Incidental Mutation 'R3890:Prdm15'
ID 310369
Institutional Source Beutler Lab
Gene Symbol Prdm15
Ensembl Gene ENSMUSG00000014039
Gene Name PR domain containing 15
Synonyms Zfp298, E130018M06Rik
MMRRC Submission 040802-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3890 (G1)
Quality Score 218
Status Validated
Chromosome 16
Chromosomal Location 97592667-97653050 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 97600771 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 829 (H829R)
Ref Sequence ENSEMBL: ENSMUSP00000113791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095849] [ENSMUST00000121584] [ENSMUST00000142295]
AlphaFold E9Q8T2
Predicted Effect probably damaging
Transcript: ENSMUST00000095849
AA Change: H855R

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000093533
Gene: ENSMUSG00000014039
AA Change: H855R

DomainStartEndE-ValueType
SET 75 191 5.96e-1 SMART
ZnF_C2H2 223 245 3.99e0 SMART
low complexity region 290 303 N/A INTRINSIC
ZnF_C2H2 402 424 3.89e-3 SMART
ZnF_C2H2 434 457 2.75e-3 SMART
ZnF_C2H2 468 488 1.88e2 SMART
ZnF_C2H2 495 517 5.42e-2 SMART
ZnF_C2H2 522 544 1.36e-2 SMART
ZnF_C2H2 571 593 6.23e-2 SMART
ZnF_C2H2 598 620 2.75e-3 SMART
low complexity region 642 657 N/A INTRINSIC
ZnF_C2H2 661 684 2.17e-1 SMART
ZnF_C2H2 689 711 3.24e0 SMART
ZnF_C2H2 725 747 1.38e-3 SMART
ZnF_C2H2 753 775 5.67e-5 SMART
ZnF_C2H2 781 803 3.11e-2 SMART
ZnF_C2H2 809 831 8.34e-3 SMART
ZnF_C2H2 837 859 4.79e-3 SMART
ZnF_C2H2 865 888 4.79e-3 SMART
ZnF_C2H2 894 917 5.06e-2 SMART
low complexity region 948 959 N/A INTRINSIC
low complexity region 1148 1170 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000121584
AA Change: H829R

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000113791
Gene: ENSMUSG00000014039
AA Change: H829R

DomainStartEndE-ValueType
SET 49 165 5.96e-1 SMART
ZnF_C2H2 197 219 3.99e0 SMART
low complexity region 264 277 N/A INTRINSIC
ZnF_C2H2 376 398 3.89e-3 SMART
ZnF_C2H2 408 431 2.75e-3 SMART
ZnF_C2H2 442 462 1.88e2 SMART
ZnF_C2H2 469 491 5.42e-2 SMART
ZnF_C2H2 496 518 1.36e-2 SMART
ZnF_C2H2 545 567 6.23e-2 SMART
ZnF_C2H2 572 594 2.75e-3 SMART
low complexity region 616 631 N/A INTRINSIC
ZnF_C2H2 635 658 2.17e-1 SMART
ZnF_C2H2 663 685 3.24e0 SMART
ZnF_C2H2 699 721 1.38e-3 SMART
ZnF_C2H2 727 749 5.67e-5 SMART
ZnF_C2H2 755 777 3.11e-2 SMART
ZnF_C2H2 783 805 8.34e-3 SMART
ZnF_C2H2 811 833 4.79e-3 SMART
ZnF_C2H2 839 862 4.79e-3 SMART
ZnF_C2H2 868 891 5.06e-2 SMART
low complexity region 922 933 N/A INTRINSIC
low complexity region 1122 1144 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126916
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131951
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136529
Predicted Effect probably benign
Transcript: ENSMUST00000142295
SMART Domains Protein: ENSMUSP00000120497
Gene: ENSMUSG00000014039

