Incidental Mutation 'R3974:Veph1'
ID 312510
Institutional Source Beutler Lab
Gene Symbol Veph1
Ensembl Gene ENSMUSG00000027831
Gene Name ventricular zone expressed PH domain-containing 1
Synonyms 2810471M23Rik, Veph
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3974 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 65960979-66204258 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 66065648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 473 (M473K)
Ref Sequence ENSEMBL: ENSMUSP00000029419 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029419]
AlphaFold A1A535
Predicted Effect probably benign
Transcript: ENSMUST00000029419
AA Change: M473K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000029419
Gene: ENSMUSG00000027831
AA Change: M473K

DomainStartEndE-ValueType
low complexity region 59 76 N/A INTRINSIC
Blast:PH 586 626 1e-5 BLAST
PH 717 821 1.44e-14 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a disruption in this gene appear normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik T C 4: 148,029,488 (GRCm39) I486T probably damaging Het
Abca8a A T 11: 109,974,328 (GRCm39) M202K probably damaging Het
Abhd4 T A 14: 54,500,417 (GRCm39) I117N probably damaging Het
Adam23 T A 1: 63,586,888 (GRCm39) Y416* probably null Het
Cenpe A G 3: 134,940,986 (GRCm39) probably null Het
Cenph A G 13: 100,900,075 (GRCm39) V151A probably damaging Het
Cfap54 A G 10: 92,675,333 (GRCm39) S2863P possibly damaging Het
Clca3a1 A T 3: 144,738,400 (GRCm39) V36D probably damaging Het
Cnbd1 G A 4: 18,887,693 (GRCm39) R274C probably benign Het
Crot T C 5: 9,027,541 (GRCm39) T264A probably benign Het
Dll4 A G 2: 119,164,573 (GRCm39) D664G probably damaging Het
Ehbp1 C T 11: 22,087,867 (GRCm39) A406T probably benign Het
Far2 T A 6: 148,052,252 (GRCm39) I177N probably damaging Het
Flt4 T G 11: 49,527,567 (GRCm39) V910G probably damaging Het
Fmod A G 1: 133,968,496 (GRCm39) R179G probably benign Het
Gdf2 T A 14: 33,666,791 (GRCm39) V171D probably damaging Het
Gpx6 C A 13: 21,501,828 (GRCm39) S150Y probably damaging Het
Grik2 A T 10: 49,298,750 (GRCm39) Y37N probably damaging Het
Grn T C 11: 102,327,165 (GRCm39) V559A probably damaging Het
Lrrc37 A T 11: 103,509,927 (GRCm39) probably benign Het
Muc2 T A 7: 141,300,541 (GRCm39) probably benign Het
Myo5b T C 18: 74,767,552 (GRCm39) Y287H probably damaging Het
Nbeal2 T C 9: 110,462,914 (GRCm39) T1350A probably damaging Het
Nfkbiz T C 16: 55,638,799 (GRCm39) I220M probably benign Het
Nt5dc2 T C 14: 30,860,832 (GRCm39) S439P probably damaging Het
Omg T A 11: 79,393,224 (GRCm39) E211D probably benign Het
Or52ab7 T G 7: 102,978,285 (GRCm39) D197E probably damaging Het
Or8k18 A T 2: 86,085,935 (GRCm39) I34N possibly damaging Het
Pcdhb4 A G 18: 37,441,901 (GRCm39) T404A possibly damaging Het
Plcl1 T A 1: 55,737,374 (GRCm39) M905K probably benign Het
Plod2 G T 9: 92,480,672 (GRCm39) G422* probably null Het
Ppp1r12a T C 10: 108,089,341 (GRCm39) V660A probably benign Het
Prdm6 T C 18: 53,673,278 (GRCm39) I186T possibly damaging Het
Ptprq T G 10: 107,547,923 (GRCm39) K158N possibly damaging Het
Rimbp2 A G 5: 128,874,862 (GRCm39) V243A probably damaging Het
Rp1l1 T A 14: 64,267,758 (GRCm39) Y1115N probably damaging Het
Rtn4 C T 11: 29,657,505 (GRCm39) T553I probably damaging Het
Scrn3 T C 2: 73,166,121 (GRCm39) S385P possibly damaging Het
Serpina1f C A 12: 103,659,830 (GRCm39) G151* probably null Het
Sis T C 3: 72,850,968 (GRCm39) T577A probably damaging Het
Slco1a1 A T 6: 141,854,819 (GRCm39) S611T probably benign Het
Smad4 G T 18: 73,810,807 (GRCm39) T59K possibly damaging Het
Syne1 T C 10: 4,993,630 (GRCm39) D8370G probably benign Het
Tigd4 G A 3: 84,502,585 (GRCm39) A501T possibly damaging Het
