Incidental Mutation 'R4056:Vmn1r13'
ID314240
Institutional Source Beutler Lab
Gene Symbol Vmn1r13
Ensembl Gene ENSMUSG00000064259
Gene Namevomeronasal 1 receptor 13
SynonymsV1rc5
MMRRC Submission 041617-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #R4056 (G1)
Quality Score225
Status Validated
Chromosome6
Chromosomal Location57203290-57214799 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 57209985 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Tyrosine at position 43 (C43Y)
Ref Sequence ENSEMBL: ENSMUSP00000154429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078885] [ENSMUST00000226892] [ENSMUST00000227298] [ENSMUST00000227421]
Predicted Effect probably benign
Transcript: ENSMUST00000078885
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000077924
Gene: ENSMUSG00000064259
AA Change: C43Y

DomainStartEndE-ValueType
Pfam:V1R 28 294 3.3e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226892
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227298
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227421
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Meta Mutation Damage Score 0.128 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730455P16Rik T A 11: 80,375,503 probably benign Het
Abcf1 A G 17: 35,959,915 I510T possibly damaging Het
Adamts18 T A 8: 113,737,580 K749* probably null Het
Alms1 A G 6: 85,587,803 E53G unknown Het
Bmper A G 9: 23,399,629 H453R probably benign Het
Btg1 T A 10: 96,618,354 M1K probably null Het
Cntfr A G 4: 41,658,900 I277T probably damaging Het
Col6a4 C A 9: 106,026,466 R1642I probably damaging Het
Ctnna3 T C 10: 65,002,568 I808T probably damaging Het
Cyp1a1 T A 9: 57,700,149 V20D probably benign Het
Dnah17 T C 11: 118,070,538 T2554A probably benign Het
Fcgbp A T 7: 28,104,116 Q1715L probably benign Het
Gabarapl1 T C 6: 129,538,630 F77S probably damaging Het
Gm1966 G T 7: 106,604,009 D9E possibly damaging Het
Hpse2 T C 19: 43,294,275 K180E probably damaging Het
Hs3st2 T A 7: 121,500,702 L257Q probably damaging Het
Ighv1-18 T C 12: 114,682,667 T106A probably benign Het
Ints2 A C 11: 86,242,952 L424R probably damaging Het
Iqgap2 A G 13: 95,750,033 V114A probably damaging Het
Kalrn A T 16: 34,314,209 I401N probably damaging Het
Maats1 A G 16: 38,298,214 V741A probably benign Het
Mast2 T A 4: 116,337,501 probably benign Het
Myo18a A G 11: 77,812,013 E5G possibly damaging Het
Nav3 A T 10: 109,880,533 probably null Het
Net1 G A 13: 3,884,949 T359I probably damaging Het
Pcsk9 T A 4: 106,444,702 H616L probably benign Het
Plekha5 G T 6: 140,589,232 V597L possibly damaging Het
Plekhg3 T A 12: 76,565,247 I374N probably damaging Het
Pros1 A T 16: 62,900,645 R188* probably null Het
Rhbg C T 3: 88,243,448 V434I probably damaging Het
Rims1 A G 1: 22,292,939 probably benign Het
Rxfp2 T C 5: 150,051,633 probably null Het
Sbf2 T C 7: 110,441,466 I385V probably damaging Het
Slc22a23 A C 13: 34,299,004 Y181* probably null Het
Spata31 T A 13: 64,921,655 V539E probably benign Het
Trpv5 G A 6: 41,659,705 R436C probably damaging Het
Wif1 G A 10: 121,082,194 V156I probably benign Het
Zfyve16 T C 13: 92,504,549 N1229S probably damaging Het
Other mutations in Vmn1r13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Vmn1r13 APN 6 57210113 missense probably benign 0.10
IGL01511:Vmn1r13 APN 6 57210329 missense probably benign 0.00
IGL02412:Vmn1r13 APN 6 57210489 missense possibly damaging 0.46
IGL02455:Vmn1r13 APN 6 57210472 missense probably damaging 1.00
IGL03046:Vmn1r13 APN 6 57210732 missense probably benign
R0285:Vmn1r13 UTSW 6 57209994 missense probably benign 0.06
R0304:Vmn1r13 UTSW 6 57210626 missense probably benign 0.01
R0385:Vmn1r13 UTSW 6 57210705 missense probably benign 0.06
R0402:Vmn1r13 UTSW 6 57210098 missense possibly damaging 0.96
R0544:Vmn1r13 UTSW 6 57210263 missense probably benign
R0960:Vmn1r13 UTSW 6 57210011 missense probably benign 0.06
R1297:Vmn1r13 UTSW 6 57210407 missense probably damaging 0.99
R5108:Vmn1r13 UTSW 6 57209916 missense probably benign 0.33
R6388:Vmn1r13 UTSW 6 57209918 missense probably benign 0.01
R7136:Vmn1r13 UTSW 6 57210254 missense possibly damaging 0.93
X0066:Vmn1r13 UTSW 6 57210597 missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GAATCACAAGTTTCATGCGTTG -3'
(R):5'- TTGTGACAGCCTGGATCAC -3'

Sequencing Primer
(F):5'- TTTCAGGAATAAGAATATGATTCCCC -3'
(R):5'- AGCCTGGATCACACTCAGGAG -3'
Posted On2015-04-30