Incidental Mutation 'R3968:Or4n5'
ID 312455
Institutional Source Beutler Lab
Gene Symbol Or4n5
Ensembl Gene ENSMUSG00000048933
Gene Name olfactory receptor family 4 subfamily N member 5
Synonyms GA_x6K02T2PMLR-5566715-5565789, MOR241-3, Olfr722
MMRRC Submission 040936-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R3968 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50131715-50139398 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50132983 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 92 (I92N)
Ref Sequence ENSEMBL: ENSMUSP00000059721 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053290]
AlphaFold Q8VFC8
Predicted Effect probably damaging
Transcript: ENSMUST00000053290
AA Change: I92N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000059721
Gene: ENSMUSG00000048933
AA Change: I92N

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 4.3e-44 PFAM
Pfam:7tm_1 41 288 2.5e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213271
Meta Mutation Damage Score 0.4688 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.1%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef12 C A 9: 42,916,847 (GRCm39) R432L probably damaging Het
Camk4 T A 18: 33,312,634 (GRCm39) I258N possibly damaging Het
Cdhr2 A T 13: 54,874,271 (GRCm39) N781I probably damaging Het
Cela1 C T 15: 100,582,534 (GRCm39) G93S probably damaging Het
Commd9 C A 2: 101,727,486 (GRCm39) N93K probably benign Het
Cysltr2 A G 14: 73,267,614 (GRCm39) I32T probably damaging Het
E2f1 C G 2: 154,405,942 (GRCm39) G144R probably damaging Het
Fcho2 A T 13: 98,871,564 (GRCm39) S551T probably benign Het
Fzd8 T C 18: 9,214,070 (GRCm39) V384A probably damaging Het
Gm14401 T C 2: 176,778,789 (GRCm39) Y292H possibly damaging Het
H2-M2 C T 17: 37,792,197 (GRCm39) G318S possibly damaging Het
Il21r G T 7: 125,227,215 (GRCm39) probably null Het
Itgam T C 7: 127,712,205 (GRCm39) Y697H probably damaging Het
Itpkb A T 1: 180,155,363 (GRCm39) probably benign Het
Lama3 A T 18: 12,713,398 (GRCm39) K3230M probably damaging Het
Ly75 T C 2: 60,158,217 (GRCm39) I1023V possibly damaging Het
Narf A T 11: 121,129,247 (GRCm39) E10D possibly damaging Het
Net1 A G 13: 3,957,795 (GRCm39) probably null Het
Nlrx1 A T 9: 44,166,722 (GRCm39) probably benign Het
Oard1 T C 17: 48,722,282 (GRCm39) Y93H probably damaging Het
Or8b54 A G 9: 38,686,664 (GRCm39) T38A probably benign Het
Pcm1 T C 8: 41,778,867 (GRCm39) L1825P probably damaging Het
Pecr G A 1: 72,315,468 (GRCm39) T94I probably damaging Het
Piezo2 A T 18: 63,144,767 (GRCm39) V2776E probably damaging Het
Pik3r2 G A 8: 71,223,065 (GRCm39) R452C probably benign Het
Ppfia2 T A 10: 106,742,382 (GRCm39) D1058E probably damaging Het
Ppl T C 16: 4,918,196 (GRCm39) probably null Het
Rab39 G A 9: 53,597,932 (GRCm39) A111V possibly damaging Het
Sema3g T C 14: 30,948,478 (GRCm39) probably null Het
Slc19a1 T C 10: 76,877,680 (GRCm39) Y72H probably damaging Het
Sntb2 T A 8: 107,723,772 (GRCm39) Y340* probably null Het
Srrm4 A G 5: 116,582,803 (GRCm39) probably benign Het
Ssb C T 2: 69,697,793 (GRCm39) probably benign Het
Sval2 T A 6: 41,838,861 (GRCm39) V14E probably damaging Het
Tmc2 T G 2: 130,043,991 (GRCm39) V75G probably benign Het
Tnnc2 T C 2: 164,619,457 (GRCm39) E129G possibly damaging Het
Vmn2r94 C A 17: 18,478,647 (GRCm39) Q33H possibly damaging Het
Yap1 C T 9: 7,973,877 (GRCm39) R188Q probably damaging Het
Other mutations in Or4n5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1229:Or4n5 UTSW 14 50,132,711 (GRCm39) nonsense probably null
R1400:Or4n5 UTSW 14 50,133,148 (GRCm39) missense possibly damaging 0.49
R1417:Or4n5 UTSW 14 50,133,020 (GRCm39) nonsense probably null
R2126:Or4n5 UTSW 14 50,132,524 (GRCm39) missense probably benign 0.01
R4008:Or4n5 UTSW 14 50,132,464 (GRCm39) missense probably benign 0.00
R4032:Or4n5 UTSW 14 50,132,433 (GRCm39) missense probably benign 0.22
R4409:Or4n5 UTSW 14 50,133,230 (GRCm39) missense probably benign 0.01
R4934:Or4n5 UTSW 14 50,133,206 (GRCm39) missense probably benign 0.00
R5110:Or4n5 UTSW 14 50,133,032 (GRCm39) missense possibly damaging 0.49
R5232:Or4n5 UTSW 14 50,133,155 (GRCm39) missense probably damaging 1.00
R7019:Or4n5 UTSW 14 50,133,124 (GRCm39) missense probably damaging 1.00
R8963:Or4n5 UTSW 14 50,132,509 (GRCm39) missense probably benign 0.27
R9188:Or4n5 UTSW 14 50,132,366 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTACAATGGAATGAGCAAAACCC -3'
(R):5'- AACTCCTGGTCTTCGCACTG -3'

Sequencing Primer
(F):5'- TGGAATGAGCAAAACCCCCAAG -3'
(R):5'- ACTCCTGGTCTTCGCACTGATTTC -3'
Posted On 2015-04-29