Incidental Mutation 'R3956:Or5al5'
ID 310679
Institutional Source Beutler Lab
Gene Symbol Or5al5
Ensembl Gene ENSMUSG00000075204
Gene Name olfactory receptor family 5 subfamily AL member 5
Synonyms MOR185-5, Olfr1517, MOR185-5, MOR185-9P, Olfr1039, GA_x6K02T2Q125-47600809-47599850, MOR185-5
MMRRC Submission 040833-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R3956 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85961046-85962005 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85961363 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 215 (V215I)
Ref Sequence ENSEMBL: ENSMUSP00000149830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099910] [ENSMUST00000214364] [ENSMUST00000216566] [ENSMUST00000216665]
AlphaFold A2ARY0
Predicted Effect probably benign
Transcript: ENSMUST00000099910
AA Change: V215I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097494
Gene: ENSMUSG00000075204
AA Change: V215I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1e-50 PFAM
Pfam:7tm_1 41 290 2.4e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214364
AA Change: V215I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216566
AA Change: V215I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216665
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.5%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,100,805 (GRCm39) K393E possibly damaging Het
Aagab A G 9: 63,526,442 (GRCm39) E155G probably damaging Het
Abca16 A G 7: 120,126,975 (GRCm39) N1221S probably damaging Het
Acad11 A G 9: 103,963,351 (GRCm39) probably benign Het
Acsl1 T A 8: 46,987,495 (GRCm39) L693Q probably damaging Het
Adam2 G A 14: 66,295,059 (GRCm39) S262L probably damaging Het
B3gat1 A G 9: 26,668,324 (GRCm39) T305A possibly damaging Het
BC051076 A G 5: 88,112,110 (GRCm39) noncoding transcript Het
Ccni A G 5: 93,331,263 (GRCm39) L236S probably damaging Het
Ccnq C A 11: 78,641,849 (GRCm39) E214* probably null Het
Cdc45 A G 16: 18,624,180 (GRCm39) V119A probably benign Het
Clspn ACGGCGGCGGC A 4: 126,460,230 (GRCm39) probably null Het
Creld1 A G 6: 113,469,190 (GRCm39) D340G possibly damaging Het
Cyrib T C 15: 63,813,823 (GRCm39) Y158C probably damaging Het
Dipk1b C T 2: 26,525,579 (GRCm39) P171L probably benign Het
Dnah2 T A 11: 69,374,847 (GRCm39) I1417L probably benign Het
Efhc1 A C 1: 21,048,890 (GRCm39) K434N probably damaging Het
Evi5l T C 8: 4,241,358 (GRCm39) V297A possibly damaging Het
Fkbp8 T G 8: 70,987,517 (GRCm39) S376A probably damaging Het
Gfod1 A T 13: 43,354,538 (GRCm39) C146S probably damaging Het
Greb1 G T 12: 16,732,300 (GRCm39) P1554T probably damaging Het
Grip1 A T 10: 119,765,931 (GRCm39) I88F probably damaging Het
Hbq1a T C 11: 32,250,214 (GRCm39) probably null Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Kmt2e A G 5: 23,701,023 (GRCm39) T121A probably benign Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Mfsd2b A T 12: 4,916,848 (GRCm39) F194Y probably damaging Het
Mtmr3 A T 11: 4,441,138 (GRCm39) V504E probably damaging Het
Neb C T 2: 52,091,975 (GRCm39) V5030M possibly damaging Het
Nup210l A T 3: 90,100,361 (GRCm39) R1462S possibly damaging Het
Or5ac17 G A 16: 59,036,428 (GRCm39) Q183* probably null Het
Or5al1 A G 2: 85,990,282 (GRCm39) V144A probably benign Het
Pmfbp1 A G 8: 110,256,801 (GRCm39) S502G probably benign Het
Prb1c G T 6: 132,338,814 (GRCm39) Q135K unknown Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Qng1 A G 13: 58,532,203 (GRCm39) S118P probably damaging Het
Ralgapa2 C T 2: 146,277,884 (GRCm39) V426I probably damaging Het
Rasgrf2 A G 13: 92,130,974 (GRCm39) S696P probably damaging Het
Riok3 T A 18: 12,276,031 (GRCm39) Y242* probably null Het
Robo2 T G 16: 73,758,755 (GRCm39) Y672S probably damaging Het
Rsbn1 A G 3: 103,835,991 (GRCm39) H343R probably damaging Het
Sar1a A T 10: 61,522,172 (GRCm39) N88I possibly damaging Het
Sgcz A G 8: 37,993,346 (GRCm39) probably benign Het
Spmip9 A G 6: 70,890,469 (GRCm39) Y108H possibly damaging Het
Tbc1d9 C T 8: 83,960,161 (GRCm39) T138I probably damaging Het
Tlcd5 C A 9: 43,022,808 (GRCm39) C182F probably damaging Het
Tmem131l C A 3: 83,817,726 (GRCm39) C1257F probably damaging Het
Top6bl T A 19: 4,742,525 (GRCm39) T214S probably benign Het
Ttn A G 2: 76,799,593 (GRCm39) V429A possibly damaging Het
Umodl1 A G 17: 31,221,837 (GRCm39) T1280A probably benign Het
Xpnpep3 A G 15: 81,335,230 (GRCm39) probably benign Het
Other mutations in Or5al5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Or5al5 APN 2 85,962,012 (GRCm39) utr 5 prime probably benign
IGL01981:Or5al5 APN 2 85,961,174 (GRCm39) missense probably benign 0.44
IGL02958:Or5al5 APN 2 85,961,351 (GRCm39) missense probably benign 0.00
R0645:Or5al5 UTSW 2 85,961,378 (GRCm39) missense probably damaging 1.00
R1052:Or5al5 UTSW 2 85,961,915 (GRCm39) missense probably benign 0.13
R1613:Or5al5 UTSW 2 85,961,407 (GRCm39) missense probably damaging 1.00
R2132:Or5al5 UTSW 2 85,961,605 (GRCm39) missense possibly damaging 0.52
R6372:Or5al5 UTSW 2 85,961,198 (GRCm39) missense possibly damaging 0.50
R7338:Or5al5 UTSW 2 85,961,726 (GRCm39) missense probably damaging 0.99
R7514:Or5al5 UTSW 2 85,961,972 (GRCm39) missense probably damaging 1.00
R7535:Or5al5 UTSW 2 85,961,608 (GRCm39) missense probably benign 0.00
R7537:Or5al5 UTSW 2 85,961,608 (GRCm39) missense probably benign 0.00
R8052:Or5al5 UTSW 2 85,961,721 (GRCm39) nonsense probably null
R9736:Or5al5 UTSW 2 85,961,640 (GRCm39) missense probably damaging 1.00
RF005:Or5al5 UTSW 2 85,961,414 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CAGCGGATTTAACATGGGAATTACTAC -3'
(R):5'- ATTCACTGTGGGGCTTGCAC -3'

Sequencing Primer
(F):5'- ATGGGAATTACTACCACGTAAAAC -3'
(R):5'- ACAGGCAGTGGCAACTTTC -3'
Posted On 2015-04-29