Incidental Mutation 'R3965:Or10g9'
ID 312308
Institutional Source Beutler Lab
Gene Symbol Or10g9
Ensembl Gene ENSMUSG00000059473
Gene Name olfactory receptor family 10 subfamily G member 9
Synonyms MOR223-1, Olfr979, GA_x6K02T2PVTD-33699706-33698771
MMRRC Submission 040934-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R3965 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39911502-39912546 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39911767 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 252 (V252E)
Ref Sequence ENSEMBL: ENSMUSP00000148903 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080835] [ENSMUST00000215523] [ENSMUST00000216463]
AlphaFold Q8VH10
Predicted Effect possibly damaging
Transcript: ENSMUST00000080835
AA Change: V252E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000079648
Gene: ENSMUSG00000059473
AA Change: V252E

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 7.9e-58 PFAM
Pfam:7tm_1 39 287 5.2e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215523
AA Change: V252E

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000216463
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
C1galt1c1 A T X: 37,720,453 (GRCm39) V181E probably benign Het
Ccdc121 T A 5: 31,645,335 (GRCm39) C363S probably benign Het
Cep70 T A 9: 99,180,587 (GRCm39) F581I probably damaging Het
Cfap74 T A 4: 155,531,174 (GRCm39) M809K probably damaging Het
Clic6 T C 16: 92,295,732 (GRCm39) S131P probably benign Het
Ctc1 T A 11: 68,921,954 (GRCm39) V800D probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dlec1 A G 9: 118,957,649 (GRCm39) I878V probably benign Het
Elapor1 T C 3: 108,365,765 (GRCm39) D998G probably damaging Het
Esyt3 T A 9: 99,202,375 (GRCm39) D512V probably damaging Het
Ewsr1 T C 11: 5,033,476 (GRCm39) Y232C unknown Het
Exoc2 G A 13: 31,061,565 (GRCm39) S492L probably benign Het
Gprc6a CAAA CA 10: 51,491,776 (GRCm39) probably null Het
Grin2c G A 11: 115,151,820 (GRCm39) R47W probably damaging Het
Igfn1 T C 1: 135,895,557 (GRCm39) T1670A probably benign Het
Med31 C T 11: 72,102,755 (GRCm39) A118T probably benign Het
Mia2 T A 12: 59,223,158 (GRCm39) S489T probably damaging Het
Mov10l1 A G 15: 88,896,366 (GRCm39) I737V probably benign Het
Muc2 G A 7: 141,286,233 (GRCm39) R120H probably benign Het
Nckap1l T A 15: 103,373,016 (GRCm39) C276* probably null Het
Nrap T C 19: 56,330,576 (GRCm39) S1126G probably damaging Het
Oas1c A G 5: 120,946,783 (GRCm39) F16L probably damaging Het
Or1ab2 G A 8: 72,864,108 (GRCm39) G233R probably damaging Het
Or5b123 T C 19: 13,596,565 (GRCm39) L13P probably damaging Het
Or8b51 G A 9: 38,569,023 (GRCm39) L222F probably benign Het
Pik3c2g A G 6: 139,801,018 (GRCm39) M388V possibly damaging Het
Pls1 T C 9: 95,667,665 (GRCm39) Q81R probably benign Het
Pole A G 5: 110,460,648 (GRCm39) K1143E probably damaging Het
Ppp6r2 A G 15: 89,143,317 (GRCm39) K155E probably benign Het
Rxra T A 2: 27,642,318 (GRCm39) probably benign Het
Susd5 A G 9: 113,925,260 (GRCm39) E381G possibly damaging Het
Svs5 T C 2: 164,079,662 (GRCm39) T82A possibly damaging Het
