Incidental Mutation 'R4004:Or2t35'
| ID |
311404 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or2t35
|
| Ensembl Gene |
ENSMUSG00000091809 |
| Gene Name |
olfactory receptor family 2 subfamily T member 35 |
| Synonyms |
MOR274-3P, Olfr721, GA_x6K02T2PLTE-6793523-6794528, MOR274-4_i |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.077)
|
| Stock # |
R4004 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
8061565-8062539 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 14408152 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 308
(A308V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150661
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165291]
[ENSMUST00000206688]
[ENSMUST00000215479]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165291
AA Change: A310V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000133126
Gene: ENSMUSG00000091809
AA Change: A310V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
32 |
309 |
2.6e-46 |
PFAM |
|
Pfam:7tm_1
|
42 |
291 |
9.2e-24 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206688
AA Change: A308V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000215479
AA Change: A308V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acan |
A |
C |
7: 78,750,435 (GRCm39) |
E1735D |
probably damaging |
Het |
| Ano2 |
A |
G |
6: 125,990,242 (GRCm39) |
R788G |
probably damaging |
Het |
| Atg9a |
T |
C |
1: 75,163,095 (GRCm39) |
Y335C |
probably damaging |
Het |
| Capn10 |
T |
A |
1: 92,868,313 (GRCm39) |
L260Q |
probably damaging |
Het |
| Cblif |
T |
G |
19: 11,736,371 (GRCm39) |
V314G |
probably damaging |
Het |
| Ces1d |
A |
T |
8: 93,904,720 (GRCm39) |
F340Y |
probably benign |
Het |
| Cspg4b |
A |
G |
13: 113,454,914 (GRCm39) |
Q320R |
probably benign |
Het |
| Ctbp2 |
C |
A |
7: 132,593,502 (GRCm39) |
R733L |
probably benign |
Het |
| Dgkd |
T |
C |
1: 87,863,145 (GRCm39) |
I64T |
possibly damaging |
Het |
| Dmxl2 |
T |
C |
9: 54,353,674 (GRCm39) |
I765V |
probably benign |
Het |
| Dync2h1 |
C |
A |
9: 7,117,404 (GRCm39) |
C62F |
probably damaging |
Het |
| F2 |
T |
C |
2: 91,458,741 (GRCm39) |
N523S |
possibly damaging |
Het |
| Fat3 |
G |
A |
9: 15,909,567 (GRCm39) |
S2145F |
probably damaging |
Het |
| Fcgr1 |
A |
G |
3: 96,191,668 (GRCm39) |
V380A |
probably benign |
Het |
| Herc2 |
C |
A |
7: 55,756,213 (GRCm39) |
P751Q |
possibly damaging |
Het |
| Ikzf3 |
C |
T |
11: 98,379,843 (GRCm39) |
E142K |
probably damaging |
Het |
| Kctd3 |
A |
G |
1: 188,724,940 (GRCm39) |
S214P |
probably benign |
Het |
| Lrpap1 |
T |
A |
5: 35,262,888 (GRCm39) |
K50* |
probably null |
Het |
| Naa11 |
A |
T |
5: 97,539,652 (GRCm39) |
Y169N |
probably benign |
Het |
| Nup42 |
T |
C |
5: 24,387,434 (GRCm39) |
I408T |
probably damaging |
Het |
| Or1af1 |
A |
T |
2: 37,109,960 (GRCm39) |
H153L |
probably benign |
Het |
| Plxnc1 |
G |
A |
10: 94,630,459 (GRCm39) |
Q1512* |
probably null |
Het |
| Ptpn14 |
A |
G |
1: 189,582,707 (GRCm39) |
N518S |
probably benign |
Het |
| Rapgef5 |
A |
G |
12: 117,712,132 (GRCm39) |
I740V |
probably damaging |
Het |
| Ric1 |
C |
T |
19: 29,557,201 (GRCm39) |
R429C |
probably benign |
Het |
| Rpn2 |
T |
C |
2: 157,159,928 (GRCm39) |
L548P |
probably damaging |
Het |
| Ryr3 |
C |
G |
2: 112,506,218 (GRCm39) |
R3443P |
probably damaging |
Het |
| Slc28a1 |
T |
C |
7: 80,818,786 (GRCm39) |
S580P |
probably damaging |
Het |
| Slco6c1 |
A |
G |
1: 97,003,610 (GRCm39) |
Y496H |
probably damaging |
Het |
| Spag5 |
T |
C |
11: 78,212,355 (GRCm39) |
M1101T |
probably benign |
Het |
| Utp11 |
A |
T |
4: 124,576,230 (GRCm39) |
F138I |
probably damaging |
Het |
| Vcp |
G |
A |
4: 42,983,028 (GRCm39) |
T606I |
probably damaging |
Het |
| Zfhx4 |
C |
T |
3: 5,468,418 (GRCm39) |
P2859S |
probably benign |
Het |
| Zfp316 |
A |
G |
5: 143,240,874 (GRCm39) |
S382P |
possibly damaging |
Het |
|
| Other mutations in Or2t35 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0102:Or2t35
|
UTSW |
14 |
14,407,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0454:Or2t35
|
UTSW |
14 |
14,407,777 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1662:Or2t35
|
UTSW |
14 |
14,407,880 (GRCm38) |
nonsense |
probably null |
|
|
R2848:Or2t35
|
UTSW |
14 |
14,407,398 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4746:Or2t35
|
UTSW |
14 |
14,407,359 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4783:Or2t35
|
UTSW |
14 |
14,407,729 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4785:Or2t35
|
UTSW |
14 |
14,407,729 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R7121:Or2t35
|
UTSW |
14 |
14,407,998 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7159:Or2t35
|
UTSW |
14 |
14,407,251 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7704:Or2t35
|
UTSW |
14 |
14,407,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8683:Or2t35
|
UTSW |
14 |
14,407,480 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9664:Or2t35
|
UTSW |
14 |
14,407,963 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9767:Or2t35
|
UTSW |
14 |
14,407,929 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9769:Or2t35
|
UTSW |
14 |
14,407,929 (GRCm38) |
missense |
probably damaging |
0.98 |
|
X0065:Or2t35
|
UTSW |
14 |
14,408,007 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Or2t35
|
UTSW |
14 |
14,407,732 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACGTGTTCCTCCCACATTATAG -3'
(R):5'- AGCCCTCATATCTCATTCTTAAGTGG -3'
Sequencing Primer
(F):5'- GTTCCTCCCACATTATAGTAGTGAG -3'
(R):5'- CAGAAAGATTGTGACATCCAC -3'
|
| Posted On |
2015-04-29 |
Incidental Mutation