|Institutional Source||Beutler Lab|
|Gene Name||sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3968 (G1)|
|Chromosomal Location||31217860-31230352 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 31226521 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000087643 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000090180]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.636|
|Coding Region Coverage||
|Validation Efficiency||98% (40/41)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lymphatic branching complexity with decreased lymphatic width. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sema3g||
(F):5'- TAGTTCCCTTGCTGACCTGG -3'
(R):5'- GCGTTAGCATAGGAACCTTCC -3'
(F):5'- GGCCTGATCCTCTCTACAGAAG -3'
(R):5'- ATCCCCCTCACAGAGTAGGGAG -3'