Mutagenetix > Incidental Mutation

Incidental Mutation 'R0386:Dnah6'

31285

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

038592-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R0386 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

72994589-73198634 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 73060107 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 2774 (L2774F)

Ref Sequence

ENSEMBL: ENSMUSP00000109674 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000064948
AA Change: L2826F

PolyPhen 2 Score 0.787 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: L2826F

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000114038

SMART Domains

Protein: ENSMUSP00000109672
Gene: ENSMUSG00000052861

Domain	Start	End	E-Value	Type
Pfam:AAA_6	1	109	6.9e-45	PFAM
AAA	190	331	5.25e-1	SMART
low complexity region	407	417	N/A	INTRINSIC
AAA	533	686	1.01e-3	SMART
AAA	884	1042	3.08e0	SMART
low complexity region	1057	1068	N/A	INTRINSIC
low complexity region	1095	1106	N/A	INTRINSIC
Pfam:MT	1135	1267	1.1e-17	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000114040
AA Change: L2774F

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: L2774F

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000204053
AA Change: L2826F

PolyPhen 2 Score 0.787 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: L2826F

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Meta Mutation Damage Score

0.0931

Coding Region Coverage

1x: 99.1%
3x: 98.1%
10x: 95.5%
20x: 90.3%

Validation Efficiency

98% (56/57)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	A	G	5: 77,044,308 (GRCm39)	V194A	probably damaging	Het
Adamts13	G	A	2: 26,876,691 (GRCm39)		probably null	Het
Ahnak	T	C	19: 8,988,508 (GRCm39)	M3264T	possibly damaging	Het
Birc6	T	A	17: 74,906,335 (GRCm39)	C1409S	probably damaging	Het
Camta1	C	A	4: 151,159,597 (GRCm39)	R1614L	probably damaging	Het
Dnah2	A	G	11: 69,338,687 (GRCm39)	V3161A	probably damaging	Het
Dnah5	A	T	15: 28,383,727 (GRCm39)	Y2983F	probably damaging	Het
Dst	A	T	1: 34,256,917 (GRCm39)	T4398S	probably damaging	Het
Efcab5	G	A	11: 77,031,749 (GRCm39)	R42W	probably damaging	Het
Efcab5	A	T	11: 77,063,204 (GRCm39)	M96K	probably benign	Het
Elavl4	A	G	4: 110,063,902 (GRCm39)		probably benign	Het
Flt4	G	A	11: 49,535,213 (GRCm39)	A1214T	probably benign	Het
Fn1	G	T	1: 71,634,945 (GRCm39)	T2127N	probably damaging	Het
Foxj1	A	T	11: 116,222,629 (GRCm39)	S391R	possibly damaging	Het
Gabrb1	A	T	5: 72,266,150 (GRCm39)	Y269F	probably damaging	Het
Ghitm	A	G	14: 36,847,868 (GRCm39)	S259P	possibly damaging	Het
Gm16332	A	G	1: 139,851,928 (GRCm39)		noncoding transcript	Het
Gm16380	T	A	9: 53,791,727 (GRCm39)		noncoding transcript	Het
Gm9869	A	T	9: 60,745,344 (GRCm39)		probably benign	Het
Gm9936	G	A	5: 114,995,192 (GRCm39)	Q142*	probably null	Het
Hmbs	T	C	9: 44,248,305 (GRCm39)	Y260C	probably benign	Het
Hoxc5	T	A	15: 102,923,784 (GRCm39)	C193*	probably null	Het
Idh2	C	T	7: 79,748,005 (GRCm39)	A232T	probably damaging	Het
Lce1j	T	C	3: 92,696,695 (GRCm39)	K28E	unknown	Het
Lpgat1	C	T	1: 191,451,460 (GRCm39)		probably benign	Het
Lyst	T	C	13: 13,882,799 (GRCm39)		probably benign	Het
Megf11	A	G	9: 64,547,360 (GRCm39)	N235D	probably damaging	Het
Mst1r	T	A	9: 107,794,003 (GRCm39)		probably null	Het
Nr2c2ap	A	G	8: 70,584,237 (GRCm39)	D9G	probably benign	Het
Obscn	T	C	11: 59,027,165 (GRCm39)	T13A	probably damaging	Het
Ofcc1	A	C	13: 40,367,950 (GRCm39)	L188*	probably null	Het
Oma1	A	T	4: 103,182,398 (GRCm39)		probably benign	Het
Or10aa3	A	T	1: 173,877,965 (GRCm39)	T9S	probably benign	Het
Or5m11	A	G	2: 85,782,217 (GRCm39)	E270G	probably damaging	Het
Pcm1	T	C	8: 41,769,060 (GRCm39)	F1642S	probably damaging	Het
Pglyrp2	A	G	17: 32,639,836 (GRCm39)	M1T	probably null	Het
Pnpla5	G	T	15: 84,004,920 (GRCm39)	L144M	probably damaging	Het
Prdm10	C	A	9: 31,227,596 (GRCm39)	T67K	probably damaging	Het
Ralgapa1	A	T	12: 55,754,852 (GRCm39)	H1193Q	probably benign	Het
Sall1	A	G	8: 89,759,232 (GRCm39)	S291P	probably damaging	Het
Sdk2	T	C	11: 113,784,290 (GRCm39)	T150A	probably damaging	Het
Sel1l2	T	A	2: 140,117,361 (GRCm39)	Y170F	probably benign	Het
Sema4a	C	T	3: 88,344,107 (GRCm39)	V715I	possibly damaging	Het
Smgc	G	A	15: 91,738,841 (GRCm39)	A500T	probably benign	Het
Spef2	A	G	15: 9,584,148 (GRCm39)	V1639A	probably damaging	Het
Srrm4	A	G	5: 116,620,437 (GRCm39)		probably benign	Het
Tbc1d23	G	A	16: 57,009,636 (GRCm39)	H418Y	probably damaging	Het
Tbk1	A	G	10: 121,420,159 (GRCm39)	L10P	probably damaging	Het
Thumpd3	G	A	6: 113,042,621 (GRCm39)		probably null	Het
Trp53bp1	G	T	2: 121,035,424 (GRCm39)	T1609K	probably damaging	Het
Tut1	A	G	19: 8,932,919 (GRCm39)	N84S	probably benign	Het
Urb1	C	T	16: 90,593,287 (GRCm39)	G282R	probably damaging	Het
Usp19	A	T	9: 108,376,910 (GRCm39)	D1160V	probably damaging	Het
Usp9y	A	G	Y: 1,316,933 (GRCm39)	V1872A	probably damaging	Het
Zfp276	C	A	8: 123,986,242 (GRCm39)	Y386*	probably null	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,172,720 (GRCm39)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,063,190 (GRCm39)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,172,744 (GRCm39)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,189,417 (GRCm39)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,100,754 (GRCm39)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,133,333 (GRCm39)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,010,509 (GRCm39)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,060,140 (GRCm39)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,150,373 (GRCm39)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,051,764 (GRCm39)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,042,708 (GRCm39)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,150,439 (GRCm39)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,069,161 (GRCm39)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,051,731 (GRCm39)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,001,235 (GRCm39)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,052,785 (GRCm39)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,053,643 (GRCm39)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,165,360 (GRCm39)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,042,759 (GRCm39)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,112,784 (GRCm39)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,009,552 (GRCm39)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,037,126 (GRCm39)	missense	probably benign
