Incidental Mutation 'R0384:Vmn2r27'
ID 31166
Institutional Source Beutler Lab
Gene Symbol Vmn2r27
Ensembl Gene ENSMUSG00000072778
Gene Name vomeronasal 2, receptor27
Synonyms EG232367
MMRRC Submission 038590-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R0384 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 124168555-124208743 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 124200871 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 362 (V362A)
Ref Sequence ENSEMBL: ENSMUSP00000098528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100968]
AlphaFold D3YUK6
Predicted Effect probably benign
Transcript: ENSMUST00000100968
AA Change: V362A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000098528
Gene: ENSMUSG00000072778
AA Change: V362A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 81 475 1.1e-27 PFAM
Pfam:NCD3G 519 570 1.3e-18 PFAM
Pfam:7tm_3 603 838 2.6e-50 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.8%
  • 20x: 91.7%
Validation Efficiency 100% (72/72)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam8 T A 7: 139,566,725 (GRCm39) probably benign Het
Akr1b8 T C 6: 34,341,265 (GRCm39) probably benign Het
Arhgef39 A G 4: 43,498,613 (GRCm39) L117P probably damaging Het
Atp13a1 A T 8: 70,249,974 (GRCm39) Q356L possibly damaging Het
Bmp2k T A 5: 97,178,984 (GRCm39) probably benign Het
Ccdc141 A G 2: 76,857,992 (GRCm39) V1063A probably damaging Het
Col20a1 T C 2: 180,640,955 (GRCm39) Y568H probably benign Het
Crabp2 T C 3: 87,860,328 (GRCm39) V134A possibly damaging Het
Cyp19a1 T C 9: 54,080,025 (GRCm39) K265E probably benign Het
Cyp2j9 T C 4: 96,474,122 (GRCm39) H106R probably benign Het
Dcps T C 9: 35,087,239 (GRCm39) K9R probably damaging Het
Dnajc6 C T 4: 101,456,153 (GRCm39) T47I probably damaging Het
Dnhd1 T G 7: 105,369,321 (GRCm39) S4315A possibly damaging Het
Dnmt3l A T 10: 77,888,571 (GRCm39) I158F possibly damaging Het
Dock3 A G 9: 106,779,094 (GRCm39) probably benign Het
Eefsec A G 6: 88,258,632 (GRCm39) probably null Het
Fam204a T C 19: 60,209,728 (GRCm39) M1V probably null Het
Fam98b T C 2: 117,098,328 (GRCm39) V266A possibly damaging Het
Fat2 A T 11: 55,160,291 (GRCm39) I3274N possibly damaging Het
Fbh1 A G 2: 11,754,389 (GRCm39) I198T probably damaging Het
Fer T C 17: 64,231,179 (GRCm39) probably benign Het
Fhad1 T A 4: 141,729,737 (GRCm39) M89L probably benign Het
Fjx1 C A 2: 102,281,452 (GRCm39) C161F probably damaging Het
Fkbp7 T A 2: 76,496,168 (GRCm39) probably benign Het
Gm42669 T A 5: 107,656,664 (GRCm39) C976S probably benign Het
Gm4845 T C 1: 141,184,823 (GRCm39) noncoding transcript Het
Herc1 T A 9: 66,388,332 (GRCm39) probably benign Het
Hook3 C T 8: 26,534,263 (GRCm39) probably null Het
Idh2 C T 7: 79,748,005 (GRCm39) A232T probably damaging Het
Itga2b A T 11: 102,356,188 (GRCm39) probably null Het
Klk1b21 T C 7: 43,754,917 (GRCm39) Y71H probably benign Het
Kndc1 A T 7: 139,490,515 (GRCm39) N339I possibly damaging Het
Ky C T 9: 102,419,289 (GRCm39) T432I probably benign Het
Map4 C T 9: 109,863,696 (GRCm39) T307I probably damaging Het
Matn1 T C 4: 130,671,787 (GRCm39) L18P probably benign Het
Mindy4 G A 6: 55,193,669 (GRCm39) D121N probably damaging Het
Mpv17l A T 16: 13,758,863 (GRCm39) I96L probably benign Het
Msto1 G A 3: 88,817,646 (GRCm39) Q441* probably null Het
Muc5ac A G 7: 141,365,988 (GRCm39) H2048R possibly damaging Het
Musk T C 4: 58,373,711 (GRCm39) *879Q probably null Het
Nat8f2 T C 6: 85,845,350 (GRCm39) Y4C possibly damaging Het