Syt14 A T 1: 192,584,175 (GRCm39) H413Q probably benign Het
Tg T A 15: 66,556,039 (GRCm39) D910E probably benign Het
Timd5 T A 11: 46,426,340 (GRCm39) V149D possibly damaging Het
Tpcn1 G T 5: 120,694,640 (GRCm39) T143K probably damaging Het
Trbv5 G T 6: 41,039,342 (GRCm39) probably benign Het
Trhr T A 15: 44,061,095 (GRCm39) I205N possibly damaging Het
Trp73 A G 4: 154,146,493 (GRCm39) V422A probably benign Het
Trpc6 G A 9: 8,626,622 (GRCm39) C324Y probably damaging Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Zfhx4 G T 3: 5,468,907 (GRCm39) V3022F probably damaging Het
Zswim8 G A 14: 20,763,141 (GRCm39) V347I probably benign Het
Other mutations in Or10g9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02718:Or10g9 APN 9 39,912,182 (GRCm39) missense probably damaging 1.00
IGL02939:Or10g9 APN 9 39,912,194 (GRCm39) missense probably benign 0.26
IGL02991:Or10g9 UTSW 9 39,911,698 (GRCm39) missense probably damaging 1.00
R1388:Or10g9 UTSW 9 39,911,948 (GRCm39) missense probably damaging 0.99
R1572:Or10g9 UTSW 9 39,912,490 (GRCm39) missense probably benign 0.35
R2089:Or10g9 UTSW 9 39,912,500 (GRCm39) missense probably benign 0.01
R2091:Or10g9 UTSW 9 39,912,500 (GRCm39) missense probably benign 0.01
R2091:Or10g9 UTSW 9 39,912,500 (GRCm39) missense probably benign 0.01
R2179:Or10g9 UTSW 9 39,912,220 (GRCm39) missense probably benign 0.44
R3424:Or10g9 UTSW 9 39,911,830 (GRCm39) missense probably damaging 0.97
R3964:Or10g9 UTSW 9 39,911,767 (GRCm39) missense possibly damaging 0.95
R4111:Or10g9 UTSW 9 39,912,194 (GRCm39) nonsense probably null
R4537:Or10g9 UTSW 9 39,911,616 (GRCm39) missense probably benign 0.01
R4737:Or10g9 UTSW 9 39,911,718 (GRCm39) missense probably damaging 0.96
R4926:Or10g9 UTSW 9 39,912,319 (GRCm39) splice site probably null
R5303:Or10g9 UTSW 9 39,911,884 (GRCm39) missense probably damaging 1.00
R5587:Or10g9 UTSW 9 39,911,917 (GRCm39) missense possibly damaging 0.90
R6387:Or10g9 UTSW 9 39,912,148 (GRCm39) missense probably damaging 0.99
R6394:Or10g9 UTSW 9 39,912,001 (GRCm39) missense probably benign 0.04
R6765:Or10g9 UTSW 9 39,912,493 (GRCm39) missense probably damaging 1.00
R7312:Or10g9 UTSW 9 39,912,106 (GRCm39) missense probably benign 0.22
R7463:Or10g9 UTSW 9 39,911,860 (GRCm39) missense probably benign 0.07
R7486:Or10g9 UTSW 9 39,912,181 (GRCm39) missense probably benign 0.39
R7581:Or10g9 UTSW 9 39,911,718 (GRCm39) missense probably damaging 0.96
R8364:Or10g9 UTSW 9 39,911,660 (GRCm39) missense probably benign 0.22
R8414:Or10g9 UTSW 9 39,912,241 (GRCm39) missense probably benign 0.19
R9049:Or10g9 UTSW 9 39,911,919 (GRCm39) missense possibly damaging 0.56
R9567:Or10g9 UTSW 9 39,912,367 (GRCm39) missense possibly damaging 0.95
R9632:Or10g9 UTSW 9 39,912,172 (GRCm39) missense probably damaging 1.00
R9710:Or10g9 UTSW 9 39,912,172 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTTACTGGCTCTGAGAATATGC -3'
(R):5'- AGCATTATTTCTGTGATGCACCTC -3'

Sequencing Primer
(F):5'- ACTGGCTCTGAGAATATGCTACTTTG -3'
(R):5'- TCAGCCAATGAGATGGTCATC -3'
Posted On 2015-04-29