Incidental Mutation 'R3977:Or4c3'
ID 311058
Institutional Source Beutler Lab
Gene Symbol Or4c3
Ensembl Gene ENSMUSG00000075069
Gene Name olfactory receptor family 4 subfamily C member 3
Synonyms MOR236-1, GA_x6K02T2Q125-51454183-51453257, Olfr1264
MMRRC Submission 040940-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.334) question?
Stock # R3977 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89851482-89852408 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 89852089 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Valine at position 107 (G107V)
Ref Sequence ENSEMBL: ENSMUSP00000149126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099758] [ENSMUST00000214382] [ENSMUST00000216616] [ENSMUST00000217065]
AlphaFold Q9R0K2
Predicted Effect probably damaging
Transcript: ENSMUST00000099758
AA Change: G107V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097347
Gene: ENSMUSG00000075069
AA Change: G107V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.8e-47 PFAM
Pfam:7tm_1 39 285 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214382
Predicted Effect probably damaging
Transcript: ENSMUST00000216616
AA Change: G107V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216764
Predicted Effect probably benign
Transcript: ENSMUST00000217065
Meta Mutation Damage Score 0.2128 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace C T 11: 105,872,664 (GRCm39) P942L possibly damaging Het
Adam28 A G 14: 68,848,443 (GRCm39) V671A probably benign Het
Arfgef1 A G 1: 10,279,859 (GRCm39) V236A probably benign Het
B020004C17Rik G T 14: 57,254,645 (GRCm39) M156I possibly damaging Het
Bicral T A 17: 47,141,917 (GRCm39) M1L unknown Het
Brpf3 A G 17: 29,026,016 (GRCm39) E363G possibly damaging Het
Ccdc96 T C 5: 36,642,510 (GRCm39) L172P possibly damaging Het
Cln3 G A 7: 126,179,308 (GRCm39) probably benign Het
Dnah7c T C 1: 46,668,071 (GRCm39) I1526T possibly damaging Het
Entr1 T A 2: 26,274,805 (GRCm39) N364I probably damaging Het
Fmo3 T G 1: 162,786,147 (GRCm39) E281A probably damaging Het
Frem2 A G 3: 53,559,491 (GRCm39) I1672T probably benign Het
Gbp2b A G 3: 142,309,470 (GRCm39) I194V probably benign Het
Gprc6a C A 10: 51,497,197 (GRCm39) V449L probably benign Het
Hk1 A G 10: 62,126,098 (GRCm39) V396A probably benign Het
Hoxc13 T C 15: 102,829,675 (GRCm39) V18A possibly damaging Het
Hr A G 14: 70,801,024 (GRCm39) T699A probably benign Het
Il19 A T 1: 130,863,770 (GRCm39) C74S probably damaging Het
Krt1c T C 15: 101,719,562 (GRCm39) T703A unknown Het
Lrig2 A T 3: 104,365,160 (GRCm39) V664E probably damaging Het
Lrrc37a T C 11: 103,348,430 (GRCm39) K2755R unknown Het
Man1c1 G C 4: 134,430,749 (GRCm39) P11R probably damaging Het
Mbtd1 A G 11: 93,796,001 (GRCm39) N13D probably benign Het
Mfsd4b5 T C 10: 39,850,704 (GRCm39) probably benign Het
Nras A G 3: 102,967,541 (GRCm39) I46V probably benign Het
Oasl1 C T 5: 115,070,957 (GRCm39) T274I probably damaging Het
Ogfod2 C A 5: 124,251,272 (GRCm39) probably null Het
Or10q3 C A 19: 11,847,869 (GRCm39) R237L possibly damaging Het
