|Institutional Source||Beutler Lab|
|Gene Name||B cell translocation gene 1, anti-proliferative|
|Is this an essential gene?||Probably non essential (E-score: 0.197)|
|Stock #||R4056 (G1)|
|Chromosomal Location||96617006-96622809 bp(+) (GRCm38)|
|Type of Mutation||start codon destroyed|
|DNA Base Change (assembly)||T to A at 96618354 bp|
|Amino Acid Change||Methionine to Lysine at position 1 (M1K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000151604 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038377] [ENSMUST00000218953]|
|Predicted Effect||probably damaging
AA Change: M76K
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: M76K
|Predicted Effect||probably null
AA Change: M1K
PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|Meta Mutation Damage Score||0.39|
|Coding Region Coverage||
|Validation Efficiency||100% (39/39)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal neurogenesis in the dentate gyrus, decreased proliferation and increased apoptosis in the dentate gyrus and subventricular zone, impaired spatial learning and abnormal contextual conditioning behavior. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Btg1||
(F):5'- TCTCACGACAGCGAATTCGG -3'
(R):5'- TTGAGTGCTACCTCCTGCTG -3'
(F):5'- CGGTCCCGGACATTTGTGAAAG -3'
(R):5'- TGGTGAGGCTTCGTACAGCAC -3'