Mutagenetix > Incidental Mutation

Incidental Mutation 'R4056:Vmn1r13'

314240

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r13

Ensembl Gene

ENSMUSG00000064259

Gene Name

vomeronasal 1 receptor 13

Synonyms

V1rc5

MMRRC Submission

041617-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R4056 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57186843-57187745 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 57186970 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 43 (C43Y)

Ref Sequence

ENSEMBL: ENSMUSP00000154429 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078885] [ENSMUST00000226892] [ENSMUST00000227298] [ENSMUST00000227421]

AlphaFold

G5E8I3

Predicted Effect

probably benign
Transcript: ENSMUST00000078885
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000077924
Gene: ENSMUSG00000064259
AA Change: C43Y

Domain	Start	End	E-Value	Type
Pfam:V1R	28	294	3.3e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226892
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

Predicted Effect

probably benign
Transcript: ENSMUST00000227298
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

Predicted Effect

probably benign
Transcript: ENSMUST00000227421
AA Change: C43Y

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.6%

Validation Efficiency

100% (39/39)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730455P16Rik	T	A	11: 80,266,329 (GRCm39)		probably benign	Het
Abcf1	A	G	17: 36,270,807 (GRCm39)	I510T	possibly damaging	Het
Adamts18	T	A	8: 114,464,212 (GRCm39)	K749*	probably null	Het
Alms1	A	G	6: 85,564,785 (GRCm39)	E53G	unknown	Het
Bmper	A	G	9: 23,310,925 (GRCm39)	H453R	probably benign	Het
Btg1	T	A	10: 96,454,216 (GRCm39)	M1K	probably null	Het
Cfap91	A	G	16: 38,118,576 (GRCm39)	V741A	probably benign	Het
Cntfr	A	G	4: 41,658,900 (GRCm39)	I277T	probably damaging	Het
Col6a4	C	A	9: 105,903,665 (GRCm39)	R1642I	probably damaging	Het
Ctnna3	T	C	10: 64,838,347 (GRCm39)	I808T	probably damaging	Het
Cyp1a1	T	A	9: 57,607,432 (GRCm39)	V20D	probably benign	Het
Dnah17	T	C	11: 117,961,364 (GRCm39)	T2554A	probably benign	Het
Fcgbp	A	T	7: 27,803,541 (GRCm39)	Q1715L	probably benign	Het
Gabarapl1	T	C	6: 129,515,593 (GRCm39)	F77S	probably damaging	Het
Gvin3	G	T	7: 106,203,216 (GRCm39)	D9E	possibly damaging	Het
Hpse2	T	C	19: 43,282,714 (GRCm39)	K180E	probably damaging	Het
Hs3st2	T	A	7: 121,099,925 (GRCm39)	L257Q	probably damaging	Het
Ighv1-18	T	C	12: 114,646,287 (GRCm39)	T106A	probably benign	Het
Ints2	A	C	11: 86,133,778 (GRCm39)	L424R	probably damaging	Het
Iqgap2	A	G	13: 95,886,541 (GRCm39)	V114A	probably damaging	Het
Kalrn	A	T	16: 34,134,579 (GRCm39)	I401N	probably damaging	Het
Mast2	T	A	4: 116,194,698 (GRCm39)		probably benign	Het
Myo18a	A	G	11: 77,702,839 (GRCm39)	E5G	possibly damaging	Het
Nav3	A	T	10: 109,716,394 (GRCm39)		probably null	Het
Net1	G	A	13: 3,934,949 (GRCm39)	T359I	probably damaging	Het
Pcsk9	T	A	4: 106,301,899 (GRCm39)	H616L	probably benign	Het
Plekha5	G	T	6: 140,534,958 (GRCm39)	V597L	possibly damaging	Het
Plekhg3	T	A	12: 76,612,021 (GRCm39)	I374N	probably damaging	Het
Pros1	A	T	16: 62,721,008 (GRCm39)	R188*	probably null	Het
Rhbg	C	T	3: 88,150,755 (GRCm39)	V434I	probably damaging	Het
Rims1	A	G	1: 22,363,163 (GRCm39)		probably benign	Het
Rxfp2	T	C	5: 149,975,098 (GRCm39)		probably null	Het
Sbf2	T	C	7: 110,040,673 (GRCm39)	I385V	probably damaging	Het
Slc22a23	A	C	13: 34,482,987 (GRCm39)	Y181*	probably null	Het
Spata31	T	A	13: 65,069,469 (GRCm39)	V539E	probably benign	Het
Trpv5	G	A	6: 41,636,639 (GRCm39)	R436C	probably damaging	Het
Wif1	G	A	10: 120,918,099 (GRCm39)	V156I	probably benign	Het
Zfyve16	T	C	13: 92,641,057 (GRCm39)	N1229S	probably damaging	Het

Other mutations in Vmn1r13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00870:Vmn1r13	APN	6	57,187,098 (GRCm39)	missense	probably benign	0.10
IGL01511:Vmn1r13	APN	6	57,187,314 (GRCm39)	missense	probably benign	0.00
IGL02412:Vmn1r13	APN	6	57,187,474 (GRCm39)	missense	possibly damaging	0.46
IGL02455:Vmn1r13	APN	6	57,187,457 (GRCm39)	missense	probably damaging	1.00
IGL03046:Vmn1r13	APN	6	57,187,717 (GRCm39)	missense	probably benign
R0285:Vmn1r13	UTSW	6	57,186,979 (GRCm39)	missense	probably benign	0.06
R0304:Vmn1r13	UTSW	6	57,187,611 (GRCm39)	missense	probably benign	0.01
R0385:Vmn1r13	UTSW	6	57,187,690 (GRCm39)	missense	probably benign	0.06
R0402:Vmn1r13	UTSW	6	57,187,083 (GRCm39)	missense	possibly damaging	0.96
R0544:Vmn1r13	UTSW	6	57,187,248 (GRCm39)	missense	probably benign
R0960:Vmn1r13	UTSW	6	57,186,996 (GRCm39)	missense	probably benign	0.06
R1297:Vmn1r13	UTSW	6	57,187,392 (GRCm39)	missense	probably damaging	0.99
R5108:Vmn1r13	UTSW	6	57,186,901 (GRCm39)	missense	probably benign	0.33
R6388:Vmn1r13	UTSW	6	57,186,903 (GRCm39)	missense	probably benign	0.01
R7136:Vmn1r13	UTSW	6	57,187,239 (GRCm39)	missense	possibly damaging	0.93
R7204:Vmn1r13	UTSW	6	57,187,141 (GRCm39)	missense	probably benign	0.13
R7239:Vmn1r13	UTSW	6	57,187,611 (GRCm39)	missense	probably benign	0.01
R7303:Vmn1r13	UTSW	6	57,187,587 (GRCm39)	missense	probably damaging	1.00
R7997:Vmn1r13	UTSW	6	57,187,329 (GRCm39)	missense	possibly damaging	0.81
R8759:Vmn1r13	UTSW	6	57,187,524 (GRCm39)	missense	probably damaging	1.00
R9623:Vmn1r13	UTSW	6	57,187,549 (GRCm39)	missense	probably benign	0.00
X0066:Vmn1r13	UTSW	6	57,187,582 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- GAATCACAAGTTTCATGCGTTG -3'
(R):5'- TTGTGACAGCCTGGATCAC -3'

Sequencing Primer
(F):5'- TTTCAGGAATAAGAATATGATTCCCC -3'
(R):5'- AGCCTGGATCACACTCAGGAG -3'

Posted On

2015-04-30