DomainStartEndE-ValueType
SET 49 165 5.96e-1 SMART
low complexity region 230 243 N/A INTRINSIC
ZnF_C2H2 342 364 3.89e-3 SMART
ZnF_C2H2 369 392 2.75e-3 SMART
ZnF_C2H2 403 423 1.88e2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231599
Meta Mutation Damage Score 0.9523 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 98% (60/61)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029H14Rik T C 8: 13,604,700 (GRCm39) Y201C probably damaging Het
Adam10 A G 9: 70,676,136 (GRCm39) T624A probably benign Het
Atf2 T C 2: 73,693,557 (GRCm39) S2G probably damaging Het
Atf7ip T C 6: 136,564,043 (GRCm39) V762A possibly damaging Het
Cacna1e C T 1: 154,359,299 (GRCm39) R265Q probably damaging Het
Cckbr A C 7: 105,075,376 (GRCm39) T49P probably benign Het
Clip2 T C 5: 134,551,847 (GRCm39) K92E probably damaging Het
Clrn3 T C 7: 135,120,194 (GRCm39) T131A possibly damaging Het
Cntrl T G 2: 35,060,492 (GRCm39) C1342G probably benign Het
Def8 T C 8: 124,185,083 (GRCm39) probably benign Het
Dennd4a T C 9: 64,779,310 (GRCm39) S598P probably damaging Het
Deup1 A G 9: 15,511,009 (GRCm39) Y257H probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ect2 T C 3: 27,192,689 (GRCm39) D387G probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Fmo4 A T 1: 162,621,624 (GRCm39) I529N probably benign Het
Frs3 A G 17: 48,014,360 (GRCm39) D351G probably damaging Het
Gcat T A 15: 78,921,376 (GRCm39) V378D probably damaging Het
Hmcn1 A T 1: 150,510,946 (GRCm39) D3592E probably damaging Het
Hspa4l A T 3: 40,736,026 (GRCm39) Q570L possibly damaging Het
Ifi213 A G 1: 173,394,822 (GRCm39) I571T probably benign Het
Lsamp T C 16: 39,805,054 (GRCm39) V11A probably benign Het
Mettl1 T C 10: 126,880,998 (GRCm39) probably null Het
Mettl15 A G 2: 109,021,924 (GRCm39) I127T probably benign Het
Mipep T C 14: 61,046,444 (GRCm39) L322P probably damaging Het
Mob1b T A 5: 88,901,061 (GRCm39) I156K probably damaging Het
Mobp G A 9: 119,997,022 (GRCm39) C51Y probably damaging Het
Ms4a3 T C 19: 11,610,271 (GRCm39) N97S probably benign Het
Myrip A G 9: 120,251,324 (GRCm39) E210G probably damaging Het
Nos1ap T C 1: 170,177,025 (GRCm39) Y126C probably damaging Het
Nuak2 G T 1: 132,259,223 (GRCm39) A342S possibly damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or10ah1-ps1 G T 5: 143,123,152 (GRCm39) S290R probably benign Het
Or2aj5 A G 16: 19,425,205 (GRCm39) I71T probably damaging Het
Or7e165 T G 9: 19,695,011 (GRCm39) I194S probably benign Het
Pdgfra A G 5: 75,328,588 (GRCm39) N240S probably null Het
Pdxdc1 T C 16: 13,654,312 (GRCm39) T759A probably benign Het
Pex2 C T 3: 5,626,008 (GRCm39) C267Y probably damaging Het
Pgghg T C 7: 140,525,616 (GRCm39) I473T probably damaging Het
Pum1 T C 4: 130,491,393 (GRCm39) L774P probably damaging Het
Rcbtb1 T A 14: 59,465,804 (GRCm39) H382Q possibly damaging Het
Rprd2 A T 3: 95,672,536 (GRCm39) F956I probably damaging Het
Samd1 G A 8: 84,724,361 (GRCm39) probably benign Het
Slc4a11 A T 2: 130,527,705 (GRCm39) S592T probably damaging Het
Slc5a4b A G 10: 75,898,094 (GRCm39) V540A probably benign Het
Slfn8 G A 11: 82,895,270 (GRCm39) T512I possibly damaging Het
Slx4 A T 16: 3,797,773 (GRCm39) I1537N probably damaging Het
Sorl1 G A 9: 41,915,401 (GRCm39) T1276M probably damaging Het
Specc1 C T 11: 62,042,739 (GRCm39) T872M probably benign Het
Speer4f1 T C 5: 17,684,500 (GRCm39) I176T probably damaging Het
Spint1 T C 2: 119,079,283 (GRCm39) I455T probably benign Het
Srp54a A G 12: 55,135,978 (GRCm39) probably null Het
Stoml3 T A 3: 53,414,875 (GRCm39) N222K probably damaging Het
Syce1 C A 7: 140,359,809 (GRCm39) L83F probably damaging Het
Tanc2 A T 11: 105,689,504 (GRCm39) D222V probably damaging Het
Tasor2 T C 13: 3,646,785 (GRCm39) E80G probably damaging Het
Thsd7a G A 6: 12,418,336 (GRCm39) S631L probably benign Het
Vmn2r73 G A 7: 85,507,144 (GRCm39) H723Y probably benign Het
