Incidental Mutation 'R4035:Ifi203'
ID 313648
Institutional Source Beutler Lab
Gene Symbol Ifi203
Ensembl Gene ENSMUSG00000039997
Gene Name interferon activated gene 203
Synonyms
MMRRC Submission 041613-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R4035 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 173747973-173770238 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 173757040 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114221 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042228] [ENSMUST00000081216] [ENSMUST00000111210] [ENSMUST00000123708] [ENSMUST00000129829] [ENSMUST00000156895]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000042228
SMART Domains Protein: ENSMUSP00000042071
Gene: ENSMUSG00000039997

DomainStartEndE-ValueType
PYRIN 6 84 1.01e-21 SMART
low complexity region 133 150 N/A INTRINSIC
low complexity region 170 188 N/A INTRINSIC
Pfam:HIN 251 418 1.5e-77 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000081216
SMART Domains Protein: ENSMUSP00000079976
Gene: ENSMUSG00000039997

DomainStartEndE-ValueType
PYRIN 6 84 1.01e-21 SMART
low complexity region 133 150 N/A INTRINSIC
low complexity region 174 183 N/A INTRINSIC
Pfam:HIN 203 370 1.3e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111210
SMART Domains Protein: ENSMUSP00000106841
Gene: ENSMUSG00000090272

DomainStartEndE-ValueType
PYRIN 5 83 3.71e-20 SMART
internal_repeat_1 152 166 2.38e-7 PROSPERO
low complexity region 170 200 N/A INTRINSIC
internal_repeat_1 208 222 2.38e-7 PROSPERO
low complexity region 225 249 N/A INTRINSIC
low complexity region 276 292 N/A INTRINSIC
low complexity region 294 305 N/A INTRINSIC
Pfam:HIN 311 479 3.4e-76 PFAM
low complexity region 497 507 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000123708
SMART Domains Protein: ENSMUSP00000121480
Gene: ENSMUSG00000039997

DomainStartEndE-ValueType
PYRIN 6 84 1.01e-21 SMART
low complexity region 133 150 N/A INTRINSIC
low complexity region 174 183 N/A INTRINSIC
Pfam:HIN 203 370 1.3e-76 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128430
Predicted Effect unknown
Transcript: ENSMUST00000129829
AA Change: T248S
SMART Domains Protein: ENSMUSP00000122424
Gene: ENSMUSG00000039997
AA Change: T248S

DomainStartEndE-ValueType
PYRIN 6 84 1.01e-21 SMART
low complexity region 133 150 N/A INTRINSIC
low complexity region 170 188 N/A INTRINSIC
low complexity region 607 623 N/A INTRINSIC
Pfam:HIN 665 831 7.2e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135331
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138143
Predicted Effect probably benign
Transcript: ENSMUST00000156895
SMART Domains Protein: ENSMUSP00000114221
Gene: ENSMUSG00000039997

