Incidental Mutation 'R3963:Grm7'
ID 312176
Institutional Source Beutler Lab
Gene Symbol Grm7
Ensembl Gene ENSMUSG00000056755
Gene Name glutamate receptor, metabotropic 7
Synonyms 6330570A01Rik, Gpr1g, mGlu7a receptor, mGluR7, E130018M02Rik
MMRRC Submission 040932-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3963 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 110622542-111544191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 110623309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 161 (V161F)
Ref Sequence ENSEMBL: ENSMUSP00000134635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071076] [ENSMUST00000172951] [ENSMUST00000174018]
AlphaFold Q68ED2
Predicted Effect probably damaging
Transcript: ENSMUST00000071076
AA Change: V161F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000064404
Gene: ENSMUSG00000056755
AA Change: V161F

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 3e-108 PFAM
Pfam:Peripla_BP_6 144 371 3e-11 PFAM
Pfam:NCD3G 519 569 1.2e-13 PFAM
Pfam:7tm_3 602 847 5.1e-59 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172951
AA Change: V161F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000133957
Gene: ENSMUSG00000056755
AA Change: V161F

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 1.7e-103 PFAM
Pfam:Peripla_BP_6 144 487 1e-12 PFAM
Pfam:NCD3G 519 569 1.2e-17 PFAM
Pfam:7tm_3 600 848 1.4e-87 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173609
Predicted Effect probably damaging
Transcript: ENSMUST00000174018
AA Change: V161F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134635
Gene: ENSMUSG00000056755
AA Change: V161F

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 176 4.9e-20 PFAM
Meta Mutation Damage Score 0.2357 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
PHENOTYPE: Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts18 T C 8: 114,504,443 (GRCm39) D59G probably benign Het
Ank2 A T 3: 126,728,245 (GRCm39) S783T probably benign Het
Arfgef3 T C 10: 18,468,025 (GRCm39) D1725G probably damaging Het
B3gnt5 A G 16: 19,587,798 (GRCm39) S6G probably benign Het
Btbd8 G A 5: 107,655,222 (GRCm39) C1007Y probably damaging Het
Ccdc82 C A 9: 13,252,011 (GRCm39) T101K possibly damaging Het
Ccdc85a A C 11: 28,526,396 (GRCm39) M376R probably benign Het
Cd200r1 T A 16: 44,613,158 (GRCm39) C255S probably benign Het
Cdc23 T C 18: 34,779,972 (GRCm39) M119V probably benign Het
Cers3 G T 7: 66,435,823 (GRCm39) A261S probably benign Het
Clptm1 C T 7: 19,372,121 (GRCm39) W238* probably null Het
Cr2 A G 1: 194,842,047 (GRCm39) V302A probably damaging Het
Cyp4a31 A G 4: 115,431,969 (GRCm39) probably benign Het
Dennd4a T A 9: 64,769,613 (GRCm39) I440N probably damaging Het
Dsc2 C T 18: 20,184,284 (GRCm39) V35I probably damaging Het
Dyrk1a T A 16: 94,464,605 (GRCm39) M71K probably benign Het
Exoc3l2 G A 7: 19,229,181 (GRCm39) G200S probably benign Het
Fhip2a T C 19: 57,361,442 (GRCm39) L122P possibly damaging Het
Fkbp15 A T 4: 62,258,914 (GRCm39) I114N probably damaging Het
Fpr-rs6 G A 17: 20,402,479 (GRCm39) P294L probably damaging Het
Frmd6 A G 12: 70,940,638 (GRCm39) T428A probably benign Het
G6pd2 T A 5: 61,966,228 (GRCm39) M1K probably null Het
Gdf3 C T 6: 122,583,717 (GRCm39) V217I probably benign Het
Gtf3c1 T C 7: 125,292,397 (GRCm39) probably null Het
Hrg G A 16: 22,774,825 (GRCm39) V152I possibly damaging Het
Itpkc T C 7: 26,926,934 (GRCm39) T327A probably damaging Het
Jade1 T C 3: 41,555,845 (GRCm39) V304A probably damaging Het
Leo1 C A 9: 75,357,762 (GRCm39) probably benign Het
Lrrc7 A T 3: 157,866,042 (GRCm39) L1233Q probably damaging Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Matn2 C A 15: 34,388,937 (GRCm39) Y342* probably null Het
Minar1 G A 9: 89,483,963 (GRCm39) T478I probably damaging Het
Mlh3 T C 12: 85,315,454 (GRCm39) H244R possibly damaging Het
Mmaa A T 8: 79,994,843 (GRCm39) V321E probably damaging Het
Ntng1 T A 3: 109,842,184 (GRCm39) L196F probably damaging Het
