Incidental Mutation 'R3971:Chrnb1'
ID |
310983 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Chrnb1
|
Ensembl Gene |
ENSMUSG00000041189 |
Gene Name |
cholinergic receptor nicotinic beta 1 subunit |
Synonyms |
Acrb, Achr-2, AChR beta |
MMRRC Submission |
040839-MU
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.871)
|
Stock # |
R3971 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
69674862-69686742 bp(-) (GRCm39) |
Type of Mutation |
unclassified |
DNA Base Change (assembly) |
A to G
at 69683742 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000099645
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000011285]
[ENSMUST00000045971]
[ENSMUST00000102585]
|
AlphaFold |
P09690 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000011285
|
SMART Domains |
Protein: ENSMUSP00000011285 Gene: ENSMUSG00000042826
Domain | Start | End | E-Value | Type |
FGF
|
69 |
172 |
6.95e-35 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000045971
|
SMART Domains |
Protein: ENSMUSP00000047270 Gene: ENSMUSG00000041189
Domain | Start | End | E-Value | Type |
low complexity region
|
2 |
21 |
N/A |
INTRINSIC |
Pfam:Neur_chan_LBD
|
27 |
245 |
3.6e-65 |
PFAM |
Pfam:Neur_chan_memb
|
252 |
487 |
3.5e-75 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000102585
|
SMART Domains |
Protein: ENSMUSP00000099645 Gene: ENSMUSG00000042826
Domain | Start | End | E-Value | Type |
FGF
|
69 |
200 |
3.43e-66 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129381
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147791
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154816
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.3%
|
Validation Efficiency |
95% (38/40) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a knock-in allele lack all tyrosine residues in the beta subunit intracellular loop, display reduced and simplified neuromuscular junctions, and show defective acetylcholine receptor clustering and anchoring at synapses. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadat |
C |
T |
8: 60,971,615 (GRCm39) |
P147L |
probably damaging |
Het |
Apbb1ip |
T |
A |
2: 22,713,506 (GRCm39) |
D120E |
unknown |
Het |
Atp10b |
A |
G |
11: 43,107,339 (GRCm39) |
D791G |
probably damaging |
Het |
Aunip |
A |
G |
4: 134,250,780 (GRCm39) |
K242E |
possibly damaging |
Het |
Ccdc80 |
A |
G |
16: 44,916,183 (GRCm39) |
E313G |
probably benign |
Het |
Cd72 |
C |
T |
4: 43,449,491 (GRCm39) |
R275H |
probably damaging |
Het |
Coro2b |
C |
T |
9: 62,336,522 (GRCm39) |
A251T |
possibly damaging |
Het |
Cspg4b |
A |
G |
13: 113,453,660 (GRCm39) |
E41G |
probably damaging |
Het |
Ddr2 |
A |
G |
1: 169,815,986 (GRCm39) |
F574L |
probably damaging |
Het |
Dock1 |
G |
A |
7: 134,348,637 (GRCm39) |
D284N |
probably damaging |
Het |
Dync1h1 |
A |
G |
12: 110,632,399 (GRCm39) |
H4506R |
probably benign |
Het |
Fam174b |
T |
C |
7: 73,416,348 (GRCm39) |
V147A |
probably damaging |
Het |
Glp2r |
T |
A |
11: 67,637,641 (GRCm39) |
D130V |
possibly damaging |
Het |
Gm18856 |
A |
T |
13: 14,139,433 (GRCm39) |
|
probably benign |
Het |
Gm7247 |
A |
G |
14: 51,602,841 (GRCm39) |
Y59C |
probably damaging |
Het |
Hecw1 |
T |
C |
13: 14,411,514 (GRCm39) |
D1062G |
probably damaging |
Het |
Ifit2 |
A |
G |
19: 34,551,441 (GRCm39) |
E327G |
probably benign |
Het |
Ighv1-37 |
A |
T |
12: 114,860,079 (GRCm39) |
S43T |
probably damaging |
Het |
Man2b1 |
A |
G |
8: 85,812,020 (GRCm39) |
N158S |
probably damaging |
Het |
Mcoln1 |
T |
A |
8: 3,557,408 (GRCm39) |
I138K |
probably benign |
Het |
Mki67 |
A |
C |
7: 135,297,859 (GRCm39) |
S2392A |
probably benign |
Het |
Mrc2 |
G |
A |
11: 105,218,857 (GRCm39) |
D193N |
possibly damaging |
Het |
Myo5b |
C |
T |
18: 74,873,598 (GRCm39) |
L1501F |
probably damaging |
Het |
Nckap1l |
A |
G |
15: 103,370,987 (GRCm39) |
K189E |
probably damaging |
Het |
Obscn |
T |
C |
11: 59,022,472 (GRCm39) |
R758G |
possibly damaging |
Het |
Or6c69 |
T |
C |
10: 129,747,742 (GRCm39) |
N135S |
probably benign |
Het |
Otop1 |
A |
