Incidental Mutation 'R3976:Olfr267'
ID312631
Institutional Source Beutler Lab
Gene Symbol Olfr267
Ensembl Gene ENSMUSG00000043385
Gene Nameolfactory receptor 267
SynonymsMOR262-1, GA_x6K02T2N78B-1272842-1273783
MMRRC Submission 040842-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.107) question?
Stock #R3976 (G1)
Quality Score225
Status Validated
Chromosome4
Chromosomal Location58782704-58787716 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 58785164 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 186 (L186P)
Ref Sequence ENSEMBL: ENSMUSP00000150848 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059608] [ENSMUST00000216719]
Predicted Effect probably damaging
Transcript: ENSMUST00000059608
AA Change: L186P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062002
Gene: ENSMUSG00000043385
AA Change: L186P

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4e-51 PFAM
Pfam:7tm_1 41 289 5.2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216719
AA Change: L186P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.0296 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency 98% (49/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik A T 17: 33,066,431 S466T probably benign Het
Abca9 T C 11: 110,148,789 D466G probably benign Het
Asb4 A T 6: 5,390,771 M55L probably benign Het
Atxn7l1 T C 12: 33,325,955 S10P probably damaging Het
Bola3 T C 6: 83,351,267 L45P probably benign Het
Cacna2d4 A G 6: 119,278,173 probably null Het
Cfap54 A G 10: 92,839,471 S2863P possibly damaging Het
Cyb5r3 A G 15: 83,160,129 V180A possibly damaging Het
Dglucy A T 12: 100,841,389 T186S probably benign Het
Eml5 A T 12: 98,802,465 probably benign Het
Fam90a1a G A 8: 21,961,416 D98N probably damaging Het
Fbxo16 T A 14: 65,287,157 L42Q probably damaging Het
Fbxw16 A G 9: 109,439,629 V231A probably benign Het
Fermt3 G A 19: 7,002,424 A447V possibly damaging Het
Fignl2 A G 15: 101,052,586 L605P unknown Het
Gcsam T G 16: 45,619,829 N78K probably damaging Het
Gdf2 T A 14: 33,944,834 V171D probably damaging Het
Gm28042 C T 2: 120,036,756 H218Y probably benign Het
Gm9825 A T 6: 7,983,149 noncoding transcript Het
Herpud2 A G 9: 25,110,438 V304A probably damaging Het
Kcnma1 C T 14: 24,003,747 probably null Het
Lrp3 T C 7: 35,204,105 D251G probably benign Het
Mapkbp1 T C 2: 120,021,858 V957A possibly damaging Het
Mepe C T 5: 104,337,078 P28L probably benign Het
Muc2 T A 7: 141,746,804 probably benign Het
Nt5dc2 T C 14: 31,138,875 S439P probably damaging Het
Olfr1306 C T 2: 111,912,606 G108D possibly damaging Het
Opn4 C T 14: 34,597,109 R173H probably benign Het
Ppp1r12a T C 10: 108,253,480 V660A probably benign Het
Prdm6 T C 18: 53,540,206 I186T possibly damaging Het
Rab18 T A 18: 6,778,529 D53E probably benign Het
Rel A G 11: 23,742,939 S365P probably benign Het
Rhbg C A 3: 88,244,536 G383V probably damaging Het
Rp1l1 T A 14: 64,030,309 Y1115N probably damaging Het
Runx2 T C 17: 44,610,079 T339A possibly damaging Het
Ryr3 T C 2: 112,675,837 E3455G possibly damaging Het
Serpina1d A T 12: 103,767,848 S66T probably benign Het
Setd3 T C 12: 108,165,158 K3R possibly damaging Het
Spg7 A G 8: 123,079,448 D299G probably damaging Het
Sptbn5 C T 2: 120,048,261 noncoding transcript Het
Srcap A G 7: 127,549,239 T1859A probably benign Het
Suox A G 10: 128,671,037 V374A probably damaging Het
Tesk1 C T 4: 43,445,786 P280S possibly damaging Het
Tsc22d1 T C 14: 76,418,609 S761P probably damaging Het
Tubal3 C T 13: 3,932,946 S242L probably benign Het
Ugt2b1 C A 5: 86,917,675 V502L probably benign Het
Other mutations in Olfr267
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01687:Olfr267 APN 4 58785047 missense probably damaging 1.00
R0281:Olfr267 UTSW 4 58784981 missense probably damaging 1.00
R0282:Olfr267 UTSW 4 58785344 missense probably damaging 1.00
R1017:Olfr267 UTSW 4 58785115 missense probably damaging 0.98
R1843:Olfr267 UTSW 4 58785384 missense probably benign
R4368:Olfr267 UTSW 4 58785153 missense probably benign 0.00
R5545:Olfr267 UTSW 4 58785585 missense probably benign 0.08
R5659:Olfr267 UTSW 4 58785672 missense probably damaging 1.00
R5668:Olfr267 UTSW 4 58785489 missense probably benign 0.00
R6186:Olfr267 UTSW 4 58784948 missense probably damaging 1.00
R6925:Olfr267 UTSW 4 58785647 missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- CAAGTGTGCACCACAGGTTG -3'
(R):5'- CAGAGTGTATACTTCTGGCGG -3'

Sequencing Primer
(F):5'- CACCACAGGTTGAAAAAGCTTTG -3'
(R):5'- GATCGTTATGTGGCCATCTGTAACC -3'
Posted On2015-04-30