Incidental Mutation 'R4049:Or4a78'
ID 314016
Institutional Source Beutler Lab
Gene Symbol Or4a78
Ensembl Gene ENSMUSG00000111567
Gene Name olfactory receptor family 4 subfamily A member 78
Synonyms Olfr1251, GA_x6K02T2Q125-51109312-51108356, MOR231-15P, MOR231-24_p
MMRRC Submission 041616-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.272) question?
Stock # R4049 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89497272-89498228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89498006 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 75 (I75V)
Ref Sequence ENSEMBL: ENSMUSP00000150028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214304] [ENSMUST00000214639] [ENSMUST00000214750]
AlphaFold Q7TQZ3
Predicted Effect probably benign
Transcript: ENSMUST00000099767
AA Change: I75V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000097355
Gene: ENSMUSG00000075077
AA Change: I75V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.1e-45 PFAM
Pfam:7tm_1 39 285 2.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188085
AA Change: I75V

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000140591
Gene: ENSMUSG00000100323
AA Change: I75V

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.4e-29 PFAM
Pfam:7tm_4 137 278 2e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214304
AA Change: I75V

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000214639
AA Change: I75V

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000214750
AA Change: I75V

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,832,404 (GRCm39) E1190V probably damaging Het
Arhgef10 A G 8: 15,029,998 (GRCm39) T928A probably benign Het
Arhgef10l T A 4: 140,242,762 (GRCm39) I836F probably benign Het
Blm T A 7: 80,152,610 (GRCm39) T446S probably benign Het
Ccdc63 T A 5: 122,260,813 (GRCm39) Q237L probably damaging Het
Ccn5 A G 2: 163,670,904 (GRCm39) D137G probably damaging Het
Cep57l1 G T 10: 41,605,356 (GRCm39) R130S probably damaging Het
Clstn2 T G 9: 97,339,613 (GRCm39) E786A possibly damaging Het
Col16a1 C T 4: 129,962,545 (GRCm39) P540L probably damaging Het
Csf2 A G 11: 54,140,159 (GRCm39) F61L probably damaging Het
Ctr9 C T 7: 110,654,750 (GRCm39) R1094C unknown Het
Cyp3a41a A G 5: 145,650,350 (GRCm39) C98R probably damaging Het
Dthd1 T A 5: 62,984,508 (GRCm39) C404* probably null Het
Egfem1 A C 3: 29,740,880 (GRCm39) H518P probably benign Het
Elf3 T C 1: 135,182,015 (GRCm39) S369G probably benign Het
Eml6 C T 11: 29,788,577 (GRCm39) V503M probably damaging Het
Enthd1 T C 15: 80,444,240 (GRCm39) D105G probably damaging Het
Eral1 A G 11: 77,966,428 (GRCm39) L250P probably damaging Het
Gdf15 A T 8: 71,082,605 (GRCm39) M167K probably benign Het
Ggps1 T C 13: 14,228,284 (GRCm39) K300E probably benign Het
Gm8074 G A 9: 78,229,618 (GRCm39) noncoding transcript Het
Herc3 A G 6: 58,853,822 (GRCm39) I623V probably damaging Het
Mad1l1 A G 5: 140,118,571 (GRCm39) S457P probably damaging Het
Map1lc3a G T 2: 155,119,462 (GRCm39) V91F possibly damaging Het
Map4k3 A G 17: 80,913,394 (GRCm39) V617A probably benign Het
Mov10l1 T A 15: 88,879,235 (GRCm39) probably benign Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Ncor1 G T 11: 62,220,494 (GRCm39) probably null Het
Nfe2 C T 15: 103,159,364 (GRCm39) E36K possibly damaging Het
Oprm1 G A 10: 6,779,087 (GRCm39) V95I probably benign Het
Or4c107 A G 2: 88,789,617 (GRCm39) K269R probably benign Het
Or52d3 T C 7: 104,229,575 (GRCm39) F241L probably benign Het
Or5d46 T C 2: 88,174,144 (GRCm39) probably null Het
Pcdha9 T A 18: 37,130,995 (GRCm39) H21Q probably benign Het
Pcolce2 A T 9: 95,520,808 (GRCm39) I62F probably damaging Het
Pfpl T A 19: 12,407,053 (GRCm39) C435S probably damaging Het
Pkhd1l1 G A 15: 44,361,953 (GRCm39) C542Y probably damaging Het
