Incidental Mutation 'R0386:Or5m11'
ID 31275
Institutional Source Beutler Lab
Gene Symbol Or5m11
Ensembl Gene ENSMUSG00000057207
Gene Name olfactory receptor family 5 subfamily M member 11
Synonyms Olfr1028, GA_x6K02T2Q125-47430129-47431103, MOR198-3P, MOR198-4, MOR198-3P, MOR198-6_p, Olfr1534-ps1
MMRRC Submission 038592-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R0386 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85781409-85782383 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85782217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 270 (E270G)
Ref Sequence ENSEMBL: ENSMUSP00000079522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080698]
AlphaFold Q7TR89
Predicted Effect probably damaging
Transcript: ENSMUST00000080698
AA Change: E270G

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000079522
Gene: ENSMUSG00000057207
AA Change: E270G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.1e-55 PFAM
Pfam:7tm_1 41 290 1.5e-24 PFAM
Meta Mutation Damage Score 0.4821 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 90.3%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A G 5: 77,044,308 (GRCm39) V194A probably damaging Het
Adamts13 G A 2: 26,876,691 (GRCm39) probably null Het
Ahnak T C 19: 8,988,508 (GRCm39) M3264T possibly damaging Het
Birc6 T A 17: 74,906,335 (GRCm39) C1409S probably damaging Het
Camta1 C A 4: 151,159,597 (GRCm39) R1614L probably damaging Het
Dnah2 A G 11: 69,338,687 (GRCm39) V3161A probably damaging Het
Dnah5 A T 15: 28,383,727 (GRCm39) Y2983F probably damaging Het
Dnah6 G A 6: 73,060,107 (GRCm39) L2774F probably damaging Het
Dst A T 1: 34,256,917 (GRCm39) T4398S probably damaging Het
Efcab5 G A 11: 77,031,749 (GRCm39) R42W probably damaging Het
Efcab5 A T 11: 77,063,204 (GRCm39) M96K probably benign Het
Elavl4 A G 4: 110,063,902 (GRCm39) probably benign Het
Flt4 G A 11: 49,535,213 (GRCm39) A1214T probably benign Het
Fn1 G T 1: 71,634,945 (GRCm39) T2127N probably damaging Het
Foxj1 A T 11: 116,222,629 (GRCm39) S391R possibly damaging Het
Gabrb1 A T 5: 72,266,150 (GRCm39) Y269F probably damaging Het
Ghitm A G 14: 36,847,868 (GRCm39) S259P possibly damaging Het
Gm16332 A G 1: 139,851,928 (GRCm39) noncoding transcript Het
Gm16380 T A 9: 53,791,727 (GRCm39) noncoding transcript Het
Gm9869 A T 9: 60,745,344 (GRCm39) probably benign Het
Gm9936 G A 5: 114,995,192 (GRCm39) Q142* probably null Het
Hmbs T C 9: 44,248,305 (GRCm39) Y260C probably benign Het
Hoxc5 T A 15: 102,923,784 (GRCm39) C193* probably null Het
Idh2 C T 7: 79,748,005 (GRCm39) A232T probably damaging Het
Lce1j T C 3: 92,696,695 (GRCm39) K28E unknown Het
Lpgat1 C T 1: 191,451,460 (GRCm39) probably benign Het
Lyst T C 13: 13,882,799 (GRCm39) probably benign Het
Megf11 A G 9: 64,547,360 (GRCm39) N235D probably damaging Het
Mst1r T A 9: 107,794,003 (GRCm39) probably null Het
Nr2c2ap A G 8: 70,584,237 (GRCm39) D9G probably benign Het
Obscn T C 11: 59,027,165 (GRCm39) T13A probably damaging Het
Ofcc1 A C 13: 40,367,950 (GRCm39) L188* probably null Het
Oma1 A T 4: 103,182,398 (GRCm39) probably benign Het
Or10aa3 A T 1: 173,877,965 (GRCm39) T9S probably benign Het
Pcm1 T C 8: 41,769,060 (GRCm39) F1642S probably damaging Het
Pglyrp2 A G 17: 32,639,836 (GRCm39) M1T probably null Het
Pnpla5 G T 15: 84,004,920 (GRCm39) L144M probably damaging Het
Prdm10 C A 9: 31,227,596 (GRCm39) T67K probably damaging Het
Ralgapa1 A T 12: 55,754,852 (GRCm39) H1193Q probably benign Het
Sall1 A G 8: 89,759,232 (GRCm39) S291P probably damaging Het
Sdk2 T C 11: 113,784,290 (GRCm39) T150A probably damaging Het
Sel1l2 T A 2: 140,117,361 (GRCm39) Y170F probably benign Het
Sema4a C T 3: 88,344,107 (GRCm39) V715I possibly damaging Het
Smgc G A 15: 91,738,841 (GRCm39) A500T probably benign Het
Spef2 A G 15: 9,584,148 (GRCm39) V1639A probably damaging Het
Srrm4 A G 5: 116,620,437 (GRCm39) probably benign Het
Tbc1d23 G A 16: 57,009,636 (GRCm39) H418Y probably damaging Het
Tbk1 A G 10: 121,420,159 (GRCm39) L10P probably damaging Het
Thumpd3 G A 6: 113,042,621 (GRCm39) probably null Het
Trp53bp1 G T 2: 121,035,424 (GRCm39) T1609K probably damaging Het
Tut1 A G 19: 8,932,919 (GRCm39) N84S probably benign Het
Urb1 C T 16: 90,593,287 (GRCm39) G282R probably damaging Het
Usp19 A T 9: 108,376,910 (GRCm39) D1160V probably damaging Het
Usp9y A G Y: 1,316,933 (GRCm39) V1872A probably damaging Het
Zfp276 C A 8: 123,986,242 (GRCm39) Y386* probably null Het
Other mutations in Or5m11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02155:Or5m11 APN 2 85,782,352 (GRCm39) missense probably benign
R0483:Or5m11 UTSW 2 85,781,587 (GRCm39) missense probably damaging 0.98
R0539:Or5m11 UTSW 2 85,782,353 (GRCm39) missense probably benign
R5701:Or5m11 UTSW 2 85,782,168 (GRCm39) missense possibly damaging 0.87
R6459:Or5m11 UTSW 2 85,781,862 (GRCm39) missense probably damaging 1.00
R7124:Or5m11 UTSW 2 85,781,817 (GRCm39) missense possibly damaging 0.57
R7631:Or5m11 UTSW 2 85,782,218 (GRCm39) missense probably benign 0.06
R7943:Or5m11 UTSW 2 85,782,342 (GRCm39) missense probably benign 0.01
R8025:Or5m11 UTSW 2 85,781,856 (GRCm39) missense probably benign
R9221:Or5m11 UTSW 2 85,782,185 (GRCm39) nonsense probably null
R9312:Or5m11 UTSW 2 85,781,509 (GRCm39) missense possibly damaging 0.90
Z1177:Or5m11 UTSW 2 85,781,826 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- CCATATGCAACCCTCTGCGTTACAG -3'
(R):5'- TGGAAGGTGGACGCATCAATGCTG -3'

Sequencing Primer
(F):5'- GCTTCTCAGATGGACTATTCCAAG -3'
(R):5'- GCATCAATGCTGTCCTGATGAC -3'
Posted On 2013-04-24