Incidental Mutation 'R3749:Tas2r136'
ID 310092
Institutional Source Beutler Lab
Gene Symbol Tas2r136
Ensembl Gene ENSMUSG00000053217
Gene Name taste receptor, type 2, member 136
Synonyms Tas2r36, mt2r52
MMRRC Submission 040734-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R3749 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 132754142-132755125 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 132754200 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 309 (F309Y)
Ref Sequence ENSEMBL: ENSMUSP00000070791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065532]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000065532
AA Change: F309Y

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000070791
Gene: ENSMUSG00000053217
AA Change: F309Y

DomainStartEndE-ValueType
Pfam:TAS2R 23 317 8.4e-68 PFAM
Meta Mutation Damage Score 0.2471 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam12 T C 7: 133,774,594 (GRCm39) D5G probably damaging Het
Adam19 A T 11: 46,028,437 (GRCm39) D690V probably benign Het
Ankib1 G T 5: 3,784,097 (GRCm39) P293Q probably damaging Het
Arhgap19 T A 19: 41,762,518 (GRCm39) E461V probably damaging Het
Bckdk C A 7: 127,504,590 (GRCm39) R105S probably damaging Het
Bub1b T A 2: 118,445,936 (GRCm39) N319K possibly damaging Het
Ccdc40 T C 11: 119,155,252 (GRCm39) V1164A probably benign Het
Cfhr1 C A 1: 139,485,372 (GRCm39) probably null Het
Colq A T 14: 31,271,410 (GRCm39) probably benign Het
Daam1 C A 12: 72,017,940 (GRCm39) D716E probably damaging Het
Dnah17 T C 11: 117,973,742 (GRCm39) S1935G probably benign Het
Dnah8 A T 17: 31,003,148 (GRCm39) K3616* probably null Het
Faap24 A T 7: 35,092,437 (GRCm39) V160D possibly damaging Het
Gpc1 C A 1: 92,785,304 (GRCm39) C414* probably null Het
Igkv9-120 G A 6: 68,026,985 (GRCm39) A7T probably benign Het
Kcnu1 T A 8: 26,376,798 (GRCm39) C391S probably null Het
Lrba T G 3: 86,283,260 (GRCm39) L1858R probably damaging Het
Lrp10 A T 14: 54,706,723 (GRCm39) N520I possibly damaging Het
Marchf6 A G 15: 31,462,160 (GRCm39) V856A probably benign Het
Mfsd1 T C 3: 67,490,286 (GRCm39) S46P probably benign Het
Mme T A 3: 63,250,961 (GRCm39) V334E probably damaging Het
Mroh2b G A 15: 4,981,728 (GRCm39) W1513* probably null Het
Nuf2 T A 1: 169,352,945 (GRCm39) N20I probably damaging Het
Obsl1 T C 1: 75,474,890 (GRCm39) T642A probably benign Het
Olfm1 C T 2: 28,098,100 (GRCm39) T54I probably damaging Het
Or10c1 G A 17: 37,522,691 (GRCm39) R18C possibly damaging Het
Or6c3b C T 10: 129,527,830 (GRCm39) V27I probably benign Het
Osbpl7 T C 11: 96,946,879 (GRCm39) V223A probably damaging Het
Patj A G 4: 98,357,837 (GRCm39) Y701C probably damaging Het
Pkdrej T A 15: 85,705,278 (GRCm39) K219N probably damaging Het
Scn2a T G 2: 65,544,115 (GRCm39) V832G probably damaging Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Slc25a25 G T 2: 32,310,392 (GRCm39) N122K probably benign Het
Slk T G 19: 47,608,248 (GRCm39) D400E possibly damaging Het
Spon1 T C 7: 113,365,621 (GRCm39) L19P probably damaging Het
Spon1 T A 7: 113,616,024 (GRCm39) V297E possibly damaging Het
Supt16 A G 14: 52,417,596 (GRCm39) L306P probably damaging Het
Syne1 C T 10: 5,002,267 (GRCm39) probably benign Het
Terb1 T C 8: 105,223,466 (GRCm39) D114G probably damaging Het