Plekha5 T C 6: 140,529,597 (GRCm39) S75P probably damaging Het
Pphln1 C A 15: 93,362,987 (GRCm39) A202E probably damaging Het
Ppp1r1a A G 15: 103,440,881 (GRCm39) L92P probably damaging Het
Prokr2 T C 2: 132,223,414 (GRCm39) T43A probably benign Het
Rai14 T C 15: 10,592,298 (GRCm39) N199S probably benign Het
Rasgrp2 T C 19: 6,454,757 (GRCm39) L199P probably damaging Het
Rnf213 A C 11: 119,373,274 (GRCm39) M4939L possibly damaging Het
Slc23a2 C T 2: 131,902,603 (GRCm39) R533Q probably benign Het
Slc7a7 T C 14: 54,610,548 (GRCm39) probably null Het
Snrpd2 T A 7: 18,885,232 (GRCm39) V31E probably damaging Het
Spire1 G T 18: 67,662,101 (GRCm39) probably null Het
Srsf4 T C 4: 131,627,854 (GRCm39) probably benign Het
Tcf20 A G 15: 82,737,630 (GRCm39) S1274P probably damaging Het
Tcof1 C A 18: 60,965,975 (GRCm39) A376S possibly damaging Het
Thsd1 T A 8: 22,733,180 (GRCm39) Y76N possibly damaging Het
Timm44 A G 8: 4,310,561 (GRCm39) V397A probably benign Het
Tmc6 G A 11: 117,669,087 (GRCm39) T89I possibly damaging Het
Trbv31 C A 6: 41,534,639 (GRCm39) C107F probably damaging Het
Trim37 T A 11: 87,031,429 (GRCm39) probably null Het
Ttll5 T C 12: 86,059,573 (GRCm39) V1226A probably benign Het
Ube3b T C 5: 114,550,931 (GRCm39) V865A probably benign Het
Vmn2r86 A T 10: 130,282,966 (GRCm39) M550K probably damaging Het
Vps54 C A 11: 21,250,183 (GRCm39) T373N probably benign Het
Wdr64 T G 1: 175,633,422 (GRCm39) I891S probably benign Het
Zfhx4 C T 3: 5,463,919 (GRCm39) S1384L probably damaging Het
Zfp703 A G 8: 27,469,113 (GRCm39) E259G possibly damaging Het
Zfp933 T C 4: 147,910,969 (GRCm39) H209R probably damaging Het
Zfp980 A G 4: 145,429,170 (GRCm39) H633R probably damaging Het
Other mutations in Or4a78
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01817:Or4a78 APN 2 89,497,348 (GRCm39) missense probably benign 0.00
IGL01941:Or4a78 APN 2 89,497,812 (GRCm39) nonsense probably null 0.00
IGL01988:Or4a78 APN 2 89,497,424 (GRCm39) missense probably benign 0.07
IGL02388:Or4a78 APN 2 89,497,316 (GRCm39) missense probably benign 0.00
IGL03169:Or4a78 APN 2 89,497,831 (GRCm39) missense possibly damaging 0.86
R0008:Or4a78 UTSW 2 89,497,428 (GRCm39) missense probably damaging 1.00
R0042:Or4a78 UTSW 2 89,497,798 (GRCm39) missense probably benign 0.01
R0834:Or4a78 UTSW 2 89,497,423 (GRCm39) missense probably benign 0.24
R1102:Or4a78 UTSW 2 89,497,814 (GRCm39) missense probably damaging 0.98
R2213:Or4a78 UTSW 2 89,497,891 (GRCm39) missense probably damaging 1.00
R2219:Or4a78 UTSW 2 89,498,211 (GRCm39) missense possibly damaging 0.73
R3023:Or4a78 UTSW 2 89,497,990 (GRCm39) missense possibly damaging 0.86
R3105:Or4a78 UTSW 2 89,497,302 (GRCm39) missense probably benign 0.01
R3433:Or4a78 UTSW 2 89,497,577 (GRCm39) missense probably benign 0.01
R3508:Or4a78 UTSW 2 89,497,816 (GRCm39) missense probably benign 0.14
R3758:Or4a78 UTSW 2 89,497,916 (GRCm39) missense probably benign 0.14
R3909:Or4a78 UTSW 2 89,497,357 (GRCm39) missense probably damaging 0.98
R4457:Or4a78 UTSW 2 89,497,427 (GRCm39) missense probably benign 0.24
R5613:Or4a78 UTSW 2 89,497,388 (GRCm39) missense probably damaging 1.00
R5748:Or4a78 UTSW 2 89,498,146 (GRCm39) missense possibly damaging 0.67
R6226:Or4a78 UTSW 2 89,497,333 (GRCm39) missense probably damaging 1.00
R6950:Or4a78 UTSW 2 89,497,895 (GRCm39) missense probably benign 0.07
R9129:Or4a78 UTSW 2 89,497,930 (GRCm39) missense probably damaging 1.00
R9792:Or4a78 UTSW 2 89,497,811 (GRCm39) missense probably benign 0.00
R9793:Or4a78 UTSW 2 89,497,811 (GRCm39) missense probably benign 0.00
R9795:Or4a78 UTSW 2 89,497,811 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GAGGATACATACCCTTCGATTCATG -3'
(R):5'- CAGAATTTGTCCTGCTGGGC -3'

Sequencing Primer
(F):5'- CATGATGATCAAATAATGCAGTGGC -3'
(R):5'- TGGGCTTCACTCAGGATCCTG -3'
Posted On 2015-04-30