Incidental Mutation 'R3965:Trbv5'
ID 312301
Institutional Source Beutler Lab
Gene Symbol Trbv5
Ensembl Gene ENSMUSG00000076465
Gene Name T cell receptor beta, variable 5
Synonyms Tcrb-V1
MMRRC Submission 040934-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R3965 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 41039293-41039737 bp(+) (GRCm39)
Type of Mutation critical splice donor site
DNA Base Change (assembly) G to T at 41039342 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000100082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103265] [ENSMUST00000103266]
AlphaFold A0A0B4J1G9
Predicted Effect probably benign
Transcript: ENSMUST00000103265
SMART Domains Protein: ENSMUSP00000100081
Gene: ENSMUSG00000076464

DomainStartEndE-ValueType
IG 27 113 3.54e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103265
SMART Domains Protein: ENSMUSP00000144909
Gene: ENSMUSG00000107486

DomainStartEndE-ValueType
IG 27 113 3.54e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103266
SMART Domains Protein: ENSMUSP00000100082
Gene: ENSMUSG00000076465

DomainStartEndE-ValueType
Pfam:V-set 20 113 5.9e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192753
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193357
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193743
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (49/49)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
C1galt1c1 A T X: 37,720,453 (GRCm39) V181E probably benign Het
Ccdc121 T A 5: 31,645,335 (GRCm39) C363S probably benign Het
Cep70 T A 9: 99,180,587 (GRCm39) F581I probably damaging Het
Cfap74 T A 4: 155,531,174 (GRCm39) M809K probably damaging Het
Clic6 T C 16: 92,295,732 (GRCm39) S131P probably benign Het
Ctc1 T A 11: 68,921,954 (GRCm39) V800D probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dlec1 A G 9: 118,957,649 (GRCm39) I878V probably benign Het
Elapor1 T C 3: 108,365,765 (GRCm39) D998G probably damaging Het
Esyt3 T A 9: 99,202,375 (GRCm39) D512V probably damaging Het
Ewsr1 T C 11: 5,033,476 (GRCm39) Y232C unknown Het
Exoc2 G A 13: 31,061,565 (GRCm39) S492L probably benign Het
Gprc6a CAAA CA 10: 51,491,776 (GRCm39) probably null Het
Grin2c G A 11: 115,151,820 (GRCm39) R47W probably damaging Het
Igfn1 T C 1: 135,895,557 (GRCm39) T1670A probably benign Het
Med31 C T 11: 72,102,755 (GRCm39) A118T probably benign Het
Mia2 T A 12: 59,223,158 (GRCm39) S489T probably damaging Het
Mov10l1 A G 15: 88,896,366 (GRCm39) I737V probably benign Het
Muc2 G A 7: 141,286,233 (GRCm39) R120H probably benign Het
Nckap1l T A 15: 103,373,016 (GRCm39) C276* probably null Het
Nrap T C 19: 56,330,576 (GRCm39) S1126G probably damaging Het
Oas1c A G 5: 120,946,783 (GRCm39) F16L probably damaging Het
Or10g9 A T 9: 39,911,767 (GRCm39) V252E possibly damaging Het
Or1ab2 G A 8: 72,864,108 (GRCm39) G233R probably damaging Het
Or5b123 T C 19: 13,596,565 (GRCm39) L13P probably damaging Het
Or8b51 G A 9: 38,569,023 (GRCm39) L222F probably benign Het
Pik3c2g A G 6: 139,801,018 (GRCm39) M388V possibly damaging Het
Pls1 T C 9: 95,667,665 (GRCm39) Q81R probably benign Het
Pole A G 5: 110,460,648 (GRCm39) K1143E probably damaging Het
Ppp6r2 A G 15: 89,143,317 (GRCm39) K155E probably benign Het
Rxra T A 2: 27,642,318 (GRCm39) probably benign Het
Susd5 A G 9: 113,925,260 (GRCm39) E381G possibly damaging Het
Svs5 T C 2: 164,079,662 (GRCm39) T82A possibly damaging Het
Syt14 A T 1: 192,584,175 (GRCm39) H413Q probably benign Het
Tg T A 15: 66,556,039 (GRCm39) D910E probably benign Het
Timd5 T A 11: 46,426,340 (GRCm39) V149D possibly damaging Het
Tpcn1 G T 5: 120,694,640 (GRCm39) T143K probably damaging Het
Trhr T A 15: 44,061,095 (GRCm39) I205N possibly damaging Het
Trp73 A G 4: 154,146,493 (GRCm39) V422A probably benign Het
Trpc6 G A 9: 8,626,622 (GRCm39) C324Y probably damaging Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Zfhx4 G T 3: 5,468,907 (GRCm39) V3022F probably damaging Het
Zswim8 G A 14: 20,763,141 (GRCm39) V347I probably benign Het
Other mutations in Trbv5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2508:Trbv5 UTSW 6 41,039,555 (GRCm39) nonsense probably null
R3845:Trbv5 UTSW 6 41,039,682 (GRCm39) missense probably benign 0.03
R5256:Trbv5 UTSW 6 41,039,318 (GRCm39) missense possibly damaging 0.87
R6773:Trbv5 UTSW 6 41,039,551 (GRCm39) missense probably damaging 1.00
R7582:Trbv5 UTSW 6 41,039,617 (GRCm39) missense probably benign 0.00
R8066:Trbv5 UTSW 6 41,039,326 (GRCm39) missense probably damaging 0.96
R8441:Trbv5 UTSW 6 41,039,517 (GRCm39) missense probably damaging 1.00
R8947:Trbv5 UTSW 6 41,039,641 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCCAGCCCAGTGAATTCAG -3'
(R):5'- GCTCACATTCCAAAGACTTATTTGC -3'

Sequencing Primer
(F):5'- GCCCAGTGAATTCAGTTGAC -3'
(R):5'- AAAGACTTATTTGCTCTTCCCAGG -3'
Posted On 2015-04-29