Incidental Mutation 'R4056:Gvin3'
ID 314245
Institutional Source Beutler Lab
Gene Symbol Gvin3
Ensembl Gene ENSMUSG00000073902
Gene Name GTPase, very large interferon inducible, family member 3
Synonyms Gm1966
MMRRC Submission 041617-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R4056 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 106195950-106203242 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 106203216 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 9 (D9E)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000098144
AA Change: D9E

PolyPhen 2 Score 0.590 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000095748
Gene: ENSMUSG00000073902
AA Change: D9E

DomainStartEndE-ValueType
low complexity region 101 116 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184540
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730455P16Rik T A 11: 80,266,329 (GRCm39) probably benign Het
Abcf1 A G 17: 36,270,807 (GRCm39) I510T possibly damaging Het
Adamts18 T A 8: 114,464,212 (GRCm39) K749* probably null Het
Alms1 A G 6: 85,564,785 (GRCm39) E53G unknown Het
Bmper A G 9: 23,310,925 (GRCm39) H453R probably benign Het
Btg1 T A 10: 96,454,216 (GRCm39) M1K probably null Het
Cfap91 A G 16: 38,118,576 (GRCm39) V741A probably benign Het
Cntfr A G 4: 41,658,900 (GRCm39) I277T probably damaging Het
Col6a4 C A 9: 105,903,665 (GRCm39) R1642I probably damaging Het
Ctnna3 T C 10: 64,838,347 (GRCm39) I808T probably damaging Het
Cyp1a1 T A 9: 57,607,432 (GRCm39) V20D probably benign Het
Dnah17 T C 11: 117,961,364 (GRCm39) T2554A probably benign Het
Fcgbp A T 7: 27,803,541 (GRCm39) Q1715L probably benign Het
Gabarapl1 T C 6: 129,515,593 (GRCm39) F77S probably damaging Het
Hpse2 T C 19: 43,282,714 (GRCm39) K180E probably damaging Het
Hs3st2 T A 7: 121,099,925 (GRCm39) L257Q probably damaging Het
Ighv1-18 T C 12: 114,646,287 (GRCm39) T106A probably benign Het
Ints2 A C 11: 86,133,778 (GRCm39) L424R probably damaging Het
Iqgap2 A G 13: 95,886,541 (GRCm39) V114A probably damaging Het
Kalrn A T 16: 34,134,579 (GRCm39) I401N probably damaging Het
Mast2 T A 4: 116,194,698 (GRCm39) probably benign Het
Myo18a A G 11: 77,702,839 (GRCm39) E5G possibly damaging Het
Nav3 A T 10: 109,716,394 (GRCm39) probably null Het
Net1 G A 13: 3,934,949 (GRCm39) T359I probably damaging Het
Pcsk9 T A 4: 106,301,899 (GRCm39) H616L probably benign Het
Plekha5 G T 6: 140,534,958 (GRCm39) V597L possibly damaging Het
Plekhg3 T A 12: 76,612,021 (GRCm39) I374N probably damaging Het
Pros1 A T 16: 62,721,008 (GRCm39) R188* probably null Het
Rhbg C T 3: 88,150,755 (GRCm39) V434I probably damaging Het
Rims1 A G 1: 22,363,163 (GRCm39) probably benign Het
Rxfp2 T C 5: 149,975,098 (GRCm39) probably null Het
Sbf2 T C 7: 110,040,673 (GRCm39) I385V probably damaging Het
Slc22a23 A C 13: 34,482,987 (GRCm39) Y181* probably null Het
Spata31 T A 13: 65,069,469 (GRCm39) V539E probably benign Het
Trpv5 G A 6: 41,636,639 (GRCm39) R436C probably damaging Het
