Incidental Mutation 'R3896:Or4c15b'
ID 310526
Institutional Source Beutler Lab
Gene Symbol Or4c15b
Ensembl Gene ENSMUSG00000075095
Gene Name olfactory receptor family 4 subfamily C member 15B
Synonyms Olfr1229, GA_x6K02T2Q125-50727797-50726862, MOR233-19, MOR233-22
MMRRC Submission 040807-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R3896 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89112540-89113475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 89113441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 33 (F33S)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099788] [ENSMUST00000213883] [ENSMUST00000214593]
AlphaFold Q7TQZ9
Predicted Effect possibly damaging
Transcript: ENSMUST00000099788
AA Change: F12S

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000097376
Gene: ENSMUSG00000075095
AA Change: F12S

DomainStartEndE-ValueType
Pfam:7tm_1 39 286 2.9e-29 PFAM
Pfam:7tm_4 138 279 1.7e-42 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000111549
AA Change: F33S

PolyPhen 2 Score 0.781 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000107174
Gene: ENSMUSG00000075095
AA Change: F33S

DomainStartEndE-ValueType
transmembrane domain 2 19 N/A INTRINSIC
Pfam:7tm_4 49 324 9.6e-51 PFAM
Pfam:7tm_1 60 307 7.3e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213883
AA Change: F12S

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214593
AA Change: F12S

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503B20Rik A T 3: 146,356,868 (GRCm39) N13K possibly damaging Het
Alas1 G T 9: 106,119,000 (GRCm39) probably null Het
Arhgap20 A T 9: 51,728,137 (GRCm39) I117F probably damaging Het
Asz1 A G 6: 18,075,766 (GRCm39) I269T probably benign Het
Atp8a2 C A 14: 60,263,589 (GRCm39) probably null Het
Atp8b2 A T 3: 89,864,626 (GRCm39) I163K probably damaging Het
Casd1 T A 6: 4,640,980 (GRCm39) F700L probably damaging Het
Ccdc80 A G 16: 44,916,984 (GRCm39) D580G probably benign Het
Cog7 C T 7: 121,540,392 (GRCm39) probably benign Het
Cyp2c66 T C 19: 39,130,722 (GRCm39) V112A possibly damaging Het
D130040H23Rik T A 8: 69,755,610 (GRCm39) C356S probably damaging Het
Emb A G 13: 117,409,598 (GRCm39) *331W probably null Het
Enpp3 A C 10: 24,653,847 (GRCm39) S703R possibly damaging Het
Fam13b T C 18: 34,596,008 (GRCm39) probably benign Het
Foxp1 T A 6: 99,052,897 (GRCm39) Q97L probably benign Het
Gdf10 A T 14: 33,656,438 (GRCm39) N467Y probably damaging Het
Gm29394 C T 15: 57,912,024 (GRCm39) probably benign Het
Gsn T C 2: 35,192,650 (GRCm39) S522P possibly damaging Het
Hydin T A 8: 111,235,711 (GRCm39) F1899I possibly damaging Het
Ints1 C A 5: 139,743,399 (GRCm39) E1658* probably null Het
Jakmip2 A T 18: 43,682,751 (GRCm39) F691Y probably benign Het
Klhl28 A G 12: 65,004,333 (GRCm39) F60S probably damaging Het
Loxhd1 C T 18: 77,469,719 (GRCm39) S992L possibly damaging Het
Lrp1b A T 2: 40,812,440 (GRCm39) probably null Het
Macf1 A T 4: 123,364,987 (GRCm39) I3258N possibly damaging Het
Map4k2 G T 19: 6,391,958 (GRCm39) E91* probably null Het
Matcap1 T A 8: 106,009,920 (GRCm39) H343L probably benign Het
Myo1b A T 1: 51,812,420 (GRCm39) V739E probably damaging Het
Naa35 C T 13: 59,755,109 (GRCm39) T185I probably damaging Het
Or10v9 T C 19: 11,832,951 (GRCm39) D122G probably damaging Het
Reg4 A T 3: 98,132,082 (GRCm39) probably benign Het
Rnaseh2b A C 14: 62,597,906 (GRCm39) probably benign Het
Rnf123 G A 9: 107,946,302 (GRCm39) probably benign Het
Scn8a A T 15: 100,933,379 (GRCm39) M1528L probably benign Het
Sdr16c5 T A 4: 4,006,609 (GRCm39) T228S probably damaging Het
Sgo2a T C 1: 58,052,805 (GRCm39) C202R probably damaging Het
Slc25a46 A G 18: 31,716,725 (GRCm39) L259P probably damaging Het
Slc4a4 A G 5: 89,345,625 (GRCm39) probably benign Het
Sox14 G T 9: 99,757,636 (GRCm39) H34Q probably damaging Het
Syna T A 5: 134,587,165 (GRCm39) K595* probably null Het
Taf4 A G 2: 179,573,807 (GRCm39) V687A probably benign Het
Tmbim7 C T 5: 3,711,916 (GRCm39) H54Y probably benign Het
Vmn1r212 T C 13: 23,068,067 (GRCm39) M89V probably benign Het
Vmn1r86 T C 7: 12,836,093 (GRCm39) Y261C probably benign Het
Xkr4 A G 1: 3,286,414 (GRCm39) I592T probably damaging Het
Ywhah A G 5: 33,184,349 (GRCm39) Y184C probably damaging Het
Zkscan16 C T 4: 58,946,125 (GRCm39) probably benign Het
Other mutations in Or4c15b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02982:Or4c15b APN 2 89,113,453 (GRCm39) missense probably damaging 0.98
R1535:Or4c15b UTSW 2 89,113,401 (GRCm39) missense probably benign 0.14
R1610:Or4c15b UTSW 2 89,113,165 (GRCm39) missense probably damaging 1.00
R4516:Or4c15b UTSW 2 89,113,187 (GRCm39) missense probably benign 0.05
R4922:Or4c15b UTSW 2 89,112,811 (GRCm39) missense possibly damaging 0.93
R4990:Or4c15b UTSW 2 89,113,671 (GRCm39) splice site probably null
R5267:Or4c15b UTSW 2 89,112,574 (GRCm39) nonsense probably null
R5271:Or4c15b UTSW 2 89,113,297 (GRCm39) missense probably benign 0.39
R5514:Or4c15b UTSW 2 89,112,817 (GRCm39) missense probably damaging 1.00
R5621:Or4c15b UTSW 2 89,112,697 (GRCm39) missense probably damaging 0.97
R7154:Or4c15b UTSW 2 89,113,204 (GRCm39) missense probably damaging 1.00
R7992:Or4c15b UTSW 2 89,113,082 (GRCm39) missense probably benign 0.01
R9028:Or4c15b UTSW 2 89,112,676 (GRCm39) missense probably damaging 1.00
Z1176:Or4c15b UTSW 2 89,113,241 (GRCm39) frame shift probably null
Z1176:Or4c15b UTSW 2 89,112,881 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CAGAGGAGAAGCTTGCATCC -3'
(R):5'- GACTATCACCTTGAAATGTTTCTGG -3'

Sequencing Primer
(F):5'- GCTTGCATCCAATAGAGACAAG -3'
(R):5'- TGTATTCTCAACAAAATCAGGCAC -3'
Posted On 2015-04-17