G |
5: 38,457,533 (GRCm39) |
I431V |
probably benign |
Het |
Psma8 |
A |
G |
18: 14,890,444 (GRCm39) |
K195E |
possibly damaging |
Het |
Rbm25 |
A |
G |
12: 83,721,982 (GRCm39) |
T723A |
probably benign |
Het |
Sema3b |
A |
G |
9: 107,477,567 (GRCm39) |
S485P |
probably benign |
Het |
Slc12a2 |
T |
A |
18: 58,063,268 (GRCm39) |
L916Q |
possibly damaging |
Het |
Spata31d1a |
T |
A |
13: 59,849,971 (GRCm39) |
D719V |
possibly damaging |
Het |
Synj1 |
A |
G |
16: 90,788,491 (GRCm39) |
S86P |
probably damaging |
Het |
Tmem130 |
T |
A |
5: 144,692,131 (GRCm39) |
H91L |
probably benign |
Het |
Tsc2 |
T |
C |
17: 24,842,562 (GRCm39) |
D288G |
probably damaging |
Het |
Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
Vps35l |
T |
C |
7: 118,433,022 (GRCm39) |
I585T |
probably damaging |
Het |
Wac |
T |
C |
18: 7,916,175 (GRCm39) |
V303A |
probably damaging |
Het |
Zfhx2 |
A |
G |
14: 55,311,932 (GRCm39) |
V254A |
probably benign |
Het |
Zfp993 |
A |
G |
4: 146,742,089 (GRCm39) |
T138A |
probably benign |
Het |
|
Other mutations in Chrnb1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00585:Chrnb1
|
APN |
11 |
69,684,742 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01924:Chrnb1
|
APN |
11 |
69,685,845 (GRCm39) |
unclassified |
probably benign |
|
IGL01983:Chrnb1
|
APN |
11 |
69,686,555 (GRCm39) |
missense |
probably benign |
0.27 |
IGL02100:Chrnb1
|
APN |
11 |
69,684,281 (GRCm39) |
unclassified |
probably benign |
|
IGL02507:Chrnb1
|
APN |
11 |
69,675,916 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02814:Chrnb1
|
APN |
11 |
69,686,506 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02858:Chrnb1
|
APN |
11 |
69,675,935 (GRCm39) |
missense |
possibly damaging |
0.58 |
R0368:Chrnb1
|
UTSW |
11 |
69,675,583 (GRCm39) |
missense |
probably damaging |
1.00 |
R1728:Chrnb1
|
UTSW |
11 |
69,676,588 (GRCm39) |
missense |
probably damaging |
1.00 |
R1913:Chrnb1
|
UTSW |
11 |
69,684,410 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1930:Chrnb1
|
UTSW |
11 |
69,683,563 (GRCm39) |
missense |
possibly damaging |
0.81 |
R2233:Chrnb1
|
UTSW |
11 |
69,686,428 (GRCm39) |
missense |
probably damaging |
0.98 |
R2234:Chrnb1
|
UTSW |
11 |
69,686,428 (GRCm39) |
missense |
probably damaging |
0.98 |
R4183:Chrnb1
|
UTSW |
11 |
69,677,922 (GRCm39) |
missense |
possibly damaging |
0.50 |
R4425:Chrnb1
|
UTSW |
11 |
69,677,773 (GRCm39) |
missense |
probably damaging |
1.00 |
R4822:Chrnb1
|
UTSW |
11 |
69,686,501 (GRCm39) |
missense |
possibly damaging |
0.55 |
R4983:Chrnb1
|
UTSW |
11 |
69,684,804 (GRCm39) |
missense |
probably damaging |
1.00 |
R5000:Chrnb1
|
UTSW |
11 |
69,677,858 (GRCm39) |
missense |
probably damaging |
0.96 |
R5378:Chrnb1
|
UTSW |
11 |
69,676,007 (GRCm39) |
missense |
probably benign |
0.00 |
R5396:Chrnb1
|
UTSW |
11 |
69,684,979 (GRCm39) |
missense |
probably damaging |
1.00 |
R5540:Chrnb1
|
UTSW |
11 |
69,686,476 (GRCm39) |
missense |
probably benign |
0.30 |
R5574:Chrnb1
|
UTSW |
11 |
69,684,509 (GRCm39) |
unclassified |
probably benign |
|
R5890:Chrnb1
|
UTSW |
11 |
69,683,555 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5973:Chrnb1
|
UTSW |
11 |
69,686,671 (GRCm39) |
unclassified |
probably benign |
|
R6056:Chrnb1
|
UTSW |
11 |
69,677,765 (GRCm39) |
missense |
probably damaging |
1.00 |
R7466:Chrnb1
|
UTSW |
11 |
69,675,476 (GRCm39) |
missense |
probably damaging |
1.00 |
R7633:Chrnb1
|
UTSW |
11 |
69,683,699 (GRCm39) |
missense |
probably damaging |
1.00 |
R7664:Chrnb1
|
UTSW |
11 |
69,677,850 (GRCm39) |
missense |
possibly damaging |
0.80 |
R8266:Chrnb1
|
UTSW |
11 |
69,675,447 (GRCm39) |
makesense |
probably null |
|
R9124:Chrnb1
|
UTSW |
11 |
69,685,057 (GRCm39) |
missense |
probably benign |
0.31 |
Z1177:Chrnb1
|
UTSW |
11 |
69,685,015 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Predicted Primers |
PCR Primer
(F):5'- TTACCTGCATCTGGTGGGAG -3'
(R):5'- GTCAGCAACTTGGGGATGATG -3'
Sequencing Primer
(F):5'- TGGCCAGGAGCGTGATG -3'
(R):5'- TGAATTCAGTCCCGGGAATC -3'
|
Posted On |
2015-04-29 |