Incidental Mutation 'R3892:Map3k11'
ID 310017
Institutional Source Beutler Lab
Gene Symbol Map3k11
Ensembl Gene ENSMUSG00000004054
Gene Name mitogen-activated protein kinase kinase kinase 11
Synonyms Mlk3, 2610017K16Rik
MMRRC Submission 040804-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # R3892 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 5738770-5752893 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 5752311 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 831 (C831F)
Ref Sequence ENSEMBL: ENSMUSP00000004156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004156] [ENSMUST00000052448]
AlphaFold Q80XI6
Predicted Effect probably benign
Transcript: ENSMUST00000004156
AA Change: C831F

PolyPhen 2 Score 0.133 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000004156
Gene: ENSMUSG00000004054
AA Change: C831F

DomainStartEndE-ValueType
low complexity region 11 36 N/A INTRINSIC
SH3 45 105 6.79e-19 SMART
TyrKc 118 377 6.83e-81 SMART
coiled coil region 398 444 N/A INTRINSIC
low complexity region 467 476 N/A INTRINSIC
low complexity region 593 610 N/A INTRINSIC
low complexity region 614 632 N/A INTRINSIC
low complexity region 676 697 N/A INTRINSIC
low complexity region 759 778 N/A INTRINSIC
low complexity region 786 805 N/A INTRINSIC
low complexity region 809 820 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000052448
SMART Domains Protein: ENSMUSP00000051278
Gene: ENSMUSG00000024936