Tlr5 T C 1: 182,802,004 (GRCm39) I436T probably benign Het
Tpcn2 T C 7: 144,809,260 (GRCm39) H682R probably damaging Het
Tpi1 T A 6: 124,789,754 (GRCm39) S130C probably damaging Het
Ttn G A 2: 76,584,350 (GRCm39) H22253Y probably damaging Het
Uggt2 A T 14: 119,295,084 (GRCm39) V38E probably benign Het
Vmn1r158 A C 7: 22,489,639 (GRCm39) L190W probably damaging Het
Vwa5b2 A G 16: 20,417,076 (GRCm39) probably benign Het
Wnt2 T C 6: 18,023,167 (GRCm39) I161V probably benign Het
Zdhhc25 C T 15: 88,485,226 (GRCm39) S187L probably benign Het
Zfhx4 G A 3: 5,308,225 (GRCm39) E484K possibly damaging Het
Zkscan1 T C 5: 138,099,703 (GRCm39) S476P probably damaging Het
Zmynd8 A G 2: 165,647,118 (GRCm39) Y945H probably damaging Het
Other mutations in Tas2r136
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00678:Tas2r136 APN 6 132,754,161 (GRCm39) missense probably damaging 1.00
IGL02414:Tas2r136 APN 6 132,754,494 (GRCm39) missense possibly damaging 0.87
IGL02662:Tas2r136 APN 6 132,754,671 (GRCm39) missense probably damaging 1.00
R0607:Tas2r136 UTSW 6 132,754,375 (GRCm39) missense probably benign 0.09
R0785:Tas2r136 UTSW 6 132,754,890 (GRCm39) missense probably benign
R1727:Tas2r136 UTSW 6 132,754,753 (GRCm39) missense possibly damaging 0.63
R2101:Tas2r136 UTSW 6 132,754,495 (GRCm39) missense probably benign 0.09
R2975:Tas2r136 UTSW 6 132,754,972 (GRCm39) missense probably damaging 1.00
R3080:Tas2r136 UTSW 6 132,754,972 (GRCm39) missense probably damaging 1.00
R3746:Tas2r136 UTSW 6 132,754,200 (GRCm39) missense probably damaging 0.97
R3750:Tas2r136 UTSW 6 132,754,200 (GRCm39) missense probably damaging 0.97
R4362:Tas2r136 UTSW 6 132,754,972 (GRCm39) missense probably damaging 1.00
R4411:Tas2r136 UTSW 6 132,754,972 (GRCm39) missense probably damaging 1.00
R4413:Tas2r136 UTSW 6 132,754,972 (GRCm39) missense probably damaging 1.00
R4803:Tas2r136 UTSW 6 132,754,455 (GRCm39) missense probably damaging 1.00
R5283:Tas2r136 UTSW 6 132,754,374 (GRCm39) missense probably damaging 0.99
R5343:Tas2r136 UTSW 6 132,755,043 (GRCm39) missense probably benign 0.00
R5738:Tas2r136 UTSW 6 132,754,707 (GRCm39) missense probably damaging 1.00
R5872:Tas2r136 UTSW 6 132,754,294 (GRCm39) missense possibly damaging 0.46
R6770:Tas2r136 UTSW 6 132,754,345 (GRCm39) missense probably benign 0.03
R7326:Tas2r136 UTSW 6 132,754,869 (GRCm39) missense possibly damaging 0.65
R7845:Tas2r136 UTSW 6 132,754,833 (GRCm39) missense probably benign 0.05
R7900:Tas2r136 UTSW 6 132,754,599 (GRCm39) missense possibly damaging 0.93
R8422:Tas2r136 UTSW 6 132,754,290 (GRCm39) missense probably damaging 0.96
R8783:Tas2r136 UTSW 6 132,754,612 (GRCm39) missense probably benign 0.08
R8899:Tas2r136 UTSW 6 132,754,323 (GRCm39) missense probably benign
R9126:Tas2r136 UTSW 6 132,754,584 (GRCm39) missense probably damaging 1.00
R9627:Tas2r136 UTSW 6 132,754,948 (GRCm39) missense possibly damaging 0.61
R9642:Tas2r136 UTSW 6 132,754,462 (GRCm39) missense probably benign 0.13
R9749:Tas2r136 UTSW 6 132,755,106 (GRCm39) missense probably damaging 1.00
R9765:Tas2r136 UTSW 6 132,754,813 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ACTTATGCCTGGCTTCATAATTCTG -3'
(R):5'- TCAACCCACATTAAGGTTTTGCAAG -3'

Sequencing Primer
(F):5'- GCCTGGCTTCATAATTCTGAAAAATG -3'
(R):5'- CCCACATTAAGGTTTTGCAAGTTTTG -3'
Posted On 2015-04-17