Incidental Mutation 'R4014:Krt26'
ID 311874
Institutional Source Beutler Lab
Gene Symbol Krt26
Ensembl Gene ENSMUSG00000075570
Gene Name keratin 26
Synonyms 4732407F15Rik
MMRRC Submission 040951-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R4014 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 99219376-99228792 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 99226128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 189 (G189S)
Ref Sequence ENSEMBL: ENSMUSP00000098051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100482]
AlphaFold Q3TRJ4
Predicted Effect probably damaging
Transcript: ENSMUST00000100482
AA Change: G189S

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000098051
Gene: ENSMUSG00000075570
AA Change: G189S

DomainStartEndE-ValueType
low complexity region 40 65 N/A INTRINSIC
Filament 79 394 1.1e-132 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148770
Meta Mutation Damage Score 0.5187 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 A T 19: 43,811,559 (GRCm39) Q1008L probably benign Het
Adgrg7 A G 16: 56,562,651 (GRCm39) F562S probably damaging Het
Alms1 T A 6: 85,655,334 (GRCm39) N3293K probably benign Het
Cdk20 T A 13: 64,585,319 (GRCm39) V201D probably benign Het
Cenpf A G 1: 189,385,356 (GRCm39) V2308A probably benign Het
Chek1 T C 9: 36,634,050 (GRCm39) probably benign Het
Ciz1 G T 2: 32,264,356 (GRCm39) E497D probably damaging Het
Clcn6 A G 4: 148,102,067 (GRCm39) F339S probably damaging Het
Dctpp1 G A 7: 126,856,285 (GRCm39) R146C probably damaging Het
Dennd5a C T 7: 109,534,688 (GRCm39) probably null Het
Dmxl1 G A 18: 49,997,029 (GRCm39) V442I probably benign Het
Dmxl2 C A 9: 54,285,993 (GRCm39) probably null Het
Dnah11 A G 12: 117,938,649 (GRCm39) I3273T probably benign Het
Dnhd1 T A 7: 105,364,045 (GRCm39) D4132E probably damaging Het
Dst G A 1: 34,230,363 (GRCm39) W2327* probably null Het
Epb41 A T 4: 131,709,756 (GRCm39) probably benign Het
Frem2 C T 3: 53,559,774 (GRCm39) V1578I probably benign Het
Fsip2 A G 2: 82,813,862 (GRCm39) T3394A probably benign Het
Gabra5 C T 7: 57,138,758 (GRCm39) D97N probably damaging Het
Habp2 A G 19: 56,308,054 (GRCm39) E546G probably benign Het
Hace1 A G 10: 45,464,470 (GRCm39) probably benign Het
Herc4 T C 10: 63,123,323 (GRCm39) S433P probably benign Het
Igf2bp2 T C 16: 21,882,426 (GRCm39) N425S probably damaging Het
Lama2 A T 10: 26,860,372 (GRCm39) D3038E probably damaging Het
Lmbrd2 T C 15: 9,151,672 (GRCm39) probably benign Het
Lrp1b A G 2: 40,692,996 (GRCm39) F3401L possibly damaging Het
Map2k7 T A 8: 4,297,663 (GRCm39) S421R possibly damaging Het
Matn1 A G 4: 130,679,258 (GRCm39) Q304R possibly damaging Het
Muc4 C T 16: 32,575,647 (GRCm39) probably benign Het
Muc5b G A 7: 141,417,367 (GRCm39) V3438M probably benign Het
Myo3a A G 2: 22,468,182 (GRCm39) R479G possibly damaging Het
Mzf1 A G 7: 12,777,883 (GRCm39) V586A possibly damaging Het
Or7g12 T C 9: 18,900,178 (GRCm39) V298A probably benign Het
Or9g20 A T 2: 85,629,820 (GRCm39) Y265N probably damaging Het
Pcdhgb7 A T 18: 37,885,416 (GRCm39) E195D probably benign Het
Pde4b A G 4: 102,412,822 (GRCm39) D199G probably benign Het
Rnf213 C T 11: 119,336,555 (GRCm39) Q3309* probably null Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Slc22a4 C G 11: 53,888,218 (GRCm39) C270S probably benign Het