IGL02126:Dnah6	APN	6	73,080,149 (GRCm39)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	72,994,780 (GRCm39)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,110,633 (GRCm39)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,145,894 (GRCm39)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,078,881 (GRCm39)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,053,623 (GRCm39)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,004,431 (GRCm39)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	72,998,210 (GRCm39)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,072,087 (GRCm39)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,098,806 (GRCm39)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,185,582 (GRCm39)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,115,698 (GRCm39)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,009,570 (GRCm39)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,126,123 (GRCm39)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,121,987 (GRCm39)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,018,037 (GRCm39)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,121,683 (GRCm39)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,030,630 (GRCm39)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,060,068 (GRCm39)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,052,833 (GRCm39)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,140,487 (GRCm39)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,042,738 (GRCm39)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,185,624 (GRCm39)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,078,863 (GRCm39)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,091,565 (GRCm39)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,037,243 (GRCm39)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,015,717 (GRCm39)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,165,518 (GRCm39)	splice site	probably benign
R0165:Dnah6	UTSW	6	72,998,306 (GRCm39)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,059,906 (GRCm39)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,136,098 (GRCm39)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,150,541 (GRCm39)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,046,382 (GRCm39)	splice site	probably benign
R0345:Dnah6	UTSW	6	72,998,240 (GRCm39)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,165,342 (GRCm39)	missense	probably benign
R0362:Dnah6	UTSW	6	73,185,592 (GRCm39)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R0547:Dnah6	UTSW	6	73,021,757 (GRCm39)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	72,999,395 (GRCm39)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,100,794 (GRCm39)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,106,457 (GRCm39)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,189,605 (GRCm39)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,064,585 (GRCm39)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,012,276 (GRCm39)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,101,740 (GRCm39)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,136,176 (GRCm39)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,121,948 (GRCm39)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,136,118 (GRCm39)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,101,692 (GRCm39)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,185,528 (GRCm39)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,168,602 (GRCm39)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,004,425 (GRCm39)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,026,031 (GRCm39)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,128,536 (GRCm39)	missense	probably benign
R1557:Dnah6	UTSW	6	73,026,114 (GRCm39)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,053,583 (GRCm39)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,044,452 (GRCm39)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,121,946 (GRCm39)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,077,095 (GRCm39)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,021,735 (GRCm39)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,132,279 (GRCm39)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,182,715 (GRCm39)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,106,523 (GRCm39)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,021,744 (GRCm39)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,137,965 (GRCm39)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,001,941 (GRCm39)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,158,780 (GRCm39)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,077,071 (GRCm39)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,158,745 (GRCm39)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,061,704 (GRCm39)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,098,953 (GRCm39)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,072,027 (GRCm39)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,069,175 (GRCm39)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,044,449 (GRCm39)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,150,402 (GRCm39)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,004,405 (GRCm39)	missense	probably benign
