Incidental Mutation 'R3750:Marcks'
ID 310153
Institutional Source Beutler Lab
Gene Symbol Marcks
Ensembl Gene ENSMUSG00000069662
Gene Name myristoylated alanine rich protein kinase C substrate
Synonyms Macs
MMRRC Submission 040735-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3750 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 37009371-37014916 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 37016866 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000090245 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092584]
AlphaFold P26645
PDB Structure Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin [X-RAY DIFFRACTION]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000062667
SMART Domains Protein: ENSMUSP00000058515
Gene: ENSMUSG00000046463

DomainStartEndE-ValueType
low complexity region 47 87 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000092584
SMART Domains Protein: ENSMUSP00000090245
Gene: ENSMUSG00000069662

DomainStartEndE-ValueType
Pfam:MARCKS 2 309 6e-109 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188813
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191067
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217338
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (38/38)
MGI Phenotype PHENOTYPE: Homozygous null mutants exhibit perinatal lethality, absence of the corpus callosum and other forebrain commisures, neuronal ectopia, and defects of cortical and retinal lamination. About one-fourth of fetuses are exencephalic. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh C A 5: 77,036,501 (GRCm39) E347* probably null Het
Adam12 T C 7: 133,774,594 (GRCm39) D5G probably damaging Het
Adam26b A C 8: 43,974,234 (GRCm39) V256G probably benign Het
Ago1 A G 4: 126,354,837 (GRCm39) I125T probably benign Het
Bckdk C A 7: 127,504,590 (GRCm39) R105S probably damaging Het
Bub1b T A 2: 118,445,936 (GRCm39) N319K possibly damaging Het
Clcn6 G T 4: 148,108,644 (GRCm39) C128* probably null Het
Col6a4 C A 9: 105,897,864 (GRCm39) probably null Het
Cyp4v3 G A 8: 45,768,745 (GRCm39) R272* probably null Het
Dlg5 G A 14: 24,215,328 (GRCm39) A665V probably damaging Het
Foxd1 G C 13: 98,492,424 (GRCm39) A433P unknown Het
Hsd17b3 A T 13: 64,210,993 (GRCm39) probably null Het
Kcnc4 A G 3: 107,355,506 (GRCm39) V314A probably benign Het
Lrba T G 3: 86,283,260 (GRCm39) L1858R probably damaging Het
Mroh2b G A 15: 4,981,728 (GRCm39) W1513* probably null Het
Nefh A G 11: 4,889,937 (GRCm39) V894A probably benign Het
Pdzph1 A T 17: 59,280,331 (GRCm39) Y650* probably null Het
Plce1 A C 19: 38,766,343 (GRCm39) I2109L probably benign Het
Pramel18 T A 4: 101,767,073 (GRCm39) D107E possibly damaging Het
Primpol A T 8: 47,052,848 (GRCm39) D154E probably benign Het
Relch C T 1: 105,681,302 (GRCm39) T1178I probably damaging Het
Rtca A T 3: 116,286,650 (GRCm39) F327L probably benign Het
Scn2a T G 2: 65,544,115 (GRCm39) V832G probably damaging Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Skil A G 3: 31,170,983 (GRCm39) N354S probably benign Het
Slk T G 19: 47,608,248 (GRCm39) D400E possibly damaging Het
Spata31 G T 13: 65,069,557 (GRCm39) L568F probably benign Het
Spon1 T C 7: 113,365,621 (GRCm39) L19P probably damaging Het
Spon1 T A 7: 113,616,024 (GRCm39) V297E possibly damaging Het
Tas2r136 A T 6: 132,754,200 (GRCm39) F309Y probably damaging Het
Tcp11l1 A G 2: 104,528,887 (GRCm39) I137T probably damaging Het
Ttn G A 2: 76,584,350 (GRCm39) H22253Y probably damaging Het
Upf1 G T 8: 70,786,000 (GRCm39) N975K possibly damaging Het
Usp1 C T 4: 98,822,357 (GRCm39) probably null Het
Zfhx4 G A 3: 5,308,225 (GRCm39) E484K possibly damaging Het
Zswim4 G A 8: 84,938,676 (GRCm39) P1069S possibly damaging Het
Other mutations in Marcks
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00498:Marcks APN 10 37,014,513 (GRCm39) missense probably damaging 1.00
R0675:Marcks UTSW 10 37,017,181 (GRCm39) unclassified probably benign
R5385:Marcks UTSW 10 37,014,453 (GRCm39) missense probably damaging 1.00
R5608:Marcks UTSW 10 37,012,912 (GRCm39) missense probably damaging 0.99
R5838:Marcks UTSW 10 37,012,163 (GRCm39) missense probably benign 0.39
R7522:Marcks UTSW 10 37,012,577 (GRCm39) missense unknown
R9310:Marcks UTSW 10 37,012,487 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GAAAAGTCAACTGGGCTGGTCC -3'
(R):5'- TCAGCTGCAAAGTAGGGACC -3'

Sequencing Primer
(F):5'- TCAACTGGGCTGGTCCAACAC -3'
(R):5'- ACAGCCCGCGTGTTTAC -3'
Posted On 2015-04-17