Incidental Mutation 'R4005:Ogn'
ID 311445
Institutional Source Beutler Lab
Gene Symbol Ogn
Ensembl Gene ENSMUSG00000021390
Gene Name osteoglycin
Synonyms 3110079A16Rik, SLRR3A, mimican, mimecan, OG
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.403) question?
Stock # R4005 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 49761522-49777977 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 49762775 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Alanine at position 39 (E39A)
Ref Sequence ENSEMBL: ENSMUSP00000021822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021818] [ENSMUST00000021822]
AlphaFold Q62000
Predicted Effect probably benign
Transcript: ENSMUST00000021818
SMART Domains Protein: ENSMUSP00000021818
Gene: ENSMUSG00000021391

DomainStartEndE-ValueType
coiled coil region 1 34 N/A INTRINSIC
Pfam:CENP-P 102 278 3.9e-89 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000021822
AA Change: E39A

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000021822
Gene: ENSMUSG00000021390
AA Change: E39A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 93 123 3.52e0 SMART
LRR_TYP 142 165 4.4e-2 SMART
LRR 166 187 1.33e2 SMART
LRR 212 235 3.78e-1 SMART
LRR 236 256 5.27e1 SMART
low complexity region 263 271 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221751
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adar T A 3: 89,657,094 (GRCm39) L488Q probably damaging Het
Ajm1 T C 2: 25,468,868 (GRCm39) T348A probably benign Het
Arhgef26 T C 3: 62,247,816 (GRCm39) M300T probably benign Het
Asl C T 5: 130,047,673 (GRCm39) probably null Het
Capn10 T A 1: 92,868,313 (GRCm39) L260Q probably damaging Het
Cdhr3 T C 12: 33,130,355 (GRCm39) D160G probably damaging Het
Cep290 A G 10: 100,374,870 (GRCm39) E1372G probably damaging Het
Cpeb2 A G 5: 43,395,755 (GRCm39) probably benign Het
Cpeb4 G A 11: 31,875,390 (GRCm39) A530T probably damaging Het
Cstl1 A T 2: 148,597,190 (GRCm39) I64F probably damaging Het
Ddx28 C G 8: 106,737,560 (GRCm39) R166P possibly damaging Het
Dgkd T C 1: 87,863,145 (GRCm39) I64T possibly damaging Het
Dmxl2 T C 9: 54,353,674 (GRCm39) I765V probably benign Het
Edem3 T C 1: 151,635,506 (GRCm39) M60T probably damaging Het
Farp1 C T 14: 121,513,809 (GRCm39) R844W probably damaging Het
Fat3 G A 9: 15,909,567 (GRCm39) S2145F probably damaging Het
Hmcn1 C G 1: 150,598,204 (GRCm39) L1699F possibly damaging Het
Igsf10 A T 3: 59,235,981 (GRCm39) L1400H probably benign Het
Ikzf3 C T 11: 98,379,843 (GRCm39) E142K probably damaging Het
Ilkap T A 1: 91,312,985 (GRCm39) N170I probably benign Het
Kctd3 T G 1: 188,734,124 (GRCm39) I39L possibly damaging Het
Lrit3 C A 3: 129,585,021 (GRCm39) V246L probably benign Het
Magi1 A G 6: 93,678,299 (GRCm39) I619T probably damaging Het
Map1b G T 13: 99,566,415 (GRCm39) P2102H unknown Het
Mcm10 G T 2: 5,005,814 (GRCm39) S440R probably damaging Het
Mtss2 CG CGG 8: 111,465,673 (GRCm39) probably null Het
Nlrp9a A G 7: 26,257,975 (GRCm39) N531S probably benign Het
Nrcam T A 12: 44,579,429 (GRCm39) D31E probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or4g17 G A 2: 111,210,088 (GRCm39) V248I probably benign Het
Or52z14 A G 7: 103,253,470 (GRCm39) Y203C probably damaging Het
Or5b94 A T 19: 12,652,210 (GRCm39) I214L probably benign Het
Pramel20 A G 4: 143,298,839 (GRCm39) T261A probably benign Het
Rgs2 T A 1: 143,877,606 (GRCm39) I150L probably benign Het
Rnf19a A T 15: 36,245,774 (GRCm39) D490E probably damaging Het
Spag5 T C 11: 78,212,355 (GRCm39) M1101T probably benign Het
Ulk4 A T 9: 120,997,265 (GRCm39) L769Q possibly damaging Het
Ythdc2 A G 18: 44,966,195 (GRCm39) S144G probably benign Het
Other mutations in Ogn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Ogn APN 13 49,774,514 (GRCm39) missense probably damaging 1.00
IGL00475:Ogn APN 13 49,776,391 (GRCm39) missense probably benign 0.01
IGL01830:Ogn APN 13 49,762,723 (GRCm39) nonsense probably null
R0116:Ogn UTSW 13 49,774,514 (GRCm39) missense possibly damaging 0.89
R1546:Ogn UTSW 13 49,762,809 (GRCm39) missense probably benign 0.00
R1554:Ogn UTSW 13 49,774,520 (GRCm39) missense probably benign 0.00
R3752:Ogn UTSW 13 49,776,307 (GRCm39) missense probably benign 0.44
R5323:Ogn UTSW 13 49,762,817 (GRCm39) missense probably benign 0.00
R5946:Ogn UTSW 13 49,771,761 (GRCm39) missense probably benign 0.01
R7854:Ogn UTSW 13 49,774,514 (GRCm39) missense possibly damaging 0.89
R7970:Ogn UTSW 13 49,762,742 (GRCm39) missense probably benign
R8426:Ogn UTSW 13 49,774,567 (GRCm39) missense possibly damaging 0.80
R9558:Ogn UTSW 13 49,764,783 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TCCACAGTCATCAGGTCAGTCAC -3'
(R):5'- ACGCAACTCTAGGATCTTATGTAGC -3'

Sequencing Primer
(F):5'- AGGTCAGTCACTCCTAACTTCAG -3'
(R):5'- CAGCTATCACCTTAAAGTCTAATGTC -3'
Posted On 2015-04-29