Incidental Mutation 'R3979:Or2w1b'
ID 311202
Institutional Source Beutler Lab
Gene Symbol Or2w1b
Ensembl Gene ENSMUSG00000060404
Gene Name olfactory receptor family 2 subfamily W member 1B
Synonyms Olfr1369, MOR256-31, GA_x6K02T2QHY8-12126170-12125935
MMRRC Submission 040942-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.346) question?
Stock # R3979 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21299764-21300871 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21300031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 56 (H56Q)
Ref Sequence ENSEMBL: ENSMUSP00000151041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079050] [ENSMUST00000213326] [ENSMUST00000213922] [ENSMUST00000215207] [ENSMUST00000215941]
AlphaFold A0A140T8K7
Predicted Effect probably benign
Transcript: ENSMUST00000079050
AA Change: H56Q

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000078059
Gene: ENSMUSG00000060404
AA Change: H56Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-47 PFAM
Pfam:7tm_1 41 290 1.1e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213326
AA Change: H56Q

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000213922
AA Change: H56Q

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000215207
AA Change: H56Q

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000215941
AA Change: H56Q

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A G 2: 69,154,320 (GRCm39) V82A probably benign Het
Adam28 A G 14: 68,848,443 (GRCm39) V671A probably benign Het
Ak3 T A 19: 29,025,118 (GRCm39) S38C probably damaging Het
Arfgef1 A G 1: 10,279,859 (GRCm39) V236A probably benign Het
Arhgap10 T C 8: 78,147,354 (GRCm39) N170S probably benign Het
B020004C17Rik G T 14: 57,254,645 (GRCm39) M156I possibly damaging Het
Bicral T A 17: 47,141,917 (GRCm39) M1L unknown Het
Bop1 A G 15: 76,338,076 (GRCm39) L598P probably damaging Het
Cachd1 A T 4: 100,828,085 (GRCm39) D611V probably damaging Het
Cfap70 T A 14: 20,489,787 (GRCm39) E246D probably benign Het
Chl1 T A 6: 103,692,245 (GRCm39) Y294* probably null Het
Chrna2 T A 14: 66,386,402 (GRCm39) Y183N probably damaging Het
Dab2 A G 15: 6,464,644 (GRCm39) probably null Het
Dnajb6 T C 5: 29,956,006 (GRCm39) F46L possibly damaging Het
Exoc7 T C 11: 116,187,588 (GRCm39) E275G probably benign Het
Frem2 A G 3: 53,559,491 (GRCm39) I1672T probably benign Het
Gprc6a C A 10: 51,497,197 (GRCm39) V449L probably benign Het
H2-M10.4 A G 17: 36,772,877 (GRCm39) V35A probably benign Het
Hr A G 14: 70,801,024 (GRCm39) T699A probably benign Het
Iffo1 A G 6: 125,137,552 (GRCm39) probably benign Het
Iqgap1 G A 7: 80,409,682 (GRCm39) H218Y probably damaging Het
Itpr3 A C 17: 27,304,105 (GRCm39) K109Q probably benign Het
Itpr3 A G 17: 27,310,546 (GRCm39) D443G probably damaging Het
Katna1 T C 10: 7,628,518 (GRCm39) M249T probably damaging Het
Klk1b4 G A 7: 43,861,017 (GRCm39) G220D probably damaging Het
Krt24 A G 11: 99,173,596 (GRCm39) C242R probably benign Het
Madd G A 2: 91,007,173 (GRCm39) T313I possibly damaging Het
Man1c1 G C 4: 134,430,749 (GRCm39) P11R probably damaging Het
Mical2 A G 7: 112,006,885 (GRCm39) probably null Het
Neil3 T C 8: 54,076,699 (GRCm39) T79A probably damaging Het
Nras A G 3: 102,967,541 (GRCm39) I46V probably benign Het
Or4a66 T C 2: 88,530,792 (GRCm39) S294G probably benign Het
Ppfia2 A G 10: 106,666,490 (GRCm39) T399A possibly damaging Het
Rarres1 A G 3: 67,403,143 (GRCm39) V86A probably benign Het
