Incidental Mutation 'R4031:Zfp975'
ID 313491
Institutional Source Beutler Lab
Gene Symbol Zfp975
Ensembl Gene ENSMUSG00000069727
Gene Name zinc finger protein 975
Synonyms Gm5595
MMRRC Submission 040960-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R4031 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 42309529-42342166 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 42312377 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 79 (Q79*)
Ref Sequence ENSEMBL: ENSMUSP00000103626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107992]
AlphaFold Q6NVD6
Predicted Effect probably null
Transcript: ENSMUST00000107992
AA Change: Q79*
SMART Domains Protein: ENSMUSP00000103626
Gene: ENSMUSG00000069727
AA Change: Q79*

DomainStartEndE-ValueType
KRAB 4 66 1.53e-19 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 9.73e-4 SMART
ZnF_C2H2 187 209 1.47e-3 SMART
ZnF_C2H2 215 237 3.89e-3 SMART
ZnF_C2H2 243 265 2.57e-3 SMART
ZnF_C2H2 271 293 7.26e-3 SMART
ZnF_C2H2 299 321 1.58e-3 SMART
ZnF_C2H2 327 349 7.9e-4 SMART
ZnF_C2H2 355 377 5.9e-3 SMART
ZnF_C2H2 383 405 1.58e-3 SMART
ZnF_C2H2 411 433 6.32e-3 SMART
ZnF_C2H2 439 461 8.47e-4 SMART
ZnF_C2H2 467 489 2.57e-3 SMART
ZnF_C2H2 495 517 3.16e-3 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 95% (52/55)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 G T 8: 87,244,077 (GRCm39) F1025L probably damaging Het
Acss2 C T 2: 155,399,130 (GRCm39) T477I probably damaging Het
Aplp2 G A 9: 31,069,026 (GRCm39) P601L probably benign Het
Arl2bp T C 8: 95,394,281 (GRCm39) I32T probably damaging Het
Avpi1 C A 19: 42,113,180 (GRCm39) probably benign Het
C030005K15Rik T C 10: 97,561,404 (GRCm39) Y109C unknown Het
Ccdc150 T A 1: 54,317,970 (GRCm39) M303K probably benign Het
Chrna5 T C 9: 54,905,370 (GRCm39) W61R probably damaging Het
Copa T C 1: 171,935,942 (GRCm39) V428A probably damaging Het
Crybb3 A G 5: 113,227,735 (GRCm39) Y29H probably damaging Het
Dcun1d4 A G 5: 73,691,980 (GRCm39) D89G probably damaging Het
Disp2 T C 2: 118,622,361 (GRCm39) I1031T probably benign Het
Elf1 A C 14: 79,806,723 (GRCm39) K161Q probably damaging Het
Fndc1 A T 17: 7,988,584 (GRCm39) Y1159* probably null Het
Hspa12a T C 19: 58,789,289 (GRCm39) N449S probably benign Het
Hyal4 A G 6: 24,756,223 (GRCm39) E147G probably damaging Het
Hydin T C 8: 111,336,679 (GRCm39) I5152T probably benign Het
Ighv9-1 C T 12: 114,057,844 (GRCm39) A19T probably benign Het
Kcnt1 T G 2: 25,806,060 (GRCm39) S1216R possibly damaging Het
Kdm5d T A Y: 916,910 (GRCm39) V435E probably damaging Het
Klhl30 G A 1: 91,288,879 (GRCm39) R546H probably benign Het
Lrp1b C T 2: 40,592,860 (GRCm39) G3753D probably benign Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Macf1 A G 4: 123,275,105 (GRCm39) L6303P probably damaging Het
Mblac2 T C 13: 81,898,208 (GRCm39) S195P possibly damaging Het
Mindy3 A C 2: 12,405,894 (GRCm39) probably null Het
Neurod1 C T 2: 79,284,370 (GRCm39) D338N probably benign Het
Polr1e A T 4: 45,018,685 (GRCm39) E5V probably benign Het
Polr2b G A 5: 77,496,252 (GRCm39) R1141H possibly damaging Het
Ppp2r2a T C 14: 67,266,425 (GRCm39) S79G probably damaging Het
Psmd2 G A 16: 20,481,955 (GRCm39) G896D probably damaging Het
Rap1gds1 T C 3: 138,756,353 (GRCm39) probably benign Het
Rsph10b A G 5: 143,922,486 (GRCm39) probably null Het
Slc26a10 A G 10: 127,013,871 (GRCm39) V297A possibly damaging Het
Slc26a5 T C 5: 22,052,189 (GRCm39) K47E probably damaging Het
Slurp1 T C 15: 74,599,336 (GRCm39) E58G probably damaging Het