R2041:Dnah6	UTSW	6	73,050,422 (GRCm39)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	72,998,165 (GRCm39)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,121,018 (GRCm39)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,026,149 (GRCm39)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,066,729 (GRCm39)	splice site	probably null
R2193:Dnah6	UTSW	6	73,115,623 (GRCm39)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,077,068 (GRCm39)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,090,564 (GRCm39)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	72,998,092 (GRCm39)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,133,404 (GRCm39)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,068,950 (GRCm39)	splice site	probably null
R2436:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,150,333 (GRCm39)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,009,616 (GRCm39)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,168,481 (GRCm39)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,104,910 (GRCm39)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,066,575 (GRCm39)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,106,431 (GRCm39)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,126,467 (GRCm39)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,095,009 (GRCm39)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,106,274 (GRCm39)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,168,462 (GRCm39)	missense	probably benign
R4486:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,155,399 (GRCm39)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,169,388 (GRCm39)	missense	probably benign
R4573:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,129,695 (GRCm39)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,106,643 (GRCm39)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,047,580 (GRCm39)	missense	probably benign
R4653:Dnah6	UTSW	6	73,050,440 (GRCm39)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,014,671 (GRCm39)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,169,405 (GRCm39)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,001,995 (GRCm39)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,106,513 (GRCm39)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,072,057 (GRCm39)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,066,651 (GRCm39)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	72,999,407 (GRCm39)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,021,745 (GRCm39)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,098,771 (GRCm39)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,169,659 (GRCm39)	intron	probably benign
R4948:Dnah6	UTSW	6	73,030,672 (GRCm39)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,165,366 (GRCm39)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,121,798 (GRCm39)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,021,674 (GRCm39)	missense	probably benign
R5044:Dnah6	UTSW	6	73,014,605 (GRCm39)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,158,744 (GRCm39)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,172,617 (GRCm39)	missense	probably benign
R5186:Dnah6	UTSW	6	73,044,410 (GRCm39)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,172,715 (GRCm39)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,090,471 (GRCm39)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,104,844 (GRCm39)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,189,603 (GRCm39)	missense	probably benign
R5343:Dnah6	UTSW	6	73,189,599 (GRCm39)	missense	probably benign
R5375:Dnah6	UTSW	6	73,100,838 (GRCm39)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,014,598 (GRCm39)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,037,121 (GRCm39)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,052,717 (GRCm39)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,063,168 (GRCm39)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,069,140 (GRCm39)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,069,099 (GRCm39)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,167,402 (GRCm39)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,136,212 (GRCm39)	missense	probably benign
R5541:Dnah6	UTSW	6	73,169,971 (GRCm39)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,128,672 (GRCm39)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,126,508 (GRCm39)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	72,998,210 (GRCm39)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,037,262 (GRCm39)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,158,705 (GRCm39)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,063,149 (GRCm39)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,091,680 (GRCm39)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,165,477 (GRCm39)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,063,200 (GRCm39)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,168,588 (GRCm39)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,132,401 (GRCm39)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,051,569 (GRCm39)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,051,687 (GRCm39)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,021,715 (GRCm39)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,150,516 (GRCm39)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,030,678 (GRCm39)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,012,263 (GRCm39)	splice site	probably null