Oas1e A G 5: 120,932,205 (GRCm39) V146A probably damaging Het
Or52z1 G T 7: 103,437,241 (GRCm39) T81K probably benign Het
Plcxd2 T C 16: 45,800,864 (GRCm39) K120R probably damaging Het
Prex2 G T 1: 11,180,581 (GRCm39) C382F possibly damaging Het
Psg29 T A 7: 16,942,510 (GRCm39) H170Q probably benign Het
Ptprk A G 10: 28,427,661 (GRCm39) T747A probably damaging Het
Qki G A 17: 10,435,394 (GRCm39) probably benign Het
Rpusd2 A G 2: 118,869,085 (GRCm39) T503A probably benign Het
Rtn3 T C 19: 7,435,510 (GRCm39) S142G probably damaging Het
Slco1a5 C T 6: 142,194,370 (GRCm39) probably null Het
Snap91 A T 9: 86,657,665 (GRCm39) W509R probably damaging Het
Srsf3 C T 17: 29,255,430 (GRCm39) probably benign Het
Tmem267 A T 13: 119,629,175 (GRCm39) probably null Het
Tmem63a G A 1: 180,790,679 (GRCm39) D446N possibly damaging Het
Tnfaip8 C A 18: 50,223,653 (GRCm39) H154N possibly damaging Het
Trim35 T C 14: 66,541,503 (GRCm39) L209P probably damaging Het
Ttf1 A G 2: 28,954,816 (GRCm39) E60G possibly damaging Het
Ttf2 T C 3: 100,849,136 (GRCm39) probably benign Het
Tubg2 T C 11: 101,051,224 (GRCm39) probably null Het
Ubap1l C T 9: 65,276,477 (GRCm39) probably benign Het
Usp48 A T 4: 137,360,750 (GRCm39) R26* probably null Het
Vmn1r222 A G 13: 23,417,102 (GRCm39) V37A probably benign Het
Vmn2r4 T A 3: 64,322,572 (GRCm39) N49I probably damaging Het
Zfp979 A T 4: 147,697,588 (GRCm39) C374S probably benign Het
Other mutations in Grm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Grm7 APN 6 111,223,145 (GRCm39) missense probably benign 0.14
IGL02058:Grm7 APN 6 111,335,278 (GRCm39) missense probably damaging 1.00
IGL02650:Grm7 APN 6 111,335,919 (GRCm39) missense probably damaging 1.00
IGL02892:Grm7 APN 6 111,230,981 (GRCm39) missense probably damaging 0.99
IGL03074:Grm7 APN 6 111,472,604 (GRCm39) splice site probably null
IGL03185:Grm7 APN 6 110,623,183 (GRCm39) missense possibly damaging 0.84
Appropriated UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
Consumed UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
Devoured UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
Ravaged UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
shaky UTSW 6 111,472,752 (GRCm39) nonsense probably null
PIT4651001:Grm7 UTSW 6 110,623,050 (GRCm39) missense probably benign
R0539:Grm7 UTSW 6 111,336,055 (GRCm39) splice site probably benign
R0622:Grm7 UTSW 6 111,335,457 (GRCm39) missense probably damaging 1.00
R1356:Grm7 UTSW 6 111,335,985 (GRCm39) missense probably damaging 1.00
R1762:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1783:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1785:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1816:Grm7 UTSW 6 111,472,752 (GRCm39) nonsense probably null
R1823:Grm7 UTSW 6 111,184,730 (GRCm39) missense probably benign 0.17
R1864:Grm7 UTSW 6 111,057,384 (GRCm39) missense probably benign 0.03
R1894:Grm7 UTSW 6 111,335,568 (GRCm39) missense probably benign
R1987:Grm7 UTSW 6 110,891,472 (GRCm39) missense probably damaging 1.00
R1993:Grm7 UTSW 6 111,184,769 (GRCm39) missense probably benign 0.13
R2138:Grm7 UTSW 6 110,623,098 (GRCm39) missense probably damaging 1.00
R2214:Grm7 UTSW 6 111,335,958 (GRCm39) missense probably damaging 1.00
R2289:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2296:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2339:Grm7 UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
R2847:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2849:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2879:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2884:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2921:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R2923:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R3014:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3015:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3703:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3713:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4009:Grm7 UTSW 6 111,472,683 (GRCm39) missense probably damaging 1.00
