Incidental Mutation 'R4028:Oog4'
| ID |
313082 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Oog4
|
| Ensembl Gene |
ENSMUSG00000047799 |
| Gene Name |
oogenesin 4 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.095)
|
| Stock # |
R4028 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
143163734-143176894 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 143166770 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 11
(N11K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073325
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061277]
[ENSMUST00000073641]
|
| AlphaFold |
Q4G0C7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061277
|
| SMART Domains |
Protein: ENSMUSP00000052217
Gene: ENSMUSG00000047799
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1a4ya_
|
195 |
357 |
6e-7 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073641
AA Change: N11K
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000073325
Gene: ENSMUSG00000047799
AA Change: N11K
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1a4ya_
|
267 |
429 |
3e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam12 |
A |
T |
7: 133,531,725 (GRCm39) |
N503K |
probably damaging |
Het |
| Anapc2 |
T |
A |
2: 25,167,750 (GRCm39) |
I439N |
probably damaging |
Het |
| Ank |
A |
G |
15: 27,544,343 (GRCm39) |
N35D |
probably damaging |
Het |
| Birc2 |
T |
C |
9: 7,819,352 (GRCm39) |
N520S |
probably benign |
Het |
| C030005K15Rik |
T |
C |
10: 97,561,404 (GRCm39) |
Y109C |
unknown |
Het |
| Chrna5 |
T |
C |
9: 54,905,370 (GRCm39) |
W61R |
probably damaging |
Het |
| Clec1b |
G |
A |
6: 129,378,774 (GRCm39) |
R87H |
probably benign |
Het |
| Cox7a2l |
A |
G |
17: 83,810,069 (GRCm39) |
I123T |
probably benign |
Het |
| Cyp2j5 |
A |
T |
4: 96,529,653 (GRCm39) |
Y239* |
probably null |
Het |
| Dnajc6 |
G |
A |
4: 101,474,054 (GRCm39) |
C485Y |
probably damaging |
Het |
| Dync1i1 |
C |
T |
6: 5,961,842 (GRCm39) |
S341F |
probably damaging |
Het |
| Fbln1 |
A |
G |
15: 85,111,317 (GRCm39) |
N157S |
probably benign |
Het |
| Get1 |
T |
C |
16: 95,946,784 (GRCm39) |
|
probably null |
Het |
| Gpatch2 |
A |
G |
1: 186,958,337 (GRCm39) |
S231G |
possibly damaging |
Het |
| Grin2b |
T |
C |
6: 135,713,433 (GRCm39) |
D816G |
probably damaging |
Het |
| Kndc1 |
T |
A |
7: 139,509,941 (GRCm39) |
F1261Y |
probably damaging |
Het |
| Lefty1 |
T |
C |
1: 180,765,346 (GRCm39) |
S305P |
probably benign |
Het |
| Ltbp3 |
G |
A |
19: 5,804,050 (GRCm39) |
R854Q |
probably benign |
Het |
| Mrc1 |
T |
C |
2: 14,243,059 (GRCm39) |
S62P |
probably damaging |
Het |
| Ntrk3 |
T |
C |
7: 77,842,458 (GRCm39) |
E790G |
probably damaging |
Het |
| Obscn |
T |
C |
11: 59,022,472 (GRCm39) |
R758G |
possibly damaging |
Het |
| Or4c3 |
T |
C |
2: 89,851,567 (GRCm39) |
N281S |
probably damaging |
Het |
| Or52k2 |
A |
T |
7: 102,254,500 (GRCm39) |
D313V |
possibly damaging |
Het |
| Pibf1 |
A |
G |
14: 99,416,777 (GRCm39) |
E450G |
probably damaging |
Het |
| Pkd1l3 |
T |
A |
8: 110,350,603 (GRCm39) |
S483T |
possibly damaging |
Het |
| Pkdrej |
A |
T |
15: 85,701,693 (GRCm39) |
N1414K |
probably benign |
Het |
| Pld2 |
A |
G |
11: 70,445,731 (GRCm39) |
N655S |
probably damaging |
Het |
| Pramel28 |
T |
A |
4: 143,692,354 (GRCm39) |
T216S |
probably benign |
Het |
| Rcn1 |
G |
T |
2: 105,229,395 (GRCm39) |
Y52* |
probably null |
Het |
| Reck |
T |
C |
4: 43,922,931 (GRCm39) |
I402T |