DomainStartEndE-ValueType
PYRIN 6 84 1.01e-21 SMART
low complexity region 133 150 N/A INTRINSIC
low complexity region 170 188 N/A INTRINSIC
Pfam:HIN 251 418 1.5e-77 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013D24Rik A G 6: 124,333,879 (GRCm39) F34L probably benign Het
Abcb8 A G 5: 24,605,619 (GRCm39) S168G probably benign Het
Ano5 A G 7: 51,216,233 (GRCm39) probably benign Het
Api5 C T 2: 94,255,958 (GRCm39) R243Q possibly damaging Het
Bhlhe41 A G 6: 145,808,754 (GRCm39) S353P probably benign Het
Ccdc88c G A 12: 100,896,783 (GRCm39) A1389V possibly damaging Het
Cep350 T C 1: 155,835,541 (GRCm39) T52A probably benign Het
Coro2b A G 9: 62,333,071 (GRCm39) probably benign Het
Ctcf A T 8: 106,390,789 (GRCm39) E132V possibly damaging Het
Cwf19l2 A T 9: 3,456,803 (GRCm39) H712L probably benign Het
Cxcl2 A T 5: 91,052,272 (GRCm39) Q87L possibly damaging Het
Dop1a T C 9: 86,376,486 (GRCm39) V240A probably damaging Het
Etfdh C T 3: 79,521,018 (GRCm39) V294I probably benign Het
Fnip2 C T 3: 79,386,808 (GRCm39) V973I probably benign Het
Fyco1 T C 9: 123,630,348 (GRCm39) T1286A probably benign Het
Gbp10 T A 5: 105,372,324 (GRCm39) E145D possibly damaging Het
Gsdme A T 6: 50,206,428 (GRCm39) N138K possibly damaging Het
Hcn4 A G 9: 58,751,172 (GRCm39) D266G probably benign Het
Henmt1 T C 3: 108,866,001 (GRCm39) V199A probably damaging Het
Hmcn2 A T 2: 31,226,624 (GRCm39) K200* probably null Het
Hmgcr C G 13: 96,787,571 (GRCm39) L852F probably damaging Het
Isl2 A G 9: 55,449,754 (GRCm39) S119G probably benign Het
Krba1 A G 6: 48,388,614 (GRCm39) N538D probably damaging Het
Lcorl A T 5: 45,891,383 (GRCm39) N323K possibly damaging Het
Mfsd2b A G 12: 4,920,578 (GRCm39) S80P probably damaging Het
Ndst4 C T 3: 125,232,385 (GRCm39) T318M probably damaging Het
Nlrp4f T C 13: 65,341,821 (GRCm39) N608S probably benign Het
Nolc1 GCA GCACCA 19: 46,069,797 (GRCm39) probably benign Het
Or6d12 A G 6: 116,493,590 (GRCm39) N284S possibly damaging Het
Or8b4 G A 9: 37,829,937 (GRCm39) probably benign Het
Osbpl2 G A 2: 179,803,353 (GRCm39) R475H probably damaging Het
Ppfibp1 A G 6: 146,898,334 (GRCm39) K97E probably damaging Het
Pramel26 T A 4: 143,537,026 (GRCm39) D435V probably benign Het
Prpsap1 A T 11: 116,363,834 (GRCm39) M263K probably benign Het
Prtg G T 9: 72,749,991 (GRCm39) E132* probably null Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Rttn T C 18: 89,013,777 (GRCm39) V482A probably benign Het
Samsn1 A G 16: 75,706,073 (GRCm39) M1T probably null Het
Scel A G 14: 103,767,440 (GRCm39) N33S probably damaging Het
Sema4g A T 19: 44,989,853 (GRCm39) Y644F probably damaging Het
Slc39a10 G A 1: 46,851,234 (GRCm39) T752M probably damaging Het
Snx27 T C 3: 94,431,551 (GRCm39) D281G probably damaging Het
Spesp1 T A 9: 62,180,318 (GRCm39) I197L probably benign Het
Srsf4 C T 4: 131,627,413 (GRCm39) probably benign Het
Tpgs1 A G 10: 79,505,199 (GRCm39) probably null Het
Trpc2 G A 7: 101,733,711 (GRCm39) S220N probably damaging Het
Ttk C A 9: 83,736,890 (GRCm39) P450T possibly damaging Het
Ttn T G 2: 76,740,165 (GRCm39) Q3458P probably benign Het
Ube2z A G 11: 95,951,893 (GRCm39) F152L probably damaging Het
Utp20 C T 10: 88,598,668 (GRCm39) V103I probably benign Het
Zfa-ps T A 10: 52,420,636 (GRCm39) noncoding transcript Het
Zfp267 T G 3: 36,218,989 (GRCm39) H337Q possibly damaging Het
Other mutations in Ifi203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00565:Ifi203 APN 1 173,765,306 (GRCm39) critical splice donor site probably null