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Ion_trans_2 67 145 3.2e-14 PFAM
Pfam:Ion_trans_2 175 261 8.8e-12 PFAM
Meta Mutation Damage Score 0.0700 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted or spontaneous mutation display a pattern of dark red stripes of thin dorsal epithelium during pre-wean development, and necrotic dental pulp has been reported for the spontaneous mutant. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 T A 10: 50,718,289 (GRCm39) I1994N probably damaging Het
BC061237 A G 14: 44,738,730 (GRCm39) D43G probably benign Het
Bckdhb A C 9: 83,870,863 (GRCm39) E124D probably damaging Het
Card6 T C 15: 5,128,778 (GRCm39) T873A probably benign Het
Cbs C A 17: 31,835,048 (GRCm39) C476F probably benign Het
Cckbr A C 7: 105,075,376 (GRCm39) T49P probably benign Het
Cd248 C T 19: 5,119,534 (GRCm39) P461S probably damaging Het
Cdh16 T C 8: 105,342,959 (GRCm39) Y19C probably damaging Het
Clip2 T C 5: 134,551,847 (GRCm39) K92E probably damaging Het
Cnnm2 T A 19: 46,750,232 (GRCm39) C7* probably null Het
Ctnnb1 T G 9: 120,779,580 (GRCm39) probably benign Het
Def8 T C 8: 124,185,083 (GRCm39) probably benign Het
Deup1 A G 9: 15,511,009 (GRCm39) Y257H probably damaging Het
Diaph1 C A 18: 38,033,691 (GRCm39) probably benign Het
Dmrta1 A T 4: 89,579,831 (GRCm39) I264F possibly damaging Het
Dnah12 A G 14: 26,578,573 (GRCm39) M491V probably benign Het
Eftud2 A C 11: 102,737,013 (GRCm39) I590S probably damaging Het
Ep300 T C 15: 81,504,198 (GRCm39) probably benign Het
Fam209 A G 2: 172,314,618 (GRCm39) K36E probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Flg A T 3: 93,186,833 (GRCm39) Q95L probably benign Het
Gabrr2 A G 4: 33,081,348 (GRCm39) Y4C probably damaging Het
Ggcx G A 6: 72,395,355 (GRCm39) V149M probably damaging Het
Gm10801 T G 2: 98,494,246 (GRCm39) probably null Het
H2-M10.1 T A 17: 36,635,281 (GRCm39) Q250L possibly damaging Het
Hecw2 A T 1: 53,965,280 (GRCm39) N515K probably benign Het
Hmcn1 A T 1: 150,510,946 (GRCm39) D3592E probably damaging Het
Klf5 T A 14: 99,536,509 (GRCm39) F27I probably benign Het
Krt1 T A 15: 101,758,847 (GRCm39) S106C unknown Het
Lrrc14b T C 13: 74,511,787 (GRCm39) S98G probably benign Het
Lrrc7 A G 3: 157,866,333 (GRCm39) V1136A probably benign Het
Mccc2 T C 13: 100,104,241 (GRCm39) T303A probably benign Het
Mipep T C 14: 61,046,444 (GRCm39) L322P probably damaging Het
Mob1b T A 5: 88,901,061 (GRCm39) I156K probably damaging Het
Myd88 T C 9: 119,166,882 (GRCm39) D225G possibly damaging Het
Nos1ap T C 1: 170,177,025 (GRCm39) Y126C probably damaging Het
Nuak2 G T 1: 132,259,223 (GRCm39) A342S possibly damaging Het
Or10ah1-ps1 G T 5: 143,123,152 (GRCm39) S290R probably benign Het
Or4f15 A C 2: 111,813,486 (GRCm39) M311R probably benign Het
Or7e165 T G 9: 19,695,011 (GRCm39) I194S probably benign Het
Pcdhb16 A T 18: 37,612,422 (GRCm39) I461F probably benign Het
Pcdhga10 A C 18: 37,882,534 (GRCm39) H765P probably benign Het
Plxna4 C A 6: 32,192,589 (GRCm39) D791Y probably damaging Het
Pole T G 5: 110,484,305 (GRCm39) I320M probably damaging Het
Psg23 G T 7: 18,345,966 (GRCm39) T243N probably damaging Het
Ptma-ps1 A G 7: 23,763,543 (GRCm39) noncoding transcript Het
Ptprk A T 10: 28,139,617 (GRCm39) Q114L probably benign Het
Pum1 T C 4: 130,491,393 (GRCm39) L774P probably damaging Het
Rabgef1 A G 5: 130,237,520 (GRCm39) probably benign Het
Rasef A G 4: 73,698,634 (GRCm39) V9A probably benign Het
Rcbtb1 T A 14: 59,465,804 (GRCm39) H382Q possibly damaging Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Sacs T G 14: 61,441,836 (GRCm39) I1294R probably damaging Het
Slc19a3 A T 1: 83,000,678 (GRCm39) F113Y probably damaging Het
Snrnp48 G A 13: 38,401,365 (GRCm39) S204N possibly damaging Het
Sp3 A G 2: 72,809,376 (GRCm39) probably benign Het
St8sia6 G A 2: 13,677,335 (GRCm39) H161Y probably benign Het
Strip2 A T 6: 29,917,074 (GRCm39) probably benign Het
Trank1 T C 9: 111,193,827 (GRCm39) V617A probably benign Het
Uvssa T A 5: 33,547,096 (GRCm39) S221T probably benign Het
Vmn2r75 A T 7: 85,813,494 (GRCm39) L436Q probably null Het
Wdfy4 T C 14: 32,769,237 (GRCm39) E2076G probably damaging Het
Zfp407 C T 18: 84,578,477 (GRCm39) V879I probably damaging Het
Zmym4 A G 4: 126,798,269 (GRCm39) I786T probably benign Het
Other mutations in Map3k11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02017:Map3k11 APN 19 5,747,651 (GRCm39) missense possibly damaging 0.91
IGL02581:Map3k11 APN 19 5,750,834 (GRCm39) missense probably benign
pow UTSW 19 5,750,622 (GRCm39) missense probably benign 0.03
yow UTSW 19 5,747,429 (GRCm39) missense probably benign 0.34
R0130:Map3k11 UTSW 19 5,740,843 (GRCm39) missense probably damaging 1.00
R0193:Map3k11 UTSW 19 5,745,874 (GRCm39) missense probably damaging 0.99
R1621:Map3k11 UTSW 19 5,740,834 (GRCm39) missense probably damaging 1.00
R1736:Map3k11 UTSW 19 5,747,429 (GRCm39) missense probably benign 0.34
R1791:Map3k11 UTSW 19 5,745,600 (GRCm39) nonsense probably null
R3500:Map3k11 UTSW 19 5,740,275 (GRCm39) start codon destroyed probably benign 0.08
R3836:Map3k11 UTSW 19 5,740,831 (GRCm39) missense possibly damaging 0.71
R4303:Map3k11 UTSW 19 5,740,852 (GRCm39) missense probably damaging 1.00
R4513:Map3k11 UTSW 19 5,752,238 (GRCm39) missense probably damaging 0.97
R4613:Map3k11 UTSW 19 5,747,499 (GRCm39) missense probably damaging 0.98
R4613:Map3k11 UTSW 19 5,747,498 (GRCm39) missense probably benign 0.18
R4631:Map3k11 UTSW 19 5,740,941 (GRCm39) missense probably benign 0.30
R4780:Map3k11 UTSW 19 5,740,966 (GRCm39) missense probably damaging 0.99
R5213:Map3k11 UTSW 19 5,740,669 (GRCm39) missense probably damaging 0.99
R5266:Map3k11 UTSW 19 5,750,622 (GRCm39) missense probably benign 0.03
R5372:Map3k11 UTSW 19 5,740,990 (GRCm39) missense probably damaging 1.00
R5736:Map3k11 UTSW 19 5,746,739 (GRCm39) missense probably damaging 1.00
R5899:Map3k11 UTSW 19 5,745,937 (GRCm39) critical splice donor site probably null
R6052:Map3k11 UTSW 19 5,747,430 (GRCm39) missense probably benign 0.01
R6388:Map3k11 UTSW 19 5,740,279 (GRCm39) missense probably damaging 0.96
R6623:Map3k11 UTSW 19 5,745,631 (GRCm39) missense probably damaging 0.97
R6975:Map3k11 UTSW 19 5,740,755 (GRCm39) missense possibly damaging 0.91
R7309:Map3k11 UTSW 19 5,740,486 (GRCm39) missense probably damaging 0.99
R7771:Map3k11 UTSW 19 5,740,636 (GRCm39) missense probably damaging 0.99
R7815:Map3k11 UTSW 19 5,745,667 (GRCm39) missense possibly damaging 0.89
R8988:Map3k11 UTSW 19 5,752,166 (GRCm39) missense probably damaging 1.00
R9130:Map3k11 UTSW 19 5,746,038 (GRCm39) missense possibly damaging 0.69
R9502:Map3k11 UTSW 19 5,740,624 (GRCm39) missense probably damaging 1.00
X0025:Map3k11 UTSW 19 5,746,223 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- CGTAGCCGTATTGACCCATG -3'
(R):5'- TCAGGGGTCCCTACAGTTTGTAG -3'

Sequencing Primer
(F):5'- ATTGACCCATGGAGCTTCG -3'
(R):5'- GTAGTGTTCCTGACCCCCAAAG -3'
Posted On 2015-04-17