Incidental Mutation 'R3955:Tnip3'
ID 310641
Institutional Source Beutler Lab
Gene Symbol Tnip3
Ensembl Gene ENSMUSG00000044162
Gene Name TNFAIP3 interacting protein 3
Synonyms 9030611K07Rik
MMRRC Submission 040832-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3955 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 65567382-65611024 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 65574379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 137 (T137S)
Ref Sequence ENSEMBL: ENSMUSP00000148446 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114236] [ENSMUST00000212375] [ENSMUST00000212402]
AlphaFold A0A1D5RMN0
Predicted Effect probably benign
Transcript: ENSMUST00000114236
AA Change: T77S

PolyPhen 2 Score 0.128 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000109874
Gene: ENSMUSG00000044162
AA Change: T77S

DomainStartEndE-ValueType
coiled coil region 20 145 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204241
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204438
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205009
Predicted Effect possibly damaging
Transcript: ENSMUST00000212375
AA Change: T148S

PolyPhen 2 Score 0.484 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000212402
AA Change: T137S

PolyPhen 2 Score 0.484 (Sensitivity: 0.89; Specificity: 0.90)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.3%
Validation Efficiency 100% (56/56)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and do not develop spontaneous inflammatory or autoimmune disease; mutant macrophages exhibit normal responses to IL-10 and LPS. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,773,834 (GRCm39) T1008A probably benign Het
Abcc5 G C 16: 20,224,293 (GRCm39) H97D probably damaging Het
Acbd7 T C 2: 3,337,250 (GRCm39) S2P probably benign Het
Acta2 G T 19: 34,229,126 (GRCm39) probably benign Het
Adam2 G A 14: 66,295,059 (GRCm39) S262L probably damaging Het
Ajm1 G T 2: 25,467,583 (GRCm39) S776* probably null Het
Ccnq C A 11: 78,641,849 (GRCm39) E214* probably null Het
Cd69 A T 6: 129,245,343 (GRCm39) probably null Het
Cpsf3 A G 12: 21,363,806 (GRCm39) D632G probably benign Het
Dennd5a A G 7: 109,504,906 (GRCm39) M868T probably benign Het
Dscc1 T C 15: 54,946,949 (GRCm39) T259A probably benign Het
Dsg4 G A 18: 20,582,432 (GRCm39) probably null Het
Igfn1 A G 1: 135,894,918 (GRCm39) Y1883H possibly damaging Het
Insyn1 A T 9: 58,406,906 (GRCm39) D272V probably damaging Het
Krt20 G A 11: 99,323,037 (GRCm39) Q262* probably null Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Lmod2 G T 6: 24,603,870 (GRCm39) V282L probably benign Het
Lrrc49 A G 9: 60,578,642 (GRCm39) I228T probably damaging Het
Matn1 G A 4: 130,678,726 (GRCm39) probably null Het
Nek7 C A 1: 138,462,127 (GRCm39) C79F probably damaging Het
Nmt2 A G 2: 3,313,535 (GRCm39) D132G probably benign Het
Nup210l A T 3: 90,100,361 (GRCm39) R1462S possibly damaging Het
Obscn G A 11: 58,927,594 (GRCm39) S6118F probably damaging Het
Or14j6 A T 17: 38,214,500 (GRCm39) H21L probably benign Het
Or1j21 T A 2: 36,683,565 (GRCm39) L106M probably benign Het
Or4c12 T A 2: 89,774,172 (GRCm39) M96L possibly damaging Het
Or51f1 A G 7: 102,505,824 (GRCm39) C222R probably damaging Het
Or5al1 A G 2: 85,990,282 (GRCm39) V144A probably benign Het
Plxnb3 T C X: 72,814,826 (GRCm39) V1789A probably benign Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Qrfprl A T 6: 65,430,092 (GRCm39) I263L possibly damaging Het
Rab3gap1 A G 1: 127,862,254 (GRCm39) Q675R probably damaging Het
Rasgrf2 A G 13: 92,130,974 (GRCm39) S696P probably damaging Het
Sergef T A 7: 46,268,176 (GRCm39) E210V possibly damaging Het
Sik3 C A 9: 46,109,891 (GRCm39) N541K probably damaging Het
Slc26a1 T C 5: 108,821,448 (GRCm39) D147G possibly damaging Het
Tbc1d14 G A 5: 36,700,559 (GRCm39) R270* probably null Het
Tbc1d9 C T 8: 83,960,161 (GRCm39) T138I probably damaging Het
Tdp2 C T 13: 25,020,082 (GRCm39) T123I probably benign Het
Tec T C 5: 72,939,520 (GRCm39) probably null Het
Tmf1 C A 6: 97,153,167 (GRCm39) R302L probably damaging Het
Trim30d C T 7: 104,121,728 (GRCm39) G339D probably damaging Het
Tspan32 T A 7: 142,560,735 (GRCm39) M61K probably damaging Het
Ttc6 T C 12: 57,744,238 (GRCm39) V1290A probably benign Het
Ttn A G 2: 76,799,593 (GRCm39) V429A possibly damaging Het
Unc13b A G 4: 43,256,834 (GRCm39) Y3962C probably damaging Het
Vmn2r95 T A 17: 18,660,358 (GRCm39) Y257N possibly damaging Het
Zfp677 A G 17: 21,618,079 (GRCm39) K379E possibly damaging Het
Zfp865 T A 7: 5,035,013 (GRCm39) D999E probably damaging Het
Other mutations in Tnip3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01736:Tnip3 APN 6 65,573,107 (GRCm39) splice site probably benign
IGL02054:Tnip3 APN 6 65,567,595 (GRCm39) missense possibly damaging 0.72
IGL02382:Tnip3 APN 6 65,591,779 (GRCm39) critical splice donor site probably null
nickle_nip UTSW 6 65,591,779 (GRCm39) critical splice donor site probably null
R0671:Tnip3 UTSW 6 65,574,347 (GRCm39) missense probably damaging 1.00
R1344:Tnip3 UTSW 6 65,574,413 (GRCm39) missense probably benign 0.44
R1418:Tnip3 UTSW 6 65,574,413 (GRCm39) missense probably benign 0.44
R3748:Tnip3 UTSW 6 65,591,747 (GRCm39) missense probably damaging 0.99
R3953:Tnip3 UTSW 6 65,574,379 (GRCm39) missense possibly damaging 0.48
R5775:Tnip3 UTSW 6 65,591,741 (GRCm39) missense probably benign 0.01
R5930:Tnip3 UTSW 6 65,582,937 (GRCm39) missense probably damaging 1.00
R6108:Tnip3 UTSW 6 65,502,395 (GRCm39) splice site probably null
R6495:Tnip3 UTSW 6 65,582,846 (GRCm39) missense probably benign 0.05
R7210:Tnip3 UTSW 6 65,570,495 (GRCm39) nonsense probably null
R7956:Tnip3 UTSW 6 65,591,779 (GRCm39) critical splice donor site probably null
R7983:Tnip3 UTSW 6 65,515,630 (GRCm39) missense probably damaging 1.00
R8267:Tnip3 UTSW 6 65,582,826 (GRCm39) missense possibly damaging 0.77
R8957:Tnip3 UTSW 6 65,582,843 (GRCm39) missense probably benign 0.05
Z1177:Tnip3 UTSW 6 65,591,717 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- AGCGCCCTTTAAAATGCAAACG -3'
(R):5'- CTCTTTTCCTGGTCACTGGAGG -3'

Sequencing Primer
(F):5'- GCAAACGTGCCTACCTACAG -3'
(R):5'- TGGTCACTGGAGGCACGC -3'
Posted On 2015-04-29