Incidental Mutation 'R4016:Slc16a14'
ID 311927
Institutional Source Beutler Lab
Gene Symbol Slc16a14
Ensembl Gene ENSMUSG00000026220
Gene Name solute carrier family 16 (monocarboxylic acid transporters), member 14
Synonyms 1110004H10Rik
MMRRC Submission 040847-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R4016 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 84883619-84912855 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 84890228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 359 (S359*)
Ref Sequence ENSEMBL: ENSMUSP00000027422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027422]
AlphaFold Q8K1C7
Predicted Effect probably null
Transcript: ENSMUST00000027422
AA Change: S359*
SMART Domains Protein: ENSMUSP00000027422
Gene: ENSMUSG00000026220
AA Change: S359*

DomainStartEndE-ValueType
Pfam:MFS_1 42 427 6.7e-42 PFAM
Pfam:MFS_1 419 509 7.9e-10 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency 100% (49/49)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh8a1 G A 10: 21,271,470 (GRCm39) V399I probably benign Het
Apold1 A G 6: 134,960,869 (GRCm39) I108V probably benign Het
Arpc5 G A 1: 152,644,607 (GRCm39) probably benign Het
Capn11 T A 17: 45,964,682 (GRCm39) D45V probably damaging Het
Dctpp1 G A 7: 126,856,285 (GRCm39) R146C probably damaging Het
Dlat C T 9: 50,560,931 (GRCm39) probably null Het
Dock10 T A 1: 80,584,286 (GRCm39) D140V probably damaging Het
Dtx3 A G 10: 127,027,040 (GRCm39) V378A probably benign Het
Ezh2 A G 6: 47,521,516 (GRCm39) I414T probably benign Het
Gm1979 C T 5: 26,209,604 (GRCm39) W41* probably null Het
Igf2bp2 T C 16: 21,882,426 (GRCm39) N425S probably damaging Het
Kdm5a T A 6: 120,371,067 (GRCm39) Y504N probably damaging Het
Map3k21 T A 8: 126,637,924 (GRCm39) I170N probably damaging Het
Mrgpra6 C A 7: 46,838,463 (GRCm39) C245F possibly damaging Het
Nipal2 T G 15: 34,600,207 (GRCm39) K203N possibly damaging Het
Nlrp1b A G 11: 71,063,911 (GRCm39) F621S probably damaging Het
Nos3 G A 5: 24,576,714 (GRCm39) V448M probably damaging Het
Ntrk3 G T 7: 78,112,695 (GRCm39) probably benign Het
Or5b118 A T 19: 13,448,561 (GRCm39) T76S possibly damaging Het
P2rx1 T C 11: 72,900,799 (GRCm39) C190R probably damaging Het
Pdzrn4 T A 15: 92,297,630 (GRCm39) D198E probably benign Het
Ptar1 A G 19: 23,664,824 (GRCm39) M1V probably null Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Purg T A 8: 33,877,019 (GRCm39) L219* probably null Het
Rbp3 G T 14: 33,677,347 (GRCm39) V432L possibly damaging Het
Scnn1b G T 7: 121,513,555 (GRCm39) probably null Het
Sgms1 A G 19: 32,120,192 (GRCm39) V238A possibly damaging Het
Smarca2 G A 19: 26,661,327 (GRCm39) probably null Het
Spatc1l A G 10: 76,398,323 (GRCm39) S42G probably benign Het
Stra6 T A 9: 58,042,473 (GRCm39) V34E probably damaging Het
Tex14 A G 11: 87,429,449 (GRCm39) probably null Het
Tox4 T C 14: 52,523,361 (GRCm39) probably null Het
Tyr A G 7: 87,087,148 (GRCm39) S455P probably benign Het
Uggt2 T C 14: 119,263,845 (GRCm39) N1062D possibly damaging Het
Umod A C 7: 119,075,913 (GRCm39) N284K possibly damaging Het
Unc93b1 T C 19: 3,993,572 (GRCm39) I338T probably damaging Het
Vmn2r99 C T 17: 19,598,832 (GRCm39) T172I possibly damaging Het
Whrn G A 4: 63,333,876 (GRCm39) Q415* probably null Het
Other mutations in Slc16a14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Slc16a14 APN 1 84,900,592 (GRCm39) missense probably damaging 0.99
IGL01563:Slc16a14 APN 1 84,889,908 (GRCm39) splice site probably benign
R0315:Slc16a14 UTSW 1 84,890,217 (GRCm39) missense possibly damaging 0.46
R0380:Slc16a14 UTSW 1 84,907,251 (GRCm39) missense possibly damaging 0.72
R1469:Slc16a14 UTSW 1 84,907,182 (GRCm39) missense probably damaging 1.00
R1469:Slc16a14 UTSW 1 84,907,182 (GRCm39) missense probably damaging 1.00
R1837:Slc16a14 UTSW 1 84,890,120 (GRCm39) missense probably benign 0.02
R2149:Slc16a14 UTSW 1 84,885,120 (GRCm39) missense probably damaging 1.00
R2293:Slc16a14 UTSW 1 84,890,564 (GRCm39) missense probably benign
R3790:Slc16a14 UTSW 1 84,907,001 (GRCm39) unclassified probably benign
R4596:Slc16a14 UTSW 1 84,907,078 (GRCm39) missense probably damaging 1.00
R4637:Slc16a14 UTSW 1 84,885,003 (GRCm39) missense possibly damaging 0.86
R4723:Slc16a14 UTSW 1 84,890,741 (GRCm39) missense probably damaging 1.00
R5137:Slc16a14 UTSW 1 84,890,318 (GRCm39) missense probably damaging 1.00
R5262:Slc16a14 UTSW 1 84,890,612 (GRCm39) missense probably benign 0.00
R5410:Slc16a14 UTSW 1 84,885,145 (GRCm39) missense probably damaging 0.98
R5927:Slc16a14 UTSW 1 84,889,988 (GRCm39) missense possibly damaging 0.91
R5968:Slc16a14 UTSW 1 84,890,226 (GRCm39) missense possibly damaging 0.70
R6052:Slc16a14 UTSW 1 84,890,430 (GRCm39) missense possibly damaging 0.75
R6264:Slc16a14 UTSW 1 84,885,130 (GRCm39) missense probably benign 0.30
R6290:Slc16a14 UTSW 1 84,885,106 (GRCm39) missense probably benign 0.10
R7383:Slc16a14 UTSW 1 84,890,292 (GRCm39) missense probably damaging 1.00
R7390:Slc16a14 UTSW 1 84,907,187 (GRCm39) missense probably benign 0.25
R7535:Slc16a14 UTSW 1 84,890,843 (GRCm39) missense probably damaging 1.00
R8326:Slc16a14 UTSW 1 84,890,066 (GRCm39) missense possibly damaging 0.94
R8669:Slc16a14 UTSW 1 84,900,605 (GRCm39) missense probably benign 0.00
R8784:Slc16a14 UTSW 1 84,890,784 (GRCm39) missense probably benign 0.01
R9409:Slc16a14 UTSW 1 84,907,116 (GRCm39) nonsense probably null
R9469:Slc16a14 UTSW 1 84,900,612 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TAGGGCACAAATGACAGCC -3'
(R):5'- GGTTCTGAAGACAGTGAGCC -3'

Sequencing Primer
(F):5'- ATGACAGCCAGACTCGCGTAG -3'
(R):5'- TTCTGAAGACAGTGAGCCAGCTC -3'
Posted On 2015-04-29