Incidental Mutation 'R4023:Vmn1r34'
| ID |
313343 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r34
|
| Ensembl Gene |
ENSMUSG00000091012 |
| Gene Name |
vomeronasal 1 receptor 34 |
| Synonyms |
Gm5991 |
| MMRRC Submission |
040957-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
R4023 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
66613807-66614736 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 66614688 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 17
(M17L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153720
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074381]
[ENSMUST00000226262]
[ENSMUST00000226910]
[ENSMUST00000226999]
[ENSMUST00000227332]
[ENSMUST00000228498]
[ENSMUST00000228647]
|
| AlphaFold |
G3XA52 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000074381
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000132900
Gene: ENSMUSG00000091012
AA Change: M17L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
2.2e-54 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226262
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226910
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226999
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227332
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228498
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228647
AA Change: M17L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
CGGG |
CGGGGGG |
15: 76,833,863 (GRCm39) |
|
probably benign |
Het |
| Acad8 |
T |
C |
9: 26,890,481 (GRCm39) |
I276V |
probably benign |
Het |
| Adgrg7 |
A |
T |
16: 56,550,661 (GRCm39) |
Y684N |
probably damaging |
Het |
| Akap9 |
C |
T |
5: 4,042,077 (GRCm39) |
T1370I |
possibly damaging |
Het |
| Akna |
C |
G |
4: 63,292,627 (GRCm39) |
G1094A |
probably benign |
Het |
| Catsperb |
C |
A |
12: 101,568,942 (GRCm39) |
Y871* |
probably null |
Het |
| Clcn4 |
T |
G |
7: 7,293,427 (GRCm39) |
Y443S |
probably damaging |
Het |
| Clcn6 |
T |
A |
4: 148,098,740 (GRCm39) |
T463S |
possibly damaging |
Het |
| Colec10 |
A |
G |
15: 54,325,947 (GRCm39) |
D259G |
probably damaging |
Het |
| Ctnna2 |
A |
T |
6: 77,613,827 (GRCm39) |
D254E |
possibly damaging |
Het |
| Depdc1a |
G |
A |
3: 159,221,786 (GRCm39) |
|
probably null |
Het |
| Dlec1 |
T |
C |
9: 118,966,408 (GRCm39) |
Y1126H |
probably damaging |
Het |
| Fezf2 |
A |
T |
14: 12,343,986 (GRCm38) |
C302S |
probably damaging |
Het |
| Flnc |
T |
C |
6: 29,451,634 (GRCm39) |
I1591T |
possibly damaging |
Het |
| Kidins220 |
A |
G |
12: 25,107,143 (GRCm39) |
|
probably null |
Het |
| Mctp2 |
C |
A |
7: 71,739,987 (GRCm39) |
C801F |
possibly damaging |
Het |
| Myo1e |
A |
G |
9: 70,232,157 (GRCm39) |
I229V |
probably benign |
Het |
| Or5t17 |
A |
T |
2: 86,833,266 (GRCm39) |
K318* |
probably null |
Het |
| Or8c17 |
G |
A |
9: 38,180,757 (GRCm39) |
C308Y |
possibly damaging |
Het |
| Ppp3r1 |
T |
C |
11: 17,144,786 (GRCm39) |
V133A |
probably damaging |
Het |
| Rif1 |
T |
A |
2: 52,011,099 (GRCm39) |
Y2389N |
probably benign |
Het |
| Sidt1 |
A |
G |
16: 44,102,249 (GRCm39) |
S304P |
possibly damaging |
Het |
| Siglecf |
T |
A |
7: 43,004,995 (GRCm39) |
S408R |
possibly damaging |
Het |
| Stat5a |
T |
A |
11: 100,765,752 (GRCm39) |
C279* |
probably null |
Het |
| Tas2r105 |
A |
G |
6: 131,663,789 (GRCm39) |
V213A |
probably benign |
Het |
| Tasor2 |
T |
C |
13: 3,634,554 (GRCm39) |
D751G |
probably damaging |
Het |
| Tektl1 |
T |
C |
10: 78,588,727 (GRCm39) |
T28A |
probably benign |
Het |
| Top2b |
T |
G |
14: 16,409,189 (GRCm38) |
I777M |
probably damaging |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Usp46 |
A |
G |
5: 74,193,136 (GRCm39) |
Y47H |
probably damaging |
Het |
| Vmn2r120 |
T |
A |
17: 57,843,718 (GRCm39) |
D42V |
possibly damaging |
Het |
| Wdr20 |
A |
G |
12: 110,759,950 (GRCm39) |
T279A |
probably benign |
Het |
| Zfyve1 |
A |
G |
12: 83,641,296 (GRCm39) |
V120A |
probably benign |
Het |
|
| Other mutations in Vmn1r34 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00974:Vmn1r34
|
APN |
6 |
66,614,639 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01322:Vmn1r34
|
APN |
6 |
66,613,899 (GRCm39) |
nonsense |
probably null |
|
|
IGL01866:Vmn1r34
|
APN |
6 |
66,614,373 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02389:Vmn1r34
|
APN |
6 |
66,614,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03356:Vmn1r34
|
APN |
6 |
66,613,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0508:Vmn1r34
|
UTSW |
6 |
66,614,392 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0601:Vmn1r34
|
UTSW |
6 |
66,614,648 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1381:Vmn1r34
|
UTSW |
6 |
66,613,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1605:Vmn1r34
|
UTSW |
6 |
66,613,932 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1765:Vmn1r34
|
UTSW |
6 |
66,614,480 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2022:Vmn1r34
|
UTSW |
6 |
66,614,385 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3878:Vmn1r34
|
UTSW |
6 |
66,614,552 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4024:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4025:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4026:Vmn1r34
|
UTSW |
6 |
66,614,688 (GRCm39) |
missense |
probably benign |
|
|
R4385:Vmn1r34
|
UTSW |
6 |
66,614,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5274:Vmn1r34
|
UTSW |
6 |
66,614,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Vmn1r34
|
UTSW |
6 |
66,614,312 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6629:Vmn1r34
|
UTSW |
6 |
66,614,499 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7143:Vmn1r34
|
UTSW |
6 |
66,614,648 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7689:Vmn1r34
|
UTSW |
6 |
66,613,994 (GRCm39) |
nonsense |
probably null |
|
|
R7956:Vmn1r34
|
UTSW |
6 |
66,614,777 (GRCm39) |
start gained |
probably benign |
|
|
R8031:Vmn1r34
|
UTSW |
6 |
66,614,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9570:Vmn1r34
|
UTSW |
6 |
66,614,718 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0066:Vmn1r34
|
UTSW |
6 |
66,614,459 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Vmn1r34
|
UTSW |
6 |
66,614,109 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTCATTGACAATGTTCAATGACCC -3'
(R):5'- GGCTCAGATGTAATACAGGCAC -3'
Sequencing Primer
(F):5'- TGACCCAAGTAAATCTGTAAGCC -3'
(R):5'- GCTAATCGATGCCTCAATGTAGG -3'
|
| Posted On |
2015-04-30 |
Incidental Mutation