Rdh19 A T 10: 127,685,944 (GRCm39) R19W possibly damaging Het
Rock2 A G 12: 17,022,737 (GRCm39) K1059E probably damaging Het
Sft2d1rt T A 11: 45,942,853 (GRCm39) K90M probably damaging Het
Sparcl1 T C 5: 104,240,647 (GRCm39) H259R probably benign Het
Spata31d1c A G 13: 65,182,974 (GRCm39) D172G possibly damaging Het
Stab2 T C 10: 86,699,320 (GRCm39) D515G possibly damaging Het
Sycp2l A G 13: 41,295,440 (GRCm39) I334M probably damaging Het
Tas2r103 A G 6: 133,013,280 (GRCm39) L262P probably benign Het
Tasor T C 14: 27,199,087 (GRCm39) L1335S possibly damaging Het
Tcaf2 A G 6: 42,619,481 (GRCm39) V182A probably damaging Het
Tcof1 C T 18: 60,964,605 (GRCm39) E674K possibly damaging Het
Trp63 A G 16: 25,639,490 (GRCm39) probably benign Het
Ttn A T 2: 76,575,738 (GRCm39) W25052R probably damaging Het
Ubr1 T A 2: 120,693,168 (GRCm39) N1746I probably benign Het
Vax2 T C 6: 83,714,529 (GRCm39) V148A probably damaging Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r96 T A 17: 18,817,941 (GRCm39) I698N probably damaging Het
Wdr90 A G 17: 26,078,252 (GRCm39) V372A probably benign Het
Zfp335 C T 2: 164,752,558 (GRCm39) G62D probably benign Het
Zfp563 G A 17: 33,324,701 (GRCm39) R432H probably benign Het
Zhx1 T C 15: 57,916,636 (GRCm39) T537A probably benign Het
Other mutations in Or2w1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01689:Or2w1b APN 13 21,300,243 (GRCm39) missense probably damaging 0.97
R0631:Or2w1b UTSW 13 21,300,078 (GRCm39) missense probably damaging 1.00
R0960:Or2w1b UTSW 13 21,300,435 (GRCm39) missense possibly damaging 0.94
R1499:Or2w1b UTSW 13 21,300,303 (GRCm39) missense probably benign 0.32
R1549:Or2w1b UTSW 13 21,300,288 (GRCm39) missense probably benign 0.01
R1698:Or2w1b UTSW 13 21,300,735 (GRCm39) missense probably benign 0.11
R1711:Or2w1b UTSW 13 21,300,476 (GRCm39) missense probably benign 0.01
R2404:Or2w1b UTSW 13 21,300,012 (GRCm39) missense probably damaging 1.00
R2471:Or2w1b UTSW 13 21,300,599 (GRCm39) missense probably damaging 1.00
R3844:Or2w1b UTSW 13 21,300,233 (GRCm39) missense possibly damaging 0.91
R3977:Or2w1b UTSW 13 21,300,031 (GRCm39) missense probably benign 0.03
R4804:Or2w1b UTSW 13 21,300,175 (GRCm39) nonsense probably null
R4914:Or2w1b UTSW 13 21,300,567 (GRCm39) missense probably benign 0.12
R5210:Or2w1b UTSW 13 21,300,222 (GRCm39) missense probably damaging 0.99
R5359:Or2w1b UTSW 13 21,300,437 (GRCm39) missense probably damaging 1.00
R5700:Or2w1b UTSW 13 21,300,171 (GRCm39) missense probably damaging 1.00
R6218:Or2w1b UTSW 13 21,300,401 (GRCm39) missense probably damaging 1.00
R6767:Or2w1b UTSW 13 21,300,227 (GRCm39) missense probably benign 0.02
R7396:Or2w1b UTSW 13 21,300,477 (GRCm39) missense probably benign 0.02
R7476:Or2w1b UTSW 13 21,300,191 (GRCm39) missense probably benign 0.04
R7612:Or2w1b UTSW 13 21,300,217 (GRCm39) missense probably damaging 0.99
R8257:Or2w1b UTSW 13 21,300,543 (GRCm39) missense probably benign 0.11
R9388:Or2w1b UTSW 13 21,300,774 (GRCm39) missense probably damaging 0.96
R9697:Or2w1b UTSW 13 21,299,892 (GRCm39) missense probably benign 0.21
V8831:Or2w1b UTSW 13 21,300,173 (GRCm39) missense possibly damaging 0.93
Z1176:Or2w1b UTSW 13 21,300,771 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAAAGACTATGGACCCAAGC -3'
(R):5'- TGCAAGGGCTTACAAATAGCTG -3'

Sequencing Primer
(F):5'- GGACCCAAGCAATTACAGTACTTTG -3'
(R):5'- GGCTTACAAATAGCTGTGAAACGATC -3'
Posted On 2015-04-29