Ncaph2 T A 15: 89,253,594 (GRCm39) I282N probably benign Het
Nid1 A G 13: 13,638,421 (GRCm39) T114A probably benign Het
Npr1 C A 3: 90,372,474 (GRCm39) G113C probably damaging Het
Nrxn1 G A 17: 90,515,775 (GRCm39) P193S probably damaging Het
Nwd2 T C 5: 63,963,025 (GRCm39) F870L probably benign Het
Or10h1b A G 17: 33,395,522 (GRCm39) I45V probably damaging Het
Or4c122 A G 2: 89,079,414 (GRCm39) I208T possibly damaging Het
Or6c5c T A 10: 129,298,909 (GRCm39) Y121* probably null Het
Or8k30 T A 2: 86,339,727 (GRCm39) I308K possibly damaging Het
Phf14 A G 6: 11,997,019 (GRCm39) probably benign Het
Pnpla5 G T 15: 84,004,920 (GRCm39) L144M probably damaging Het
Prdm2 T C 4: 142,862,258 (GRCm39) E344G probably benign Het
Psmd12 T C 11: 107,376,547 (GRCm39) V61A probably benign Het
Relt T C 7: 100,496,712 (GRCm39) D385G probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Scg2 T A 1: 79,413,266 (GRCm39) I446F probably benign Het
Sema3b G A 9: 107,478,165 (GRCm39) L407F probably damaging Het
Slc25a13 A T 6: 6,042,600 (GRCm39) Y601* probably null Het
Sun5 C T 2: 153,700,885 (GRCm39) V270I probably benign Het
Tex52 A G 6: 128,356,496 (GRCm39) Y63C probably damaging Het
Tmem138 A G 19: 10,552,186 (GRCm39) probably benign Het
Tnpo3 A G 6: 29,582,163 (GRCm39) probably null Het
Tspoap1 A T 11: 87,657,280 (GRCm39) Q364L probably damaging Het
Ttc41 T C 10: 86,599,811 (GRCm39) L1037P probably damaging Het
Ugcg T A 4: 59,220,387 (GRCm39) D393E possibly damaging Het
Vmn1r184 T C 7: 25,967,076 (GRCm39) I274T probably benign Het
Vmn2r87 T A 10: 130,307,712 (GRCm39) Y842F probably benign Het
Vps8 T A 16: 21,325,575 (GRCm39) probably benign Het
Other mutations in Vmn2r27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Vmn2r27 APN 6 124,169,370 (GRCm39) missense possibly damaging 0.86
IGL01388:Vmn2r27 APN 6 124,200,791 (GRCm39) missense possibly damaging 0.55
IGL01923:Vmn2r27 APN 6 124,177,484 (GRCm39) missense probably benign 0.20
IGL01954:Vmn2r27 APN 6 124,169,207 (GRCm39) missense probably damaging 1.00
IGL02105:Vmn2r27 APN 6 124,174,308 (GRCm39) splice site probably benign
IGL02586:Vmn2r27 APN 6 124,201,434 (GRCm39) nonsense probably null
IGL03130:Vmn2r27 APN 6 124,169,276 (GRCm39) missense possibly damaging 0.82
IGL03330:Vmn2r27 APN 6 124,207,139 (GRCm39) nonsense probably null
R0124:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0234:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0234:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0582:Vmn2r27 UTSW 6 124,201,249 (GRCm39) missense probably benign 0.02
R0733:Vmn2r27 UTSW 6 124,169,147 (GRCm39) missense probably benign 0.18
R0738:Vmn2r27 UTSW 6 124,200,661 (GRCm39) missense possibly damaging 0.48
R0835:Vmn2r27 UTSW 6 124,177,583 (GRCm39) missense probably damaging 0.99
R1183:Vmn2r27 UTSW 6 124,177,491 (GRCm39) missense probably benign
R1401:Vmn2r27 UTSW 6 124,168,591 (GRCm39) nonsense probably null
R1484:Vmn2r27 UTSW 6 124,177,474 (GRCm39) missense probably damaging 0.96
R1536:Vmn2r27 UTSW 6 124,177,649 (GRCm39) missense probably damaging 1.00
R1539:Vmn2r27 UTSW 6 124,168,730 (GRCm39) missense probably damaging 1.00
R1565:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1595:Vmn2r27 UTSW 6 124,208,574 (GRCm39) missense probably benign 0.00
R1614:Vmn2r27 UTSW 6 124,200,893 (GRCm39) missense probably benign 0.01
R1742:Vmn2r27 UTSW 6 124,177,636 (GRCm39) missense possibly damaging 0.48
