Incidental Mutation 'R4132:Vmn1r210'
| ID |
314711 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r210
|
| Ensembl Gene |
ENSMUSG00000061296 |
| Gene Name |
vomeronasal 1 receptor 210 |
| Synonyms |
V1rh10 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R4132 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
23011364-23012284 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23011819 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 156
(I156V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153776
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072044]
[ENSMUST00000226180]
[ENSMUST00000226294]
|
| AlphaFold |
Q8R274 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072044
AA Change: I156V
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000071925
Gene: ENSMUSG00000061296
AA Change: I156V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
34 |
297 |
8.6e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226180
AA Change: I156V
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226294
AA Change: I156V
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankmy1 |
T |
C |
1: 92,812,822 (GRCm39) |
M496V |
probably benign |
Het |
| Ankrd29 |
G |
A |
18: 12,387,757 (GRCm39) |
A275V |
possibly damaging |
Het |
| Cmklr1 |
C |
A |
5: 113,752,545 (GRCm39) |
R152L |
probably damaging |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Gm1527 |
A |
T |
3: 28,974,779 (GRCm39) |
I531L |
probably benign |
Het |
| Grm7 |
G |
T |
6: 110,623,309 (GRCm39) |
V161F |
probably damaging |
Het |
| Heca |
A |
G |
10: 17,777,987 (GRCm39) |
S537P |
probably damaging |
Het |
| Icam5 |
T |
C |
9: 20,947,953 (GRCm39) |
I617T |
probably benign |
Het |
| Itgb2l |
A |
G |
16: 96,238,589 (GRCm39) |
L70P |
probably damaging |
Het |
| Kcnh8 |
GAGACCAACGAGCAGCTGATGCTTCAGA |
GAGA |
17: 53,032,934 (GRCm39) |
74 |
probably benign |
Het |
| Klhdc4 |
C |
T |
8: 122,524,804 (GRCm39) |
G375R |
possibly damaging |
Het |
| Myo5c |
G |
A |
9: 75,159,850 (GRCm39) |
V293I |
probably benign |
Het |
| Ncbp1 |
C |
T |
4: 46,169,241 (GRCm39) |
R672* |
probably null |
Het |
| Pcdhga2 |
T |
C |
18: 37,803,107 (GRCm39) |
I317T |
possibly damaging |
Het |
| Safb |
C |
A |
17: 56,907,848 (GRCm39) |
|
probably benign |
Het |
| Tspan5 |
C |
T |
3: 138,602,628 (GRCm39) |
R106* |
probably null |
Het |
| Ubap2l |
A |
G |
3: 89,916,491 (GRCm39) |
Y908H |
probably damaging |
Het |
| Uspl1 |
A |
G |
5: 149,141,159 (GRCm39) |
N372S |
probably damaging |
Het |
| Zbtb8os |
A |
G |
4: 129,229,906 (GRCm39) |
Y24C |
probably damaging |
Het |
|
| Other mutations in Vmn1r210 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00938:Vmn1r210
|
APN |
13 |
23,011,538 (GRCm39) |
nonsense |
probably null |
|
|
IGL01541:Vmn1r210
|
APN |
13 |
23,011,778 (GRCm39) |
missense |
probably benign |
|
|
IGL01610:Vmn1r210
|
APN |
13 |
23,011,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01632:Vmn1r210
|
APN |
13 |
23,011,366 (GRCm39) |
makesense |
probably null |
|
|
IGL03268:Vmn1r210
|
APN |
13 |
23,011,405 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL03340:Vmn1r210
|
APN |
13 |
23,011,644 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0227:Vmn1r210
|
UTSW |
13 |
23,011,561 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0629:Vmn1r210
|
UTSW |
13 |
23,012,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Vmn1r210
|
UTSW |
13 |
23,011,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4125:Vmn1r210
|
UTSW |
13 |
23,011,779 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4773:Vmn1r210
|
UTSW |
13 |
23,011,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5653:Vmn1r210
|
UTSW |
13 |
23,011,378 (GRCm39) |
nonsense |
probably null |
|
|
R6128:Vmn1r210
|
UTSW |
13 |
23,012,277 (GRCm39) |
nonsense |
probably null |
|
|
R6452:Vmn1r210
|
UTSW |
13 |
23,011,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6501:Vmn1r210
|
UTSW |
13 |
23,011,705 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6864:Vmn1r210
|
UTSW |
13 |
23,011,713 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7623:Vmn1r210
|
UTSW |
13 |
23,011,405 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7991:Vmn1r210
|
UTSW |
13 |
23,011,684 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9244:Vmn1r210
|
UTSW |
13 |
23,012,089 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9439:Vmn1r210
|
UTSW |
13 |
23,011,397 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9538:Vmn1r210
|
UTSW |
13 |
23,011,837 (GRCm39) |
nonsense |
probably null |
|
|
R9732:Vmn1r210
|
UTSW |
13 |
23,011,379 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9794:Vmn1r210
|
UTSW |
13 |
23,011,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGACACTTTGAGCAGCTC -3'
(R):5'- AGCAGTCTCCTCACTGTGGTAC -3'
Sequencing Primer
(F):5'- TCTCAGCTCAGGGGGAGTTC -3'
(R):5'- GTGGTACAGGCCATCATTATCAGTC -3'
|
| Posted On |
2015-05-14 |
Incidental Mutation