Or10v1 T A 19: 11,873,880 (GRCm39) F165Y probably damaging Het
Or11a4 T C 17: 37,536,049 (GRCm39) V11A probably benign Het
Or2w1b T A 13: 21,300,031 (GRCm39) H56Q probably benign Het
Or6c5 C T 10: 129,074,377 (GRCm39) R120C probably damaging Het
Pkmyt1 A G 17: 23,954,305 (GRCm39) M362V probably benign Het
Ppfia2 A G 10: 106,666,490 (GRCm39) T399A possibly damaging Het
Ppp1r12b A G 1: 134,693,713 (GRCm39) S983P probably benign Het
Ptpn22 A G 3: 103,780,957 (GRCm39) probably benign Het
Raph1 A T 1: 60,537,682 (GRCm39) D491E probably benign Het
Rc3h1 A G 1: 160,786,969 (GRCm39) probably null Het
Rtn4 T C 11: 29,643,819 (GRCm39) L5P probably benign Het
Slc23a4 C T 6: 34,930,723 (GRCm39) V400I probably benign Het
Slco1a5 A G 6: 142,204,698 (GRCm39) probably benign Het
Smpd1 T C 7: 105,205,108 (GRCm39) F329S probably benign Het
Sycp2l A G 13: 41,295,440 (GRCm39) I334M probably damaging Het
Tas2r103 A G 6: 133,013,280 (GRCm39) L262P probably benign Het
Ten1 G A 11: 116,107,771 (GRCm39) probably null Het
Tfap2d C G 1: 19,174,718 (GRCm39) S57C possibly damaging Het
Tnr A G 1: 159,719,593 (GRCm39) M957V probably benign Het
Trbv13-3 A G 6: 41,107,079 (GRCm39) probably benign Het
Trp53rkb C T 2: 166,637,446 (GRCm39) A134V possibly damaging Het
Trp63 A G 16: 25,639,490 (GRCm39) probably benign Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r74 T C 7: 85,607,345 (GRCm39) Y126C probably benign Het
Vmn2r96 T A 17: 18,817,941 (GRCm39) I698N probably damaging Het
Other mutations in Or4c3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1635:Or4c3 UTSW 2 89,852,314 (GRCm39) missense possibly damaging 0.94
R1758:Or4c3 UTSW 2 89,851,673 (GRCm39) missense probably benign
R1930:Or4c3 UTSW 2 89,851,505 (GRCm39) missense probably benign
R2159:Or4c3 UTSW 2 89,851,882 (GRCm39) missense probably damaging 0.97
R4028:Or4c3 UTSW 2 89,851,567 (GRCm39) missense probably damaging 1.00
R4884:Or4c3 UTSW 2 89,851,987 (GRCm39) missense probably benign 0.19
R5194:Or4c3 UTSW 2 89,851,870 (GRCm39) missense probably damaging 1.00
R5225:Or4c3 UTSW 2 89,851,528 (GRCm39) missense probably benign 0.00
R5399:Or4c3 UTSW 2 89,852,267 (GRCm39) missense probably benign 0.19
R5436:Or4c3 UTSW 2 89,852,009 (GRCm39) missense probably benign 0.25
R5753:Or4c3 UTSW 2 89,851,847 (GRCm39) missense possibly damaging 0.87
R6225:Or4c3 UTSW 2 89,851,573 (GRCm39) splice site probably null
R6391:Or4c3 UTSW 2 89,851,975 (GRCm39) missense probably benign 0.03
R6531:Or4c3 UTSW 2 89,851,801 (GRCm39) missense probably benign 0.03
R7293:Or4c3 UTSW 2 89,851,871 (GRCm39) missense probably damaging 1.00
R7880:Or4c3 UTSW 2 89,852,381 (GRCm39) missense probably damaging 1.00
R8014:Or4c3 UTSW 2 89,852,087 (GRCm39) missense possibly damaging 0.95
R8887:Or4c3 UTSW 2 89,852,269 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TTACATTGGGTCCACAGAAAGG -3'
(R):5'- GGCAACATGCTCATTGTGGTC -3'

Sequencing Primer
(F):5'- GGCAACTGAAAAATCAGAAGGATC -3'
(R):5'- AACATGCTCATTGTGGTCACTGTC -3'
Posted On 2015-04-29