probably damaging |
Het |
| Shisal2a |
G |
T |
4: 108,240,412 (GRCm39) |
C43* |
probably null |
Het |
| Slc28a3 |
T |
C |
13: 58,758,570 (GRCm39) |
S18G |
probably benign |
Het |
| Slc7a1 |
C |
A |
5: 148,282,622 (GRCm39) |
C75F |
probably benign |
Het |
| Snrnp200 |
A |
G |
2: 127,079,486 (GRCm39) |
D1865G |
probably damaging |
Het |
| Tnrc6a |
T |
A |
7: 122,769,344 (GRCm39) |
I378N |
probably damaging |
Het |
| Trim3 |
A |
G |
7: 105,267,452 (GRCm39) |
V309A |
probably benign |
Het |
| Tshz1 |
T |
C |
18: 84,032,954 (GRCm39) |
K485E |
possibly damaging |
Het |
| Zdhhc11 |
T |
C |
13: 74,125,390 (GRCm39) |
L210P |
probably damaging |
Het |
|
| Other mutations in Oog4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01580:Oog4
|
APN |
4 |
143,165,682 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02207:Oog4
|
APN |
4 |
143,165,510 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0038:Oog4
|
UTSW |
4 |
143,165,514 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0038:Oog4
|
UTSW |
4 |
143,165,514 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0326:Oog4
|
UTSW |
4 |
143,165,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0372:Oog4
|
UTSW |
4 |
143,164,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1056:Oog4
|
UTSW |
4 |
143,164,581 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1598:Oog4
|
UTSW |
4 |
143,164,571 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1712:Oog4
|
UTSW |
4 |
143,166,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4029:Oog4
|
UTSW |
4 |
143,166,770 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4030:Oog4
|
UTSW |
4 |
143,166,770 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4705:Oog4
|
UTSW |
4 |
143,165,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5260:Oog4
|
UTSW |
4 |
143,164,424 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5945:Oog4
|
UTSW |
4 |
143,164,293 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6499:Oog4
|
UTSW |
4 |
143,164,548 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6614:Oog4
|
UTSW |
4 |
143,164,445 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6852:Oog4
|
UTSW |
4 |
143,165,679 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7371:Oog4
|
UTSW |
4 |
143,165,346 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7375:Oog4
|
UTSW |
4 |
143,165,544 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7501:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7564:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7678:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7688:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R7689:Oog4
|
UTSW |
4 |
143,164,022 (GRCm39) |
frame shift |
probably null |
|
|
R8219:Oog4
|
UTSW |
4 |
143,166,508 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8274:Oog4
|
UTSW |
4 |
143,166,459 (GRCm39) |
splice site |
probably benign |
|
|
R8352:Oog4
|
UTSW |
4 |
143,164,047 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8452:Oog4
|
UTSW |
4 |
143,164,047 (GRCm39) |
missense |
probably benign |
0.22 |
|
Z1177:Oog4
|
UTSW |
4 |
143,164,145 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Oog4
|
UTSW |
4 |
143,164,144 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- TATACGTCCACCAATTACGGC -3'
(R):5'- GGCTTTAAAACCAACAAAGGCTG -3'
Sequencing Primer
(F):5'- CGGCTGCTTCAAAAATTGCTG -3'
(R):5'- CAAGCAGGCATCTCTTTGAGGTC -3'
|
| Posted On |
2015-04-30 |
Incidental Mutation