IGL02598:Ifi203 APN 1 173,762,568 (GRCm39) splice site probably benign
IGL03172:Ifi203 APN 1 173,764,158 (GRCm39) missense possibly damaging 0.94
IGL03334:Ifi203 APN 1 173,765,401 (GRCm39) nonsense probably null
FR4304:Ifi203 UTSW 1 173,755,894 (GRCm39) intron probably benign
R0593:Ifi203 UTSW 1 173,756,215 (GRCm39) intron probably benign
R0827:Ifi203 UTSW 1 173,756,029 (GRCm39) intron probably benign
R1163:Ifi203 UTSW 1 173,751,703 (GRCm39) missense probably damaging 0.98
R1769:Ifi203 UTSW 1 173,756,326 (GRCm39) nonsense probably null
R3415:Ifi203 UTSW 1 173,756,326 (GRCm39) nonsense probably null
R3737:Ifi203 UTSW 1 173,757,040 (GRCm39) intron probably benign
R3738:Ifi203 UTSW 1 173,757,040 (GRCm39) intron probably benign
R3739:Ifi203 UTSW 1 173,757,040 (GRCm39) intron probably benign
R3791:Ifi203 UTSW 1 173,762,646 (GRCm39) missense possibly damaging 0.83
R3847:Ifi203 UTSW 1 173,761,362 (GRCm39) missense possibly damaging 0.84
R4156:Ifi203 UTSW 1 173,764,106 (GRCm39) missense probably damaging 0.98
R4164:Ifi203 UTSW 1 173,756,029 (GRCm39) intron probably benign
R4171:Ifi203 UTSW 1 173,761,341 (GRCm39) splice site probably benign
R4200:Ifi203 UTSW 1 173,751,681 (GRCm39) missense probably damaging 0.99
R4233:Ifi203 UTSW 1 173,764,099 (GRCm39) missense possibly damaging 0.92
R4845:Ifi203 UTSW 1 173,754,595 (GRCm39) missense probably benign 0.00
R4880:Ifi203 UTSW 1 173,756,716 (GRCm39) intron probably benign
R5071:Ifi203 UTSW 1 173,762,676 (GRCm39) missense possibly damaging 0.92
R5108:Ifi203 UTSW 1 173,751,580 (GRCm39) missense probably damaging 1.00
R5284:Ifi203 UTSW 1 173,756,274 (GRCm39) intron probably benign
R5335:Ifi203 UTSW 1 173,754,485 (GRCm39) missense possibly damaging 0.71
R6198:Ifi203 UTSW 1 173,751,648 (GRCm39) missense probably damaging 0.97
R6236:Ifi203 UTSW 1 173,761,479 (GRCm39) missense probably benign 0.33
R6397:Ifi203 UTSW 1 173,754,770 (GRCm39) missense probably benign 0.33
R6929:Ifi203 UTSW 1 173,756,340 (GRCm39) intron probably benign
R7025:Ifi203 UTSW 1 173,755,951 (GRCm39) intron probably benign
R7149:Ifi203 UTSW 1 173,756,494 (GRCm39) missense unknown
R7320:Ifi203 UTSW 1 173,756,733 (GRCm39) missense unknown
R7631:Ifi203 UTSW 1 173,754,688 (GRCm39) missense unknown
R7913:Ifi203 UTSW 1 173,754,523 (GRCm39) missense probably damaging 1.00
R8183:Ifi203 UTSW 1 173,756,266 (GRCm39) missense unknown
R8297:Ifi203 UTSW 1 173,765,496 (GRCm39) missense probably damaging 1.00
R8537:Ifi203 UTSW 1 173,756,472 (GRCm39) intron probably benign
R8919:Ifi203 UTSW 1 173,756,494 (GRCm39) missense unknown
R8936:Ifi203 UTSW 1 173,756,857 (GRCm39) intron probably benign
R9081:Ifi203 UTSW 1 173,757,048 (GRCm39) missense unknown
R9223:Ifi203 UTSW 1 173,765,437 (GRCm39) missense probably benign 0.42
R9255:Ifi203 UTSW 1 173,756,787 (GRCm39) missense unknown
R9351:Ifi203 UTSW 1 173,750,133 (GRCm39) missense probably benign 0.33
R9397:Ifi203 UTSW 1 173,765,547 (GRCm39) missense probably damaging 0.99
R9506:Ifi203 UTSW 1 173,751,565 (GRCm39) missense possibly damaging 0.93
R9586:Ifi203 UTSW 1 173,754,623 (GRCm39) nonsense probably null
R9598:Ifi203 UTSW 1 173,751,522 (GRCm39) missense probably damaging 1.00
Z1088:Ifi203 UTSW 1 173,756,147 (GRCm39) intron probably benign
Predicted Primers PCR Primer
(F):5'- AGACACTGGAAGATTGTGGC -3'
(R):5'- CTAAGTGGTAGCCTAAGTGTGG -3'

Sequencing Primer
(F):5'- TGATGTTGGAGAGATTGGAGACATC -3'
(R):5'- CTGACAGGATAAAAGTCCTC -3'
Posted On 2015-04-30