Vmn1r13 G A 6: 57,186,970 (GRCm39) C43Y probably benign Het
Wif1 G A 10: 120,918,099 (GRCm39) V156I probably benign Het
Zfyve16 T C 13: 92,641,057 (GRCm39) N1229S probably damaging Het
Other mutations in Gvin3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01400:Gvin3 APN 7 106,201,242 (GRCm39) missense probably benign 0.10
IGL01410:Gvin3 APN 7 106,202,258 (GRCm39) exon noncoding transcript
IGL01415:Gvin3 APN 7 106,202,258 (GRCm39) exon noncoding transcript
IGL01538:Gvin3 APN 7 106,201,744 (GRCm39) missense probably damaging 0.96
IGL01751:Gvin3 APN 7 106,201,516 (GRCm39) missense possibly damaging 0.80
IGL01916:Gvin3 APN 7 106,201,033 (GRCm39) missense probably benign 0.28
IGL02171:Gvin3 APN 7 106,200,548 (GRCm39) exon noncoding transcript
IGL02550:Gvin3 APN 7 106,200,846 (GRCm39) exon noncoding transcript
H8562:Gvin3 UTSW 7 106,202,356 (GRCm39) missense probably damaging 1.00
R0016:Gvin3 UTSW 7 106,202,453 (GRCm39) missense probably benign 0.00
R0178:Gvin3 UTSW 7 106,201,028 (GRCm39) missense probably damaging 1.00
R0420:Gvin3 UTSW 7 106,203,090 (GRCm39) missense probably damaging 1.00
R0658:Gvin3 UTSW 7 106,202,093 (GRCm39) missense possibly damaging 0.89
R1378:Gvin3 UTSW 7 106,201,373 (GRCm39) missense probably damaging 0.97
R1506:Gvin3 UTSW 7 106,200,788 (GRCm39) missense probably benign 0.08
R1628:Gvin3 UTSW 7 106,202,476 (GRCm39) nonsense probably null
R1834:Gvin3 UTSW 7 106,202,983 (GRCm39) missense possibly damaging 0.79
R1888:Gvin3 UTSW 7 106,196,630 (GRCm39) exon noncoding transcript
R2145:Gvin3 UTSW 7 106,202,215 (GRCm39) missense possibly damaging 0.84
R4067:Gvin3 UTSW 7 106,198,772 (GRCm39) exon noncoding transcript
R4631:Gvin3 UTSW 7 106,198,730 (GRCm39) exon noncoding transcript
R4817:Gvin3 UTSW 7 106,200,437 (GRCm39) exon noncoding transcript
R4900:Gvin3 UTSW 7 106,197,793 (GRCm39) exon noncoding transcript
R4970:Gvin3 UTSW 7 106,199,864 (GRCm39) exon noncoding transcript
R5009:Gvin3 UTSW 7 106,200,767 (GRCm39) exon noncoding transcript
R5050:Gvin3 UTSW 7 106,196,179 (GRCm39) exon noncoding transcript
R5086:Gvin3 UTSW 7 106,197,234 (GRCm39) exon noncoding transcript
R5090:Gvin3 UTSW 7 106,200,109 (GRCm39) exon noncoding transcript
R5168:Gvin3 UTSW 7 106,196,054 (GRCm39) exon noncoding transcript
R5260:Gvin3 UTSW 7 106,198,411 (GRCm39) exon noncoding transcript
R5331:Gvin3 UTSW 7 106,197,958 (GRCm39) exon noncoding transcript
R5389:Gvin3 UTSW 7 106,197,442 (GRCm39) exon noncoding transcript
R5433:Gvin3 UTSW 7 106,199,314 (GRCm39) exon noncoding transcript
R5488:Gvin3 UTSW 7 106,200,797 (GRCm39) exon noncoding transcript
R5489:Gvin3 UTSW 7 106,200,797 (GRCm39) exon noncoding transcript
R5504:Gvin3 UTSW 7 106,201,951 (GRCm39) exon noncoding transcript
R5956:Gvin3 UTSW 7 106,200,677 (GRCm39) exon noncoding transcript
Predicted Primers PCR Primer
(F):5'- CATGCTGTGTCTGGGACTTC -3'
(R):5'- TGTCATGCTGAGAACACCC -3'

Sequencing Primer
(F):5'- CTGTGTCTGGGACTTCAGATTC -3'
(R):5'- GTCATGCTGAGAACACCCACAATG -3'
Posted On 2015-04-30