Spo11 T A 2: 172,828,625 (GRCm39) probably benign Het
Tm9sf4 T C 2: 153,040,264 (GRCm39) probably benign Het
Trak1 T C 9: 121,280,736 (GRCm39) I272T probably damaging Het
Tshz1 T C 18: 84,032,954 (GRCm39) K485E possibly damaging Het
Ttn T A 2: 76,585,168 (GRCm39) I22042F probably damaging Het
Unc79 T A 12: 103,039,018 (GRCm39) S671T possibly damaging Het
Usp43 G T 11: 67,804,659 (GRCm39) A186D probably damaging Het
Vmn2r107 G A 17: 20,595,483 (GRCm39) V679I probably benign Het
Vsig10l C T 7: 43,114,798 (GRCm39) A333V probably damaging Het
Vwa3a G A 7: 120,367,455 (GRCm39) probably null Het
Wdr49 C A 3: 75,230,972 (GRCm39) L563F probably benign Het
Wnk1 T C 6: 119,928,029 (GRCm39) T1141A probably damaging Het
Zfp236 T A 18: 82,642,590 (GRCm39) E1052V probably damaging Het
Zfp317 A T 9: 19,558,008 (GRCm39) H163L possibly damaging Het
Other mutations in Zfp975
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Zfp975 APN 7 42,312,215 (GRCm39) missense probably damaging 1.00
R0194:Zfp975 UTSW 7 42,311,916 (GRCm39) missense probably benign 0.02
R0662:Zfp975 UTSW 7 42,311,950 (GRCm39) missense probably benign 0.02
R1491:Zfp975 UTSW 7 42,312,236 (GRCm39) missense probably benign 0.19
R1573:Zfp975 UTSW 7 42,311,507 (GRCm39) missense probably benign 0.03
R1738:Zfp975 UTSW 7 42,312,373 (GRCm39) missense probably benign 0.05
R1833:Zfp975 UTSW 7 42,311,263 (GRCm39) missense probably benign 0.01
R2185:Zfp975 UTSW 7 42,311,105 (GRCm39) missense possibly damaging 0.90
R4090:Zfp975 UTSW 7 42,312,298 (GRCm39) missense probably benign 0.10
R4356:Zfp975 UTSW 7 42,311,251 (GRCm39) missense probably damaging 1.00
R4631:Zfp975 UTSW 7 42,312,369 (GRCm39) missense probably benign 0.09
R4795:Zfp975 UTSW 7 42,314,570 (GRCm39) critical splice acceptor site probably null
R4896:Zfp975 UTSW 7 42,311,716 (GRCm39) missense probably damaging 1.00
R5266:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5267:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5580:Zfp975 UTSW 7 42,314,513 (GRCm39) nonsense probably null
R5874:Zfp975 UTSW 7 42,312,312 (GRCm39) missense probably benign 0.00
R5898:Zfp975 UTSW 7 42,311,963 (GRCm39) missense probably damaging 1.00
R6529:Zfp975 UTSW 7 42,311,325 (GRCm39) missense possibly damaging 0.79
R6782:Zfp975 UTSW 7 42,311,454 (GRCm39) missense probably benign 0.41
R6937:Zfp975 UTSW 7 42,314,480 (GRCm39) missense possibly damaging 0.61
R7088:Zfp975 UTSW 7 42,312,096 (GRCm39) missense probably benign 0.02
R7233:Zfp975 UTSW 7 42,311,918 (GRCm39) missense probably benign 0.38
R7253:Zfp975 UTSW 7 42,311,036 (GRCm39) makesense probably null
R7358:Zfp975 UTSW 7 42,312,215 (GRCm39) missense probably damaging 1.00
R7659:Zfp975 UTSW 7 42,311,848 (GRCm39) missense probably benign 0.00
R7999:Zfp975 UTSW 7 42,312,356 (GRCm39) missense probably benign 0.02
R8676:Zfp975 UTSW 7 42,312,264 (GRCm39) missense probably benign 0.44
R8957:Zfp975 UTSW 7 42,311,157 (GRCm39) missense probably damaging 1.00
R9274:Zfp975 UTSW 7 42,312,299 (GRCm39) missense probably benign 0.02
R9326:Zfp975 UTSW 7 42,311,837 (GRCm39) nonsense probably null
R9536:Zfp975 UTSW 7 42,312,345 (GRCm39) missense probably benign 0.11
R9569:Zfp975 UTSW 7 42,311,413 (GRCm39) missense probably benign 0.00
R9717:Zfp975 UTSW 7 42,312,332 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- AGGGTCTCACTCCAGTATGTAC -3'
(R):5'- AGGCCATCTCTCTAGTCCCT -3'

Sequencing Primer
(F):5'- TGACTCCTTAGTGCAAAGGC -3'
(R):5'- TCTAGTCCCTTGATAAAACCCTAAG -3'
Posted On 2015-04-30