Wdfy4 T C 14: 32,769,237 (GRCm39) E2076G probably damaging Het
Other mutations in Prdm15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00973:Prdm15 APN 16 97,607,367 (GRCm39) splice site probably benign
IGL01325:Prdm15 APN 16 97,607,717 (GRCm39) missense probably damaging 1.00
IGL02195:Prdm15 APN 16 97,637,029 (GRCm39) missense probably damaging 1.00
IGL02473:Prdm15 APN 16 97,638,805 (GRCm39) splice site probably null
IGL02502:Prdm15 APN 16 97,640,539 (GRCm39) missense probably damaging 1.00
IGL02604:Prdm15 APN 16 97,623,142 (GRCm39) missense probably benign
R0408:Prdm15 UTSW 16 97,636,986 (GRCm39) missense possibly damaging 0.92
R0437:Prdm15 UTSW 16 97,613,759 (GRCm39) missense probably benign 0.00
R0497:Prdm15 UTSW 16 97,595,534 (GRCm39) missense possibly damaging 0.63
R0590:Prdm15 UTSW 16 97,598,961 (GRCm39) missense possibly damaging 0.95
R0630:Prdm15 UTSW 16 97,638,907 (GRCm39) missense probably null 1.00
R0661:Prdm15 UTSW 16 97,630,882 (GRCm39) missense probably benign 0.34
R0718:Prdm15 UTSW 16 97,613,833 (GRCm39) missense possibly damaging 0.89
R1144:Prdm15 UTSW 16 97,609,908 (GRCm39) missense probably damaging 1.00
R1240:Prdm15 UTSW 16 97,638,800 (GRCm39) missense probably damaging 0.98
R1605:Prdm15 UTSW 16 97,640,506 (GRCm39) missense probably damaging 1.00
R1908:Prdm15 UTSW 16 97,638,885 (GRCm39) missense probably benign 0.27
R2081:Prdm15 UTSW 16 97,604,980 (GRCm39) nonsense probably null
R2208:Prdm15 UTSW 16 97,600,464 (GRCm39) splice site probably null
R3787:Prdm15 UTSW 16 97,598,945 (GRCm39) missense probably benign 0.00
R4326:Prdm15 UTSW 16 97,607,715 (GRCm39) missense probably damaging 1.00
R4728:Prdm15 UTSW 16 97,622,986 (GRCm39) missense probably benign 0.04
R4952:Prdm15 UTSW 16 97,607,277 (GRCm39) missense probably damaging 0.99
R4998:Prdm15 UTSW 16 97,595,689 (GRCm39) missense probably damaging 0.97
R5225:Prdm15 UTSW 16 97,609,875 (GRCm39) missense probably damaging 1.00
R5505:Prdm15 UTSW 16 97,618,183 (GRCm39) missense possibly damaging 0.76
R5628:Prdm15 UTSW 16 97,600,823 (GRCm39) missense probably damaging 0.98
R5721:Prdm15 UTSW 16 97,608,296 (GRCm39) missense possibly damaging 0.74
R5873:Prdm15 UTSW 16 97,609,889 (GRCm39) missense probably damaging 1.00
R5980:Prdm15 UTSW 16 97,613,770 (GRCm39) nonsense probably null
R6311:Prdm15 UTSW 16 97,600,255 (GRCm39) missense probably null 0.08
R6540:Prdm15 UTSW 16 97,637,005 (GRCm39) missense probably benign 0.13
R7053:Prdm15 UTSW 16 97,595,742 (GRCm39) nonsense probably null
R7241:Prdm15 UTSW 16 97,596,941 (GRCm39) missense possibly damaging 0.50
R7468:Prdm15 UTSW 16 97,636,842 (GRCm39) nonsense probably null
R7473:Prdm15 UTSW 16 97,623,046 (GRCm39) missense possibly damaging 0.68
R7762:Prdm15 UTSW 16 97,619,473 (GRCm39) missense probably benign 0.00
R7911:Prdm15 UTSW 16 97,613,792 (GRCm39) missense probably benign 0.35
R8053:Prdm15 UTSW 16 97,636,807 (GRCm39) missense probably benign 0.17
R8127:Prdm15 UTSW 16 97,638,910 (GRCm39) missense probably benign 0.24
R8213:Prdm15 UTSW 16 97,608,260 (GRCm39) missense probably damaging 1.00
R8708:Prdm15 UTSW 16 97,618,066 (GRCm39) missense unknown
R8768:Prdm15 UTSW 16 97,638,888 (GRCm39) missense probably benign
R9000:Prdm15 UTSW 16 97,595,470 (GRCm39) missense probably benign 0.03
R9513:Prdm15 UTSW 16 97,607,704 (GRCm39) missense probably damaging 1.00
R9583:Prdm15 UTSW 16 97,623,142 (GRCm39) missense probably benign
RF002:Prdm15 UTSW 16 97,600,829 (GRCm39) missense probably damaging 1.00
RF021:Prdm15 UTSW 16 97,609,956 (GRCm39) missense probably damaging 1.00
Z1177:Prdm15 UTSW 16 97,618,159 (GRCm39) missense possibly damaging 0.54
Predicted Primers PCR Primer
(F):5'- TTACTCATGGTCCTTGAAGAATGG -3'
(R):5'- GCCTAAATTTGAGGTCACAGTTTTC -3'

Sequencing Primer
(F):5'- TCATGGTCCTTGAAGAATGGACACTG -3'
(R):5'- TTGATTAATTTACCATTACCCTGAGG -3'
Posted On 2015-04-17