRCm39) |
|
probably benign |
Het |
Fam209 |
A |
G |
2: 172,314,618 (GRCm39) |
K36E |
probably damaging |
Het |
Fat3 |
G |
A |
9: 15,909,567 (GRCm39) |
S2145F |
probably damaging |
Het |
Flg |
A |
T |
3: 93,186,833 (GRCm39) |
Q95L |
probably benign |
Het |
Gabrr2 |
A |
G |
4: 33,081,348 (GRCm39) |
Y4C |
probably damaging |
Het |
Ggcx |
G |
A |
6: 72,395,355 (GRCm39) |
V149M |
probably damaging |
Het |
Gm10801 |
T |
G |
2: 98,494,246 (GRCm39) |
|
probably null |
Het |
H2-M10.1 |
T |
A |
17: 36,635,281 (GRCm39) |
Q250L |
possibly damaging |
Het |
Hecw2 |
A |
T |
1: 53,965,280 (GRCm39) |
N515K |
probably benign |
Het |
Hmcn1 |
A |
T |
1: 150,510,946 (GRCm39) |
D3592E |
probably damaging |
Het |
Klf5 |
T |
A |
14: 99,536,509 (GRCm39) |
F27I |
probably benign |
Het |
Krt1 |
T |
A |
15: 101,758,847 (GRCm39) |
S106C |
unknown |
Het |
Lrrc14b |
T |
C |
13: 74,511,787 (GRCm39) |
S98G |
probably benign |
Het |
Lrrc7 |
A |
G |
3: 157,866,333 (GRCm39) |
V1136A |
probably benign |
Het |
Map3k11 |
G |
T |
19: 5,752,311 (GRCm39) |
C831F |
probably benign |
Het |
Mccc2 |
T |
C |
13: 100,104,241 (GRCm39) |
T303A |
probably benign |
Het |
Mipep |
T |
C |
14: 61,046,444 (GRCm39) |
L322P |
probably damaging |
Het |
Mob1b |
T |
A |
5: 88,901,061 (GRCm39) |
I156K |
probably damaging |
Het |
Myd88 |
T |
C |
9: 119,166,882 (GRCm39) |
D225G |
possibly damaging |
Het |
Nos1ap |
T |
C |
1: 170,177,025 (GRCm39) |
Y126C |
probably damaging |
Het |
Nuak2 |
G |
T |
1: 132,259,223 (GRCm39) |
A342S |
possibly damaging |
Het |
Or10ah1-ps1 |
G |
T |
5: 143,123,152 (GRCm39) |
S290R |
probably benign |
Het |
Or4f15 |
A |
C |
2: 111,813,486 (GRCm39) |
M311R |
probably benign |
Het |
Or7e165 |
T |
G |
9: 19,695,011 (GRCm39) |
I194S |
probably benign |
Het |
Pcdhb16 |
A |
T |
18: 37,612,422 (GRCm39) |
I461F |
probably benign |
Het |
Pcdhga10 |
A |
C |
18: 37,882,534 (GRCm39) |
H765P |
probably benign |
Het |
Plxna4 |
C |
A |
6: 32,192,589 (GRCm39) |
D791Y |
probably damaging |
Het |
Pole |
T |
G |
5: 110,484,305 (GRCm39) |
I320M |
probably damaging |
Het |
Psg23 |
G |
T |
7: 18,345,966 (GRCm39) |
T243N |
probably damaging |
Het |
Ptma-ps1 |
A |
G |
7: 23,763,543 (GRCm39) |
|
noncoding transcript |
Het |
Ptprk |
A |
T |
10: 28,139,617 (GRCm39) |
Q114L |
probably benign |
Het |
Pum1 |
T |
C |
4: 130,491,393 (GRCm39) |
L774P |
probably damaging |
Het |
Rabgef1 |
A |
G |
5: 130,237,520 (GRCm39) |
|
probably benign |
Het |
Rasef |
A |
G |
4: 73,698,634 (GRCm39) |
V9A |
probably benign |
Het |
Rcbtb1 |
T |
A |
14: 59,465,804 (GRCm39) |
H382Q |
possibly damaging |
Het |
Robo4 |
CGG |
CG |
9: 37,322,786 (GRCm39) |
|
probably null |
Het |
Sacs |
T |
G |
14: 61,441,836 (GRCm39) |
I1294R |
probably damaging |
Het |
Slc19a3 |
A |
T |
1: 83,000,678 (GRCm39) |
F113Y |
probably damaging |
Het |
Snrnp48 |
G |
A |
13: 38,401,365 (GRCm39) |
S204N |
possibly damaging |
Het |
Sp3 |
A |
G |
2: 72,809,376 (GRCm39) |
|
probably benign |
Het |
St8sia6 |
G |
A |
2: 13,677,335 (GRCm39) |
H161Y |
probably benign |
Het |
Strip2 |
A |
T |
6: 29,917,074 (GRCm39) |
|
probably benign |
Het |
Trank1 |
T |
C |
9: 111,193,827 (GRCm39) |
V617A |
probably benign |
Het |
Uvssa |
T |
A |
5: 33,547,096 (GRCm39) |
S221T |
probably benign |
Het |
Vmn2r75 |
A |
T |
7: 85,813,494 (GRCm39) |
L436Q |
probably null |
Het |
Wdfy4 |
T |
C |
14: 32,769,237 (GRCm39) |
E2076G |
probably damaging |
Het |
Zfp407 |
C |
T |
18: 84,578,477 (GRCm39) |
V879I |
probably damaging |
Het |
|
Other mutations in Zmym4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
R0423:Zmym4
|
UTSW |
4 |
126,776,112 (GRCm39) |
splice site |
probably benign |
|
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R8313:Zmym4
|
UTSW |
4 |
126,804,762 (GRCm39) |
missense |
probably benign |
0.19 |
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
R9233:Zmym4
|
UTSW |
4 |
126,776,310 (GRCm39) |
missense |
probably damaging |
0.99 |
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
R9468:Zmym4
|
UTSW |
4 |
126,800,993 (GRCm39) |
missense |
probably benign |
0.01 |
R9542:Zmym4
|
UTSW |
4 |
126,799,164 (GRCm39) |
missense |
probably benign |
0.00 |
R9756:Zmym4
|
UTSW |
4 |
126,771,502 (GRCm39) |
missense |
probably damaging |
1.00 |
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GACATGTATGTGCTACTGTACAC -3'
(R):5'- ACCTGTCAGTTGGTTAAGTCC -3'
Sequencing Primer
(F):5'- ATCCCCCAAATGTTGCACTAATTG -3'
(R):5'- GGTTAAGTCCCATGTGTGAAAAC -3'
|
Posted On |
2015-04-17 |