R6640:Dnah6	UTSW	6	73,001,276 (GRCm39)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,115,743 (GRCm39)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,014,532 (GRCm39)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,110,591 (GRCm39)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,110,525 (GRCm39)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,189,505 (GRCm39)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,158,738 (GRCm39)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,021,756 (GRCm39)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	72,998,161 (GRCm39)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,064,545 (GRCm39)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,112,663 (GRCm39)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,158,688 (GRCm39)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,150,528 (GRCm39)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,061,743 (GRCm39)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,121,705 (GRCm39)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,189,595 (GRCm39)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,169,300 (GRCm39)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,189,475 (GRCm39)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,104,887 (GRCm39)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,095,082 (GRCm39)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,004,423 (GRCm39)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,126,413 (GRCm39)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,069,151 (GRCm39)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,072,189 (GRCm39)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,101,742 (GRCm39)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,146,063 (GRCm39)	splice site	probably null
R7735:Dnah6	UTSW	6	73,046,412 (GRCm39)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,002,703 (GRCm39)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,104,902 (GRCm39)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,112,450 (GRCm39)	splice site	probably null
R8034:Dnah6	UTSW	6	73,106,208 (GRCm39)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,137,896 (GRCm39)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,002,769 (GRCm39)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,037,208 (GRCm39)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,014,549 (GRCm39)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,021,711 (GRCm39)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,145,810 (GRCm39)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,172,664 (GRCm39)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,053,582 (GRCm39)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,001,983 (GRCm39)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,051,634 (GRCm39)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,115,757 (GRCm39)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,155,440 (GRCm39)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,072,171 (GRCm39)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,145,850 (GRCm39)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,052,873 (GRCm39)	intron	probably benign
R8737:Dnah6	UTSW	6	73,044,428 (GRCm39)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,156,811 (GRCm39)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,042,756 (GRCm39)	missense	probably benign
R8809:Dnah6	UTSW	6	73,009,546 (GRCm39)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,104,937 (GRCm39)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,121,156 (GRCm39)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	72,998,131 (GRCm39)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,155,481 (GRCm39)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,121,734 (GRCm39)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,119,275 (GRCm39)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,061,640 (GRCm39)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,121,029 (GRCm39)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,044,469 (GRCm39)	missense	probably benign
R9106:Dnah6	UTSW	6	73,121,752 (GRCm39)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,037,186 (GRCm39)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,098,882 (GRCm39)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,121,924 (GRCm39)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,121,688 (GRCm39)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,004,497 (GRCm39)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,060,040 (GRCm39)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	72,998,261 (GRCm39)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,189,513 (GRCm39)	missense	probably benign
R9439:Dnah6	UTSW	6	73,012,330 (GRCm39)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,119,299 (GRCm39)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,115,750 (GRCm39)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,168,589 (GRCm39)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,078,872 (GRCm39)	missense	probably benign
RF020:Dnah6	UTSW	6	73,095,040 (GRCm39)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,155,501 (GRCm39)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,168,483 (GRCm39)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,014,656 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,110,542 (GRCm39)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,064,766 (GRCm39)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,009,509 (GRCm39)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	72,998,220 (GRCm39)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,132,255 (GRCm39)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,018,121 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTGACCACCCGAGAGTACAGATCC -3'
(R):5'- CTTTCCTAGCCAGGCAGTTGTAGTG -3'

Sequencing Primer
(F):5'- AGGCACGAAGTCAGGATTGT -3'
(R):5'- gtcagtcctacacagagaaacc -3'

Posted On

2013-04-24