R1816:Vmn2r27 UTSW 6 124,207,330 (GRCm39) nonsense probably null
R1822:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1824:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1870:Vmn2r27 UTSW 6 124,201,170 (GRCm39) missense probably benign 0.11
R1942:Vmn2r27 UTSW 6 124,200,722 (GRCm39) missense probably damaging 1.00
R1962:Vmn2r27 UTSW 6 124,200,793 (GRCm39) missense possibly damaging 0.70
R2069:Vmn2r27 UTSW 6 124,201,442 (GRCm39) missense probably damaging 1.00
R2075:Vmn2r27 UTSW 6 124,177,510 (GRCm39) missense possibly damaging 0.85
R2379:Vmn2r27 UTSW 6 124,201,342 (GRCm39) missense possibly damaging 0.89
R3748:Vmn2r27 UTSW 6 124,207,351 (GRCm39) missense probably benign 0.35
R4384:Vmn2r27 UTSW 6 124,201,115 (GRCm39) missense probably benign 0.05
R4392:Vmn2r27 UTSW 6 124,207,135 (GRCm39) missense probably benign 0.01
R4758:Vmn2r27 UTSW 6 124,208,596 (GRCm39) missense possibly damaging 0.87
R5018:Vmn2r27 UTSW 6 124,201,141 (GRCm39) missense probably benign 0.02
R5235:Vmn2r27 UTSW 6 124,169,013 (GRCm39) missense probably damaging 0.99
R5718:Vmn2r27 UTSW 6 124,169,103 (GRCm39) missense possibly damaging 0.66
R5859:Vmn2r27 UTSW 6 124,177,647 (GRCm39) missense probably damaging 1.00
R5958:Vmn2r27 UTSW 6 124,208,686 (GRCm39) missense probably benign 0.00
R6044:Vmn2r27 UTSW 6 124,208,731 (GRCm39) missense probably benign
R6086:Vmn2r27 UTSW 6 124,168,958 (GRCm39) missense probably damaging 1.00
R6396:Vmn2r27 UTSW 6 124,201,125 (GRCm39) nonsense probably null
R6546:Vmn2r27 UTSW 6 124,169,369 (GRCm39) missense possibly damaging 0.49
R6746:Vmn2r27 UTSW 6 124,177,552 (GRCm39) missense possibly damaging 0.47
R6976:Vmn2r27 UTSW 6 124,201,312 (GRCm39) nonsense probably null
R7091:Vmn2r27 UTSW 6 124,200,904 (GRCm39) missense possibly damaging 0.85
R7145:Vmn2r27 UTSW 6 124,168,711 (GRCm39) missense probably benign
R7176:Vmn2r27 UTSW 6 124,168,995 (GRCm39) missense probably benign 0.01
R7382:Vmn2r27 UTSW 6 124,174,276 (GRCm39) missense probably damaging 1.00
R7482:Vmn2r27 UTSW 6 124,201,220 (GRCm39) missense probably damaging 1.00
R7853:Vmn2r27 UTSW 6 124,168,980 (GRCm39) missense probably damaging 1.00
R7859:Vmn2r27 UTSW 6 124,201,201 (GRCm39) missense probably benign 0.00
R7959:Vmn2r27 UTSW 6 124,169,040 (GRCm39) missense probably benign
R8266:Vmn2r27 UTSW 6 124,168,937 (GRCm39) missense probably benign 0.00
R8353:Vmn2r27 UTSW 6 124,169,404 (GRCm39) missense probably damaging 0.99
R8394:Vmn2r27 UTSW 6 124,168,776 (GRCm39) missense possibly damaging 0.71
R8463:Vmn2r27 UTSW 6 124,169,168 (GRCm39) missense probably damaging 1.00
R8477:Vmn2r27 UTSW 6 124,201,200 (GRCm39) missense probably benign 0.11
R8705:Vmn2r27 UTSW 6 124,207,188 (GRCm39) missense probably damaging 1.00
R8752:Vmn2r27 UTSW 6 124,201,018 (GRCm39) missense probably benign 0.00
R9109:Vmn2r27 UTSW 6 124,174,224 (GRCm39) missense possibly damaging 0.95
R9140:Vmn2r27 UTSW 6 124,169,207 (GRCm39) missense probably damaging 1.00
R9157:Vmn2r27 UTSW 6 124,201,244 (GRCm39) missense probably benign 0.09
R9431:Vmn2r27 UTSW 6 124,168,856 (GRCm39) missense probably damaging 1.00
R9477:Vmn2r27 UTSW 6 124,168,910 (GRCm39) missense probably damaging 0.99
R9758:Vmn2r27 UTSW 6 124,168,637 (GRCm39) missense possibly damaging 0.89
Z1177:Vmn2r27 UTSW 6 124,168,860 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCATACACAGCAGCATGGAC -3'
(R):5'- AGACATGACCAAGCACGGACTTTG -3'

Sequencing Primer
(F):5'- CAGCAGCATGGACTTTGTAGC -3'
(R):5'- GACCAAGCACGGACTTTGTATTG -3'
Posted On 2013-04-24