Tjp1 A T 7: 64,947,387 (GRCm39) C1724* probably null Het
Tmem107 G T 11: 68,962,301 (GRCm39) probably null Het
Tsc22d1 T C 14: 76,656,049 (GRCm39) S761P probably damaging Het
Tyw5 A T 1: 57,430,687 (GRCm39) D165E probably damaging Het
U2af2 T A 7: 5,072,438 (GRCm39) probably null Het
Ube3b T A 5: 114,550,491 (GRCm39) D839E probably benign Het
Ush2a A G 1: 188,113,698 (GRCm39) D639G probably benign Het
Vmn2r72 A T 7: 85,399,017 (GRCm39) N445K probably damaging Het
Vps37d T C 5: 135,105,393 (GRCm39) M77V probably null Het
Other mutations in Veph1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00755:Veph1 APN 3 66,162,431 (GRCm39) missense probably damaging 1.00
IGL01539:Veph1 APN 3 66,065,496 (GRCm39) missense probably benign 0.00
IGL01746:Veph1 APN 3 66,065,508 (GRCm39) missense probably benign
IGL02055:Veph1 APN 3 66,113,048 (GRCm39) missense possibly damaging 0.94
IGL02504:Veph1 APN 3 66,079,551 (GRCm39) missense probably damaging 1.00
IGL02610:Veph1 APN 3 66,079,588 (GRCm39) missense probably damaging 1.00
IGL02647:Veph1 APN 3 66,066,869 (GRCm39) splice site probably benign
IGL03279:Veph1 APN 3 66,162,443 (GRCm39) missense probably damaging 1.00
R0317:Veph1 UTSW 3 66,079,396 (GRCm39) missense probably benign
R0318:Veph1 UTSW 3 65,964,680 (GRCm39) missense probably damaging 1.00
R0418:Veph1 UTSW 3 66,162,449 (GRCm39) nonsense probably null
R1913:Veph1 UTSW 3 66,151,976 (GRCm39) missense probably damaging 1.00
R2081:Veph1 UTSW 3 65,968,523 (GRCm39) missense probably damaging 1.00
R2116:Veph1 UTSW 3 65,964,610 (GRCm39) missense probably benign 0.06
R3622:Veph1 UTSW 3 66,122,858 (GRCm39) missense probably benign 0.01
R3623:Veph1 UTSW 3 66,122,858 (GRCm39) missense probably benign 0.01
R3624:Veph1 UTSW 3 66,122,858 (GRCm39) missense probably benign 0.01
R3829:Veph1 UTSW 3 66,066,748 (GRCm39) missense possibly damaging 0.92
R3862:Veph1 UTSW 3 66,162,313 (GRCm39) missense probably damaging 1.00
R4209:Veph1 UTSW 3 66,151,967 (GRCm39) missense probably damaging 1.00
R4361:Veph1 UTSW 3 66,066,737 (GRCm39) missense probably benign 0.00
R4416:Veph1 UTSW 3 65,968,606 (GRCm39) missense probably damaging 0.99
R5478:Veph1 UTSW 3 66,162,443 (GRCm39) missense probably damaging 1.00
R6218:Veph1 UTSW 3 66,162,481 (GRCm39) missense probably damaging 1.00
R6399:Veph1 UTSW 3 66,033,312 (GRCm39) missense probably benign 0.03
R6655:Veph1 UTSW 3 66,113,034 (GRCm39) missense possibly damaging 0.50
R6867:Veph1 UTSW 3 66,162,458 (GRCm39) missense probably damaging 1.00
R6877:Veph1 UTSW 3 66,162,505 (GRCm39) missense probably damaging 1.00
R7257:Veph1 UTSW 3 66,065,703 (GRCm39) missense probably benign 0.00
R7723:Veph1 UTSW 3 66,113,093 (GRCm39) missense possibly damaging 0.95
R7969:Veph1 UTSW 3 66,122,896 (GRCm39) missense possibly damaging 0.81
R8174:Veph1 UTSW 3 66,171,316 (GRCm39) missense probably damaging 1.00
R8526:Veph1 UTSW 3 66,066,737 (GRCm39) missense probably benign 0.00
R8816:Veph1 UTSW 3 66,065,646 (GRCm39) missense probably benign
R8946:Veph1 UTSW 3 66,171,301 (GRCm39) critical splice donor site probably null
R9342:Veph1 UTSW 3 66,151,959 (GRCm39) missense probably damaging 0.97
R9411:Veph1 UTSW 3 65,995,238 (GRCm39) missense possibly damaging 0.95
R9461:Veph1 UTSW 3 66,029,066 (GRCm39) missense probably benign
R9658:Veph1 UTSW 3 66,171,434 (GRCm39) nonsense probably null
X0025:Veph1 UTSW 3 66,151,917 (GRCm39) missense probably benign
Z1176:Veph1 UTSW 3 66,151,909 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATAGGACTTGTGGCTGCCTCTAG -3'
(R):5'- CAGTGTCTCAGTCTGGTGGAAG -3'

Sequencing Primer
(F):5'- GACTTGTGGCTGCCTCTAGAATTTC -3'
(R):5'- CTGGTGGAAGCAAATTTTTGTCC -3'
Posted On 2015-04-30