Incidental Mutation 'R4052:Or52n3'
ID 314202
Institutional Source Beutler Lab
Gene Symbol Or52n3
Ensembl Gene ENSMUSG00000073917
Gene Name olfactory receptor family 52 subfamily N member 3
Synonyms MOR34-7, Olfr665, GA_x6K02T2PBJ9-7509539-7510489
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R4052 ()
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 104529916-104530866 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 104530810 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 299 (T299A)
Ref Sequence ENSEMBL: ENSMUSP00000150229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098165] [ENSMUST00000215761] [ENSMUST00000216257] [ENSMUST00000216971]
AlphaFold Q8VG79
Predicted Effect probably damaging
Transcript: ENSMUST00000098165
AA Change: T299A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000095768
Gene: ENSMUSG00000073917
AA Change: T299A

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 6.4e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 310 1e-5 PFAM
Pfam:7tm_1 43 295 1.4e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215761
AA Change: T299A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216257
AA Change: T299A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216971
AA Change: T299A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik T G 13: 119,624,738 (GRCm39) probably benign Het
Abca8b G A 11: 109,872,551 (GRCm39) Q17* probably null Het
Abcc6 A C 7: 45,635,987 (GRCm39) L1020R probably damaging Het
Ace2 A G X: 162,952,581 (GRCm39) I110V probably benign Het
Adam29 T C 8: 56,325,317 (GRCm39) Y379C probably damaging Het
Apol10a A T 15: 77,373,185 (GRCm39) I274L probably benign Het
BC005537 T A 13: 24,993,881 (GRCm39) F119I possibly damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Cts3 T A 13: 61,716,535 (GRCm39) I34L probably benign Het
Cyp4a30b A G 4: 115,311,539 (GRCm39) D69G probably benign Het
Dclk2 A G 3: 86,738,129 (GRCm39) probably null Het
Dhx30 A G 9: 109,929,889 (GRCm39) V69A possibly damaging Het
Dis3 T G 14: 99,332,752 (GRCm39) I227L probably benign Het
Dock3 A G 9: 106,850,995 (GRCm39) S836P probably damaging Het
Efhc2 T C X: 17,096,789 (GRCm39) N186S possibly damaging Het
Erap1 A G 13: 74,823,459 (GRCm39) N831S probably benign Het
Gimap3 T A 6: 48,743,447 (GRCm39) T3S possibly damaging Het
Gpr82 C T X: 13,531,898 (GRCm39) P149S probably damaging Het
H3f3a C T 1: 180,630,703 (GRCm39) R117H probably benign Het
Hcn2 A C 10: 79,569,521 (GRCm39) probably null Het
Helz2 A G 2: 180,882,268 (GRCm39) L175P probably damaging Het
Il36b T C 2: 24,049,844 (GRCm39) F152L probably damaging Het
Ino80b G C 6: 83,099,314 (GRCm39) P178R probably damaging Het
Ldlrad3 C T 2: 101,783,507 (GRCm39) D240N probably damaging Het
Lef1 A G 3: 130,988,338 (GRCm39) N236D probably damaging Het
Macf1 A G 4: 123,365,810 (GRCm39) S1419P probably benign Het
Me2 T C 18: 73,924,156 (GRCm39) K352R probably benign Het
Ncapd3 T A 9: 27,000,679 (GRCm39) probably null Het
P2rx7 T C 5: 122,804,340 (GRCm39) F293S probably damaging Het
Pabpc1l T C 2: 163,885,533 (GRCm39) W429R probably benign Het
Parp14 T C 16: 35,678,771 (GRCm39) E399G probably benign Het
Pde6h A G 6: 136,936,266 (GRCm39) D3G unknown Het
Pfkfb1 A T X: 149,405,184 (GRCm39) D208V possibly damaging Het
Rasgrp3 T C 17: 75,803,963 (GRCm39) F89L probably damaging Het
Rif1 A T 2: 51,988,483 (GRCm39) K741* probably null Het
Rnase4 A G 14: 51,342,462 (GRCm39) K62R probably benign Het
Rnf207 C A 4: 152,395,894 (GRCm39) Q533H probably benign Het
Slc24a2 A G 4: 87,145,442 (GRCm39) V204A probably damaging Het
Spry2 A T 14: 106,130,635 (GRCm39) C184S probably damaging Het
Sulf2 T C 2: 165,936,510 (GRCm39) Y152C probably damaging Het
Thrap3 G A 4: 126,070,012 (GRCm39) A625V probably damaging Het
Tmem39a T A 16: 38,406,650 (GRCm39) V329D probably damaging Het
Trav7-3 A G 14: 53,681,203 (GRCm39) T82A probably benign Het
Trim30b T A 7: 104,006,685 (GRCm39) Q57L possibly damaging Het
Uggt1 A G 1: 36,203,570 (GRCm39) V1020A probably damaging Het
Zfp941 T G 7: 140,392,340 (GRCm39) K340Q possibly damaging Het
Other mutations in Or52n3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Or52n3 APN 7 104,530,724 (GRCm39) missense probably benign 0.01
IGL01408:Or52n3 APN 7 104,530,037 (GRCm39) missense probably benign 0.02
IGL02022:Or52n3 APN 7 104,530,141 (GRCm39) missense probably damaging 1.00
R0349:Or52n3 UTSW 7 104,530,199 (GRCm39) missense possibly damaging 0.48
R0585:Or52n3 UTSW 7 104,530,706 (GRCm39) missense probably damaging 1.00
R1518:Or52n3 UTSW 7 104,530,515 (GRCm39) nonsense probably null
R1659:Or52n3 UTSW 7 104,530,387 (GRCm39) missense probably benign 0.00
R1727:Or52n3 UTSW 7 104,530,721 (GRCm39) missense probably benign 0.11
R1762:Or52n3 UTSW 7 104,530,447 (GRCm39) missense probably damaging 0.99
R4208:Or52n3 UTSW 7 104,530,810 (GRCm39) missense probably damaging 0.99
R5486:Or52n3 UTSW 7 104,530,168 (GRCm39) missense probably benign 0.02
R5513:Or52n3 UTSW 7 104,530,706 (GRCm39) missense probably damaging 1.00
R6148:Or52n3 UTSW 7 104,530,289 (GRCm39) missense possibly damaging 0.84
R6593:Or52n3 UTSW 7 104,530,640 (GRCm39) missense probably damaging 1.00
R7143:Or52n3 UTSW 7 104,530,393 (GRCm39) missense probably damaging 1.00
R7189:Or52n3 UTSW 7 104,530,348 (GRCm39) nonsense probably null
R7413:Or52n3 UTSW 7 104,530,057 (GRCm39) missense probably benign 0.07
R8690:Or52n3 UTSW 7 104,530,762 (GRCm39) missense probably damaging 1.00
R8819:Or52n3 UTSW 7 104,530,862 (GRCm39) missense possibly damaging 0.90
R8820:Or52n3 UTSW 7 104,530,862 (GRCm39) missense possibly damaging 0.90
R9430:Or52n3 UTSW 7 104,530,204 (GRCm39) missense possibly damaging 0.92
R9464:Or52n3 UTSW 7 104,530,050 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCCTTCAGTACCTGTACATCAC -3'
(R):5'- GTTCCATGAGCTCCAAGACAG -3'

Sequencing Primer
(F):5'- GTACCTGTACATCACACATATGTGC -3'
(R):5'- CAAGACAGCTATATTAGACTCATGC -3'
Posted On 2015-04-30