R4091:Grm7 UTSW 6 110,891,301 (GRCm39) missense probably damaging 1.00
R4131:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4132:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4161:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 0.99
R4329:Grm7 UTSW 6 110,891,325 (GRCm39) missense probably damaging 1.00
R4357:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4359:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4379:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4379:Grm7 UTSW 6 111,223,335 (GRCm39) missense probably benign 0.05
R4380:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4514:Grm7 UTSW 6 111,335,265 (GRCm39) missense possibly damaging 0.81
R4518:Grm7 UTSW 6 110,891,507 (GRCm39) splice site probably null
R4647:Grm7 UTSW 6 110,891,344 (GRCm39) nonsense probably null
R4714:Grm7 UTSW 6 111,057,383 (GRCm39) missense possibly damaging 0.52
R4775:Grm7 UTSW 6 110,891,332 (GRCm39) missense probably damaging 1.00
R4957:Grm7 UTSW 6 111,335,824 (GRCm39) missense probably damaging 1.00
R5056:Grm7 UTSW 6 111,057,404 (GRCm39) missense probably damaging 0.99
R5062:Grm7 UTSW 6 110,623,097 (GRCm39) missense probably damaging 1.00
R5256:Grm7 UTSW 6 111,335,182 (GRCm39) missense probably benign 0.01
R5431:Grm7 UTSW 6 111,335,387 (GRCm39) missense probably benign
R6026:Grm7 UTSW 6 111,478,500 (GRCm39) nonsense probably null
R6174:Grm7 UTSW 6 111,223,258 (GRCm39) missense probably benign
R6305:Grm7 UTSW 6 111,335,626 (GRCm39) missense probably damaging 1.00
R6318:Grm7 UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
R6440:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 1.00
R6519:Grm7 UTSW 6 111,184,713 (GRCm39) missense probably benign 0.00
R6531:Grm7 UTSW 6 111,335,386 (GRCm39) missense probably benign 0.29
R6888:Grm7 UTSW 6 111,335,314 (GRCm39) missense possibly damaging 0.79
R6949:Grm7 UTSW 6 111,472,690 (GRCm39) missense probably damaging 1.00
R6949:Grm7 UTSW 6 110,623,265 (GRCm39) missense probably benign 0.03
R6989:Grm7 UTSW 6 111,184,766 (GRCm39) missense probably damaging 1.00
R7076:Grm7 UTSW 6 111,335,113 (GRCm39) missense probably benign 0.04
R7203:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7208:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7217:Grm7 UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
R7257:Grm7 UTSW 6 110,623,079 (GRCm39) missense probably damaging 1.00
R7297:Grm7 UTSW 6 110,622,974 (GRCm39) missense probably benign 0.16
R7470:Grm7 UTSW 6 111,478,476 (GRCm39) missense
R7567:Grm7 UTSW 6 111,335,722 (GRCm39) missense probably damaging 0.96
R7806:Grm7 UTSW 6 111,223,314 (GRCm39) nonsense probably null
R8018:Grm7 UTSW 6 111,184,737 (GRCm39) missense probably benign 0.01
R8076:Grm7 UTSW 6 111,543,000 (GRCm39) missense probably damaging 1.00
R8409:Grm7 UTSW 6 110,891,297 (GRCm39) missense probably benign 0.02
R8420:Grm7 UTSW 6 111,057,315 (GRCm39) missense probably benign
R8523:Grm7 UTSW 6 111,223,280 (GRCm39) missense possibly damaging 0.76
R8816:Grm7 UTSW 6 111,230,966 (GRCm39) missense possibly damaging 0.46
R8958:Grm7 UTSW 6 111,472,783 (GRCm39) missense probably damaging 0.96
R9135:Grm7 UTSW 6 111,472,729 (GRCm39) missense probably benign 0.39
R9207:Grm7 UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
R9210:Grm7 UTSW 6 110,622,869 (GRCm39) missense probably benign 0.01
R9438:Grm7 UTSW 6 111,231,077 (GRCm39) missense possibly damaging 0.94
R9448:Grm7 UTSW 6 111,335,193 (GRCm39) missense probably benign 0.01
Z1176:Grm7 UTSW 6 111,335,451 (GRCm39) missense probably damaging 1.00
Z1176:Grm7 UTSW 6 111,335,110 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCTCTCGACCAGATCAACAG -3'
(R):5'- GATTCGACAGGATCTCCAGG -3'

Sequencing Primer
(F):5'- TGCTGCCCAACGTAACG -3'
(R):5'- ATCTCCAGGGTAGAAATGTTGG -3'
Posted On 2015-04-29