Incidental Mutation 'R3962:Or6c207'
ID 312134
Institutional Source Beutler Lab
Gene Symbol Or6c207
Ensembl Gene ENSMUSG00000062914
Gene Name olfactory receptor family 6 subfamily C member 207
Synonyms Olfr777, MOR114-9, GA_x6K02T2PULF-10955551-10954616
MMRRC Submission 040837-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R3962 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129104255-129105190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129104535 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 219 (I219N)
Ref Sequence ENSEMBL: ENSMUSP00000145475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080313] [ENSMUST00000204573] [ENSMUST00000213512]
AlphaFold Q8VFH3
Predicted Effect probably damaging
Transcript: ENSMUST00000080313
AA Change: I219N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000079191
Gene: ENSMUSG00000062914
AA Change: I219N

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204573
AA Change: I219N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914
AA Change: I219N

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213512
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,838,803 (GRCm39) T595A possibly damaging Het
Abca12 A T 1: 71,313,674 (GRCm39) probably null Het
Ablim2 C T 5: 35,969,519 (GRCm39) R211C probably damaging Het
Actn4 C A 7: 28,597,647 (GRCm39) probably null Het
B3gnt5 A G 16: 19,587,798 (GRCm39) S6G probably benign Het
Bod1l T G 5: 41,966,064 (GRCm39) E2667A probably benign Het
Ccdc13 G A 9: 121,628,005 (GRCm39) probably benign Het
Ccdc15 G T 9: 37,231,782 (GRCm39) R181S probably damaging Het
Ccnd1 G A 7: 144,487,787 (GRCm39) T230M probably damaging Het
Cdcp1 T C 9: 123,011,446 (GRCm39) T344A possibly damaging Het
Fam161a T C 11: 22,973,507 (GRCm39) M275T possibly damaging Het
Fbxo15 A G 18: 84,977,372 (GRCm39) T95A probably benign Het
Fndc5 T C 4: 129,033,688 (GRCm39) V152A probably benign Het
Galk2 A T 2: 125,735,293 (GRCm39) N107I probably benign Het
Glmn A T 5: 107,708,911 (GRCm39) probably benign Het
Gm5082 T C 13: 41,809,894 (GRCm39) noncoding transcript Het
Gm5828 C T 1: 16,838,868 (GRCm39) noncoding transcript Het
Haus6 C T 4: 86,530,041 (GRCm39) A4T possibly damaging Het
Hmgcs2 G A 3: 98,198,354 (GRCm39) V86M possibly damaging Het
Hrg G A 16: 22,774,825 (GRCm39) V152I possibly damaging Het
Itga2 A T 13: 114,976,054 (GRCm39) V1106E probably damaging Het
Itga9 G A 9: 118,457,254 (GRCm39) D122N possibly damaging Het
Kif21a T A 15: 90,869,612 (GRCm39) E413V probably damaging Het
Klk1 A G 7: 43,878,973 (GRCm39) T256A possibly damaging Het
L1td1 T C 4: 98,625,686 (GRCm39) V627A probably benign Het
Larp4 C A 15: 99,910,026 (GRCm39) Q652K probably damaging Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Minar1 G A 9: 89,483,963 (GRCm39) T478I probably damaging Het
Moxd2 T A 6: 40,862,331 (GRCm39) M163L probably benign Het
Myo15a G A 11: 60,370,654 (GRCm39) R1138H probably benign Het
Oasl2 A G 5: 115,035,808 (GRCm39) D28G probably benign Het
Platr26 A T 2: 71,549,849 (GRCm39) noncoding transcript Het
Ptdss1 A G 13: 67,142,075 (GRCm39) H411R probably benign Het
Ptpra A G 2: 30,325,672 (GRCm39) T147A probably damaging Het
Rfx2 T C 17: 57,092,302 (GRCm39) Y307C probably damaging Het
Rtn3 T C 19: 7,435,510 (GRCm39) S142G probably damaging Het
Shisa6 A G 11: 66,108,302 (GRCm39) V525A probably damaging Het
Slc4a3 A G 1: 75,533,398 (GRCm39) S1007G probably damaging Het
Spmip5 A G 19: 58,777,541 (GRCm39) Y82H probably damaging Het
Srsf3 C T 17: 29,255,430 (GRCm39) probably benign Het
Taar8a A G 10: 23,953,054 (GRCm39) I219M probably damaging Het
Tars2 A G 3: 95,662,068 (GRCm39) probably null Het
Tfap2d A G 1: 19,189,189 (GRCm39) N245S probably damaging Het
Tlr6 T A 5: 65,112,328 (GRCm39) H193L probably benign Het
Tomm20l T C 12: 71,164,352 (GRCm39) V78A probably benign Het
Tsc2 G A 17: 24,840,140 (GRCm39) probably benign Het
Usp2 A G 9: 43,986,954 (GRCm39) D84G possibly damaging Het
V1ra8 A G 6: 90,180,466 (GRCm39) N223S probably benign Het
Wnk2 C A 13: 49,224,453 (GRCm39) R1122L probably damaging Het
Other mutations in Or6c207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01302:Or6c207 APN 10 129,104,392 (GRCm39) missense probably benign 0.18
IGL01782:Or6c207 APN 10 129,104,908 (GRCm39) missense probably benign 0.00
R0554:Or6c207 UTSW 10 129,104,368 (GRCm39) missense probably benign 0.00
R0594:Or6c207 UTSW 10 129,105,021 (GRCm39) missense possibly damaging 0.95
R1792:Or6c207 UTSW 10 129,105,112 (GRCm39) missense probably benign 0.20
R2357:Or6c207 UTSW 10 129,104,642 (GRCm39) missense probably benign 0.31
R2426:Or6c207 UTSW 10 129,105,135 (GRCm39) missense probably benign 0.00
R3757:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R3758:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R4600:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4603:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4611:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R5113:Or6c207 UTSW 10 129,104,535 (GRCm39) missense probably damaging 0.98
R6415:Or6c207 UTSW 10 129,104,890 (GRCm39) missense probably benign 0.01
R7540:Or6c207 UTSW 10 129,105,003 (GRCm39) missense probably benign 0.31
R7909:Or6c207 UTSW 10 129,105,136 (GRCm39) missense probably benign 0.00
R8170:Or6c207 UTSW 10 129,104,917 (GRCm39) missense possibly damaging 0.80
R9079:Or6c207 UTSW 10 129,104,466 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TGAATGGGTTCAACATAGGAGC -3'
(R):5'- TGATCCTGCCACCACTTAGC -3'

Sequencing Primer
(F):5'- CAATGGAAGTGGTGAGAACCATC -3'
(R):5'- CTGGGCCTCAAGCTGAAATTCTG -3'
Posted On 2015-04-29