Smarca2 G A 19: 26,661,327 (GRCm39) probably null Het
Spata31d1c T C 13: 65,183,213 (GRCm39) S252P probably damaging Het
Tyr A G 7: 87,087,148 (GRCm39) S455P probably benign Het
Urb1 A T 16: 90,566,353 (GRCm39) M1478K probably damaging Het
Usp1 A G 4: 98,822,939 (GRCm39) D751G probably damaging Het
Vmn1r214 G A 13: 23,219,520 (GRCm39) C338Y probably benign Het
Vmn2r103 A G 17: 20,013,866 (GRCm39) I219M possibly damaging Het
Wwp2 A G 8: 108,212,253 (GRCm39) N139S probably benign Het
Other mutations in Krt26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00970:Krt26 APN 11 99,222,107 (GRCm39) missense probably benign 0.00
IGL02019:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02138:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02188:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02189:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02192:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02647:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
IGL02651:Krt26 APN 11 99,224,471 (GRCm39) missense probably benign 0.30
R0122:Krt26 UTSW 11 99,224,545 (GRCm39) nonsense probably null
R1842:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R1843:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R1923:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R1924:Krt26 UTSW 11 99,224,352 (GRCm39) small deletion probably benign
R3872:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R3873:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R3874:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R3875:Krt26 UTSW 11 99,225,570 (GRCm39) missense probably damaging 1.00
R4939:Krt26 UTSW 11 99,225,522 (GRCm39) missense probably benign 0.03
R5620:Krt26 UTSW 11 99,228,597 (GRCm39) missense possibly damaging 0.86
R6035:Krt26 UTSW 11 99,224,415 (GRCm39) missense probably benign 0.43
R6035:Krt26 UTSW 11 99,224,415 (GRCm39) missense probably benign 0.43
R6151:Krt26 UTSW 11 99,228,315 (GRCm39) missense probably benign 0.35
R6578:Krt26 UTSW 11 99,225,628 (GRCm39) missense probably damaging 1.00
R6626:Krt26 UTSW 11 99,220,528 (GRCm39) missense probably benign 0.28
R7413:Krt26 UTSW 11 99,225,887 (GRCm39) missense probably benign 0.25
R7557:Krt26 UTSW 11 99,225,567 (GRCm39) missense probably damaging 1.00
R7919:Krt26 UTSW 11 99,224,420 (GRCm39) missense probably damaging 1.00
R8051:Krt26 UTSW 11 99,228,672 (GRCm39) missense probably damaging 0.97
R8090:Krt26 UTSW 11 99,227,315 (GRCm39) missense probably benign 0.13
R8163:Krt26 UTSW 11 99,220,498 (GRCm39) missense probably benign 0.00
R8211:Krt26 UTSW 11 99,226,110 (GRCm39) missense probably damaging 0.98
R8480:Krt26 UTSW 11 99,228,426 (GRCm39) missense probably damaging 1.00
R9040:Krt26 UTSW 11 99,222,093 (GRCm39) missense probably benign 0.00
R9418:Krt26 UTSW 11 99,228,741 (GRCm39) start gained probably benign
Z1186:Krt26 UTSW 11 99,228,643 (GRCm39) missense probably damaging 0.99
Z1191:Krt26 UTSW 11 99,228,643 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GAGGATTTCAGTTGACATCCACATC -3'
(R):5'- TCCCAAACCATCTTAATAGTTTGCC -3'

Sequencing Primer
(F):5'- CACATCCTGCTATGGAATGAACAGTG -3'
(R):5'- TGCCATTGCAAGAAACCTTGG